Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress

(2022) Connor Quinn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamic human liver proteome atlas reveals functional insights into disease pathways

(2022) Lili Niu et al.   Molecular Systems Biology

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

Identification of a Pyroptosis-Related Prognostic Signature Combined With Experiments in Hepatocellular Carcinoma

(2022) Huihui Li et al.   Frontiers in Molecular Biosciences

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration

(2022) Stefan Gerhardy et al.   Nature Communications

A folate receptor 3 SNP promotes mitochondria‐induced clonogenicity of CML leukemia cells: Implications for treatment free remission

(2021) Na Shen et al.   Clinical and Translational Medicine

Progress on haptoglobin and metabolic diseases

(2021) Bao-Nian Wan et al.   World Journal of Diabetes

Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice

(2021) Noreen McBrearty et al.   NEOPLASIA

ENO3 promoted the progression of NASH by negatively regulating ferroptosis via elevation of GPX4 expression and lipid accumulation

(2021) Di Lu et al.   Annals of Translational Medicine

Collagen VI as a driver and disease biomarker in human fibrosis

(2021) Lynn Williams et al.   FEBS Journal

TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment

(2021) Jeff Yat-Fai Chung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Biomarker discovery for chronic liver diseases by multi-omics – a preclinical case study

(2020) Daniel Veyel et al.   Scientific Reports

Exploiting the folate receptor α in oncology

(2020) Mariana Scaranti et al.   Nature Reviews Clinical Oncology

Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3

(2020) Ren Yoshitomi et al.   Scientific Reports

Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?

(2020) David H Ipsen et al.   Advances in Nutrition

Metabolic drivers of non-alcoholic fatty liver disease

(2020) Kendra K. Bence et al.   Molecular Metabolism

The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

(2020) Parth Trivedi et al.   Cell Metabolism

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

A Phenotypic Switch of Differentiated Glial Cells to Dedifferentiated Cells Is Regulated by Folate Receptor α

(2019) Sarah Monick et al.   STEM CELLS

The Impact of Obesity and Type 2 Diabetes on Chronic Liver Disease

(2019) Zobair M. Younossi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease

(2018) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

(2018) Hanghang Zhang et al.   CELL

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2018) Zobair M. Younossi et al.   TRANSPLANTATION

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

(2017) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Bioinformatics microarray analysis and identification of gene expression profiles associated with cirrhotic liver

(2016) Kun-Ming Chan et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition

(2016) Xuelian Li et al.   Scientific Reports

Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha

(2015) Mariann F. Hansen et al.   CELLULAR SIGNALLING

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

(2015) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Nonalcoholic steatohepatitis in precision medicine: Unraveling the factors that contribute to individual variability

(2015) John D. Clarke et al.   PHARMACOLOGY & THERAPEUTICS

Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease

(2014) W. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

(2013) Jason R. Clapper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Structural basis for molecular recognition of folic acid by folate receptors

(2013) Chen Chen et al.   NATURE

Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

(2013) Julie R. Graham et al.   PLoS One

Erosive Arthritis and Hepatic Granuloma Formation Induced by Peptidoglycan Polysaccharide in Rats Is Aggravated by Prasugrel Treatment

(2013) Analia E. Garcia et al.   PLoS One

Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions

(2012) Paola Picotti et al.   NATURE METHODS

Nuclear localization of folate receptor alpha: a new role as a transcription factor

(2012) Vanda Boshnjaku et al.   Scientific Reports

Substrate-induced remodeling of the active site regulates human HTRA1 activity

(2011) Linda Truebestein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous effusions

(2009) Yuan Yuan et al.   HUMAN PATHOLOGY

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Disruption of the latent transforming growth factor-β binding protein-1 gene causes alteration in facial structure and influences TGF-β bioavailability

(2007) Falko Drews et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH