Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions

Antigen‐specific and cross‐reactive T cells in protection and disease

(2023) Ning Jiang et al.   IMMUNOLOGICAL REVIEWS

TCRmodel2: high-resolution modeling of T cell receptor recognition using deep learning

(2023) Rui Yin et al.   NUCLEIC ACIDS RESEARCH

Cross-reactivity influences changes in human influenza A virus and Epstein Barr virus specific CD8 memory T cell receptor alpha and beta repertoires between young and old

(2023) Fransenio Clark et al.   Frontiers in Immunology

Systems-level conservation of the proximal TCR signaling network of mice and humans

(2022) Philippe Nicolas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation and comparison of adaptive immunity through analyzing the diversities and clonalities of T-cell receptor repertoires in the peripheral blood

(2022) Yue Zhuo et al.   Frontiers in Immunology

High-throughput and single-cell T cell receptor sequencing technologies

(2021) Joy A. Pai et al.   NATURE METHODS

High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires

(2020) Cinque Soto et al.   Cell Reports

T-cell repertoire analysis and metrics of diversity and clonality

(2020) Johanna Chiffelle et al.   CURRENT OPINION IN BIOTECHNOLOGY

Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases

(2020) Pierre Barennes et al.   NATURE BIOTECHNOLOGY

T-cell receptor repertoire of cytomegalovirus-specific cytotoxic T-cells after allogeneic stem cell transplantation

(2020) Takashi Toya et al.   Scientific Reports

Genesis of the αβ T-cell receptor

(2019) Thomas Dupic et al.   PLoS Computational Biology

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors

(2019) Nathaniel D. Chu et al.   BMC IMMUNOLOGY

Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity

(2019) Jason A. Carter et al.   Frontiers in Immunology

Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins

(2019) Hidetaka Tanno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strong homeostatic TCR signals induce formation of self‐tolerant virtual memory CD8 T cells

(2018) Ales Drobek et al.   EMBO JOURNAL

Immune Repertoire Sequencing Using Molecular Identifiers Enables Accurate Clonality Discovery and Clone Size Quantification

(2018) Ke-Yue Ma et al.   Frontiers in Immunology

Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

(2018) Sneha Sant et al.   Frontiers in Immunology

Single Cell T Cell Receptor Sequencing: Techniques and Future Challenges

(2018) Marco De Simone et al.   Frontiers in Immunology

Some deterministic and stochastic mathematical models of naïve T-cell homeostasis

(2018) Grant Lythe et al.   IMMUNOLOGICAL REVIEWS

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

(2018) William S DeWitt et al.   eLife

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

(2018) Evgeny S. Egorov et al.   Frontiers in Immunology

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

(2018) Paul Lindau et al.   JOURNAL OF IMMUNOLOGY

Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors

(2017) Kengo Yoshida et al.   EXPERIMENTAL GERONTOLOGY

Quantifiable predictive features define epitope-specific T cell receptor repertoires

(2017) Pradyot Dash et al.   NATURE

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

Identifying specificity groups in the T cell receptor repertoire

(2017) Jacob Glanville et al.   NATURE

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope

(2017) InYoung Song et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lymphocyte generation and population homeostasis throughout life

(2017) Rolando E. Yanes et al.   SEMINARS IN HEMATOLOGY

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope

(2017) InYoung Song et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8 + TCR Repertoires to Immunodominant Viral Antigens

(2017) Guobing Chen et al.   Cell Reports

Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8+T cell receptor alpha repertoire following allogeneic transplantation

(2016) C. S. Link et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

(2016) Olga V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination

(2016) Qian Qi et al.   Science Translational Medicine

Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

(2016) Yun Lin et al.   Immunity & Ageing

TCR  repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition

(2015) H. M. Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Narrowing of Human Influenza A Virus-Specific T Cell Receptor α and β Repertoires with Increasing Age

(2015) Anna Gil et al.   JOURNAL OF VIROLOGY

Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach

(2015) Daniel J. Laydon et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

(2015) Jörg J. Goronzy et al.   Genome Medicine

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Towards error-free profiling of immune repertoires

(2014) Mikhail Shugay et al.   NATURE METHODS

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating the Diversity, Completeness, and Cross-Reactivity of the T Cell Repertoire

(2013) Veronika I. Zarnitsyna et al.   Frontiers in Immunology

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Statistical inference of the generation probability of T-cell receptors from sequence repertoires

(2012) A. Murugan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the Composition of the Preimmune Repertoire of T Cells Specific for Peptide–Major Histocompatibility Complex Ligands

(2010) Marc K. Jenkins et al.   Annual Review of Immunology

Overlap and Effective Size of the Human CD8+ T Cell Receptor Repertoire

(2010) H. S. Robins et al.   Science Translational Medicine

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing

(2009) J. D. Freeman et al.   GENOME RESEARCH