Article
Immunology
Chenfeng He, Michael J. Malone, Ben S. Wendel, Ke-Yue Ma, Daniel Del Alcazar, David B. Weiner, Philip L. De Jager, Perla M. Del Rio-Estrada, Yuria Ablanedo-Terrazas, Gustavo Reyes-Teran, Laura F. Su, Ning Jiang
Summary: Follicular-helper T cells, a vital part of adaptive immunity, have complex and plastic functions, but study limitations have hindered a comprehensive understanding. CXCR3-expressing T-FH cells in chronic infection show abnormal accumulation in lymphoid tissues, suggesting potential functional differences that may enhance defense.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Rami Bechara, Alexia Feray, Marc Pallardy
Summary: Allergic reactions to drugs and chemicals are mediated by specific T cells and it is unclear whether there is a common occurrence of thymic selection of drug/chemical-specific T cells. Recent observations suggest that T-cell receptor recognition of hapten-modified peptides may play a crucial role in drug/chemical allergy. This understanding could lead to efficient strategies for allergy diagnosis and predicting the immunogenic potential of new chemicals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Menghua Lyu, Shiyu Wang, Kai Gao, Longlong Wang, Xijun Zhu, Ya Liu, Meiniang Wang, Xiao Liu, Bin Li, Lei Tian
Summary: Through single-cell RNA-seq and TCR sequencing, this study investigated the subsets of CD4+ T cells during CMV infection and found that Tregs predominated in the reactivated cells, with clonal expansion confirmed in CD4+ CTL1 and CD4+ CTL2 cells. These findings provide insights into the roles of CD4+ T cells in CMV infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Aviv Omer, Ayelet Peres, Oscar L. Rodriguez, Corey T. Watson, William Lees, Pazit Polak, Andrew M. Collins, Gur Yaari
Summary: Adaptive immune receptor repertoire sequencing (AIRR-seq) is crucial for studying immune system dynamics. In this study, a B cell pipeline was adapted for genotype and haplotype inference of undocumented alleles in T cell receptor (TCR) data sets. The results revealed a rich picture of germline variability, and showed how a single nucleotide polymorphism dramatically affects the composition of the repertoire.
Article
Immunology
Mikiya Tsunoda, Hiroyasu Aoki, Haruka Shimizu, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha
Summary: Temporal analysis of T cell receptor (TCR) repertoire is important for monitoring changes in antigen-specific T cells in cancer patients. However, lack of experimental models for temporal analysis within a homogeneous population limits understanding of the relationship between TCR repertoire changes and antitumor responses. Bilateral tumor model showed highly similar T-cell clones in bilateral tumors and different patterns in draining lymph nodes, suggesting independent induction of tumor-reactive T cell clones in each lymph node.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Pingping Wang, Xiyun Jin, Wenyang Zhou, Meng Luo, Zhaochun Xu, Chang Xu, Yiqun Li, Kexin Ma, Huimin Cao, Yan Huang, Guangfu Xue, Shuilin Jin, Huan Nie, Qinghua Jiang
Summary: This study analyzed the TCR repertoire in COVID-19 patients using single-cell V(D)J sequencing and found distinct T cell clonal expansion as well as significant changes in VJ gene combinations. Moreover, preferential usage of V and J gene segments was observed in samples infected by different viruses, providing novel insights on the immune response in COVID-19.
Review
Immunology
Hiroyasu Aoki, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha
Summary: CD8(+) T cells are crucial for the antitumor immune response. TCR repertoire analysis allows for a better understanding of the response of tumor-specific T cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pavel Shelyakin, Ksenia R. Lupyr, Evgeny S. Egorov, Ilya A. Kofiadi, Dmitriy B. Staroverov, Sofya A. Kasatskaya, Valeriia V. Kriukova, Irina A. Shagina, Ekaterina M. Merzlyak, Tatiana O. Nakonechnaya, Elena A. Latysheva, Irina A. Manto, Musa R. Khaitov, Sergey A. Lukyanov, Dmitriy M. Chudakov, Olga Britanova
Summary: The interplay between T- and B-cell compartments during naive, effector and memory T cell maturation is critical for a balanced immune response. Primary B-cell immunodeficiency arising from X-linked agammaglobulinemia (XLA) offers a model to explore B cell impact on T cell subsets, starting from the thymic selection. The findings suggest active B cell involvement in CD4 T cell subsets maturation, including B cell-dependent expansion of the naive Treg TCR repertoire that enables better control of self-reactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hao H. Yiu, Louis N. Schoettle, Marlene Garcia-Neuer, Joseph N. Blattman, Philip L. F. Johnson
Summary: This passage discusses the diversity generation of T-cell receptors in the adaptive immune system and the differences among various receptor types, focusing on the presence of public receptor sequences in different contexts and the factors influencing their abundance. Thymic or peripheral selection is identified as a significant factor in increasing the abundances of public TCR sequences.
Article
Biology
George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G. Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi
Summary: This study demonstrates the significant impact of preexisting memory CD4 T cell clones on vaccine-induced immunity to hepatitis B. The presence of these clones can predict the strength and timing of the immune response to vaccination.
Review
Immunology
Nan -ping Weng
Summary: A large number of diverse alpha beta T cell receptors (TCRs) are generated during T cell development through V(D)J recombination, providing protection against pathogens and cancer cells. The TCR repertoire, encompassing all TCRs in an individual's T cells, is estimated to be at least 3.8 x 10(8) despite the presence of around 4 x 10(11) T cells in the adult human body. Changes in the diversity of the TCR repertoire are more noticeable with age, while the number of circulating T cells may slightly decrease.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Immunology
Mateusz Pospiech, Mukund Tamizharasan, Yu-Chun Wei, Advaith Maya Sanjeev Kumar, Mimi Lou, Joshua Milstein, Houda Alachkar
Summary: This study examined the association between TCR repertoire features in adult AML patients and their clinical and molecular characteristics using two computational tools. The study found that unique TCR clones were correlated with patients' white blood cell counts and blast percentages, and also correlated with T cells inhibitory signal genes. These findings suggest the presence of exhausted T cell phenotypes in AML.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Emil Lagumdzic, Clara Pernold, Marta Viano, Simone Olgiati, Michael W. Schmitt, Kerstin H. Mair, Armin Saalmueller
Summary: Pigs have the potential to be a valuable research model for studying human diseases, pharmacology, and transplantation. This study aimed to better understand the porcine immune system by analyzing the transcriptomes of different subsets of porcine CD8(+) T cells. The results showed distinct gene expression patterns in different subsets, providing valuable information for further research on porcine immune cell subsets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Robert Dixon, Stephen G. Preston, Stefan Dascalu, Patrik G. Flammer, Steven R. Fiddaman, Kirstie McLoughlin, Amy Boyd, Jiri Volf, Ivan Rychlik, Michael B. Bonsall, Bernd Kaspers, Adrian L. Smith
Summary: This study reveals that chicken TCR gamma locus has undergone tandem duplication events that have shaped its evolution. Repertoire sequencing shows large differences in the usage of individual TRGV genes across various tissues, with TRGV3.3 dominating every tissue. The application of repertoire analysis in chickens with a high circulating gamma delta phenotype is important for understanding the functional diversity of these cells and their potential in improving health.
Article
Immunology
Cheol-Hwa Hong, Hong-Seon Pyo, In-Cheol Baek, Tai-Gyu Kim
Summary: The study developed a novel TCR cloning system that successfully obtained and studied specific TCR pairs using an improved Jurkat cell line and reverse TCR cloning technology. This system provides valuable information for TCR repertoire analysis by NGS and the development of TCR-T therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Qiantao Wang, Joshua A. Rackers, Chenfeng He, Rui Qi, Christophe Narth, Louis Lagardere, Nohad Gresh, Jay W. Ponder, Jean-Philip Piquemal, Pengyu Ren
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2015)
Article
Immunology
Geoffrey T. Hart, Munir Akkaya, Asiya S. Chida, Chungwen Wei, Scott A. Jenks, Christopher Tipton, Chenfeng He, Ben S. Wendel, Jeff Skinner, Gunjan Arora, Kassoum Kayentao, Aissata Ongoiba, Ogobara Doumbo, Boubacar Traore, David L. Narum, Ning Jiang, Peter D. Crompton, Ignacio Sanz, Susan K. Pierce
JOURNAL OF IMMUNOLOGY
(2016)
Article
Cell Biology
Shu-Qi Zhang, Patricia Parker, Ke-Yue Ma, Chenfeng He, Qian Shi, Zhonghao Cui, Chad M. Williams, Ben S. Wendel, Amanda I. Meriwether, Mary Alice Salazar, Ning Jiang
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Multidisciplinary Sciences
Ben S. Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M. Hernandez, Ke-Yue Ma, Eugene W. Liu, Jun Xiao, Peter D. Crompton, Susan K. Pierce, Pengyu Ren, Keke Chen, Ning Jiang
NATURE COMMUNICATIONS
(2017)
Article
Immunology
Chad M. Williams, Alexandra A. Schonnesen, Shu-Qi Zhang, Ke-Yue Ma, Chenfeng He, Tori Yamamoto, S. Gail Eckhardt, Christopher A. Klebanoff, Ning Jiang
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Ben S. Wendel, Chenfeng He, Peter D. Crompton, Susan K. Pierce, Ning Jiang
FRONTIERS IN IMMUNOLOGY
(2017)
Meeting Abstract
Oncology
Ning Jiang, Shu-qi Zhang, Chenfeng He, Eric Sun, Mingliang Zhang, Weiping Jia
Article
Multidisciplinary Sciences
Chenfeng He, Ying-Xin Li, Guangxin Zhang, Zuguang Gu, Rong Yang, Jie Li, Zhi John Lu, Zhi-Hua Zhou, Chenyu Zhang, Jin Wang
Article
Multidisciplinary Sciences
Jackson Nowotny, Avery Wells, Oluwatosin Oluwadare, Lingfei Xu, Renzhi Cao, Tuan Trieu, Chenfeng He, Jianlin Cheng
SCIENTIFIC REPORTS
(2016)
Article
Biotechnology & Applied Microbiology
Shu-Qi Zhang, Ke-Yue Ma, Alexandra A. Schonnesen, Mingliang Zhang, Chenfeng He, Eric Sun, Chad M. Williams, Weiping Jia, Ning Jiang
NATURE BIOTECHNOLOGY
(2018)
Meeting Abstract
Immunology
Chad Manjeot Williams, Keyue Ma, Chenfeng He, Eric Sun, Shuqi Zhang, Ning Jiang
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Ben S. Wendel, Daniel del Alcazar, Chenfeng He, Perla M. Del Rio-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M. Hernandez, Ke-Yue Ma, Michael R. Betts, Laura Pulido, Jun Huang, Phyllis A. Gimotty, Gustavo Reyes-Teran, Ning Jiang, Laura F. Su
SCIENCE IMMUNOLOGY
(2018)
Meeting Abstract
Immunology
Ning Jiang, Di Wu, Mingjuan Qu, Ben Wendel, Chenfeng He
JOURNAL OF IMMUNOLOGY
(2015)