Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint

Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cells

(2023) Megan M. Wyatt et al.   MOLECULAR THERAPY

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

(2021) Teruyuki Sano et al.   Cell Reports

Differential splicing analysis based on isoforms expression with NBSplice

(2020) Gabriela Alejandra Merino et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Regulation of T Helper Cell Fate by TCR Signal Strength

(2020) Nayan D. Bhattacharyya et al.   Frontiers in Immunology

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

(2020) Lin Wu et al.   CELL

Microbial guardians of skin health

(2019) Apollo Stacy et al.   SCIENCE

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

(2019) Sara Omenetti et al.   IMMUNITY

CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter

(2019) Martina Kunkl et al.   Frontiers in Immunology

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

(2018) Fiamma Salerno et al.   NATURE IMMUNOLOGY

Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting

(2018) Wiebke Manuela Schulze et al.   Nature Communications

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation

(2018) Shankar Revu et al.   Cell Reports

Nuclear phosphoinositide regulation of chromatin

(2017) Bree L. Hamann et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PTEN drives Th17 cell differentiation by preventing IL-2 production

(2017) Hyeong Su Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear speckles: molecular organization, biological function and role in disease

(2017) Lukasz Galganski et al.   NUCLEIC ACIDS RESEARCH

ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes

(2017) Martina Kunkl et al.   Frontiers in Immunology

Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study

(2016) Eva Havrdová et al.   JOURNAL OF NEUROLOGY

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

PIP kinases define PI4,5P2 signaling specificity by association with effectors

(2015) Suyong Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

(2015) Dhavalkumar D. Patel et al.   IMMUNITY

Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+T Cell Fate Decisions

(2015) William F. Hawse et al.   JOURNAL OF IMMUNOLOGY

CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes

(2014) Cristina Camperio et al.   IMMUNOLOGY LETTERS

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphatidylinositol 4–Phosphate 5–Kinase α and Vav1 Mutual Cooperation in CD28-Mediated Actin Remodeling and Signaling Functions

(2014) Michela Muscolini et al.   JOURNAL OF IMMUNOLOGY

Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2

(2014) L. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR signal quantity and quality in CD4+ T cell differentiation

(2014) Noah J. Tubo et al.   TRENDS IN IMMUNOLOGY

Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling

(2013) Yue Sun et al.   BIOESSAYS

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Posttranscriptional Gene Regulation of IL-17 by the RNA-Binding Protein HuR Is Required for Initiation of Experimental Autoimmune Encephalomyelitis

(2013) J. Chen et al.   JOURNAL OF IMMUNOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

(2013) Marie Hallais et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The human cap-binding complex is functionally connected to the nuclear RNA exosome

(2013) Peter Refsing Andersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Low-strength T-cell activation promotes Th17 responses

(2010) H. A. Purvis et al.   BLOOD

Cutting Edge: CTLA-4-B7 Interaction Suppresses Th17 Cell Differentiation

(2010) H. Ying et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Autoimmunity risk alleles in costimulation pathways

(2009) Lisa M. Maier et al.   IMMUNOLOGICAL REVIEWS

CD28 Co-Stimulation Down Regulates Th17 Development

(2009) Salim Bouguermouh et al.   PLoS One

Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum

(2009) Christy A. Barlow et al.   TRENDS IN CELL BIOLOGY

Posttranscriptional regulation of IL-13 in T cells: Role of the RNA-binding protein HuR

(2008) Vincenzo Casolaro et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY