Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling

Phosphoinositide Signaling Regulates the Exocyst Complex and Polarized Integrin Trafficking in Directionally Migrating Cells

(2012) Narendra Thapa et al.   DEVELOPMENTAL CELL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type I  in vivo

(2012) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

Star-PAP Control of BIK Expression and Apoptosis Is Regulated by Nuclear PIPKIα and PKCδ Signaling

(2012) Weimin Li et al.   MOLECULAR CELL

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

(2012) Yueguang Rong et al.   NATURE CELL BIOLOGY

NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P2 Is Essential for AMPA Receptor Endocytosis during LTD

(2012) Takamitsu Unoki et al.   NEURON

PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells

(2012) Narendra Thapa et al.   Cell Adhesion & Migration

A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain

(2011) Lok Hang Mak et al.   ACS Chemical Biology

Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans

(2011) Yang Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphatidylinositol 4,5-Bisphosphate Alters Synaptotagmin 1 Membrane Docking and Drives Opposing Bilayers Closer Together

(2011) Weiwei Kuo et al.   BIOCHEMISTRY

PIPKIγ Regulates β-Catenin Transcriptional Activity Downstream of Growth Factor Receptor Signaling

(2011) Mark Schramp et al.   CANCER RESEARCH

Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission

(2011) Belle Chang-Ileto et al.   DEVELOPMENTAL CELL

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2synthesis

(2011) Kyle R Legate et al.   EMBO JOURNAL

OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin

(2011) Mariella Vicinanza et al.   EMBO JOURNAL

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion

(2011) Zhao Wang et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

(2011) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

(2011) Xunhao Xiong et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of two novel mutations in the OCRL1 gene in two Chinese families with Lowe syndrome

(2011) YAO-HUA KE et al.   NEPHROLOGY

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells

(2011) Peter J. Wen et al.   Nature Communications

Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and In Vivo Infiltration

(2010) Wenwen Xu et al.   IMMUNITY

Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain

(2010) Laura A. Volpicelli-Daley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I PIPK-α regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation

(2010) Wei-Ting Chao et al.   JOURNAL OF CELL BIOLOGY

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets

(2010) Ronald S. Flannagan et al.   JOURNAL OF CELL BIOLOGY

Challenges in studying phospholipid signaling

(2010) Carsten Schultz   Nature Chemical Biology

Two novel phosphatidylinositol-4-phosphate 5-kinase type Iγ splice variants expressed in human cells display distinctive cellular targeting

(2009) Nicholas J. Schill et al.   BIOCHEMICAL JOURNAL

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis

(2009) Yuntao S. Mao et al.   JOURNAL OF CELL BIOLOGY

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

(2009) Frédéric Saltel et al.   JOURNAL OF CELL BIOLOGY

Unbalancing the Phosphatidylinositol-4,5-bisphosphate–Cofilin Interaction Impairs Cell Steering

(2009) Shirley Leyman et al.   MOLECULAR BIOLOGY OF THE CELL

A Reciprocal Interdependence between Nck and PI(4,5)P2 Promotes Localized N-WASp-Mediated Actin Polymerization in Living Cells

(2009) Gonzalo M. Rivera et al.   MOLECULAR CELL

Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease

(2009) Heather J. McCrea et al.   PHYSIOLOGY

Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum

(2009) Christy A. Barlow et al.   TRENDS IN CELL BIOLOGY

Role of Type Iα Phosphatidylinositol-4-Phosphate 5-Kinase in Insulin Secretion, Glucose Metabolism, and Membrane Potential in INS-1 β-Cells

(2008) Jiping Zhang et al.   ENDOCRINOLOGY

Differential Roles of Phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3in Plasma Membrane Targeting of C2 Domains

(2008) Debasis Manna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion

(2008) Declan J. James et al.   JOURNAL OF CELL BIOLOGY

A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs

(2008) David L. Mellman et al.   NATURE

Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

(2008) Diego E Berman et al.   NATURE NEUROSCIENCE

Loss of PIP5KI  demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA