CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28

(2018) Nicla Porciello et al.   Nature Communications

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation

(2018) Shankar Revu et al.   Cell Reports

IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulateIl17a/ftranscription

(2018) Sarah K. Whitley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation

(2017) Subhash K. Tripathi et al.   Cell Reports

ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes

(2017) Martina Kunkl et al.   Frontiers in Immunology

CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling

(2016) Nicla Porciello et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways

(2016) Xiang Xiao et al.   IMMUNITY

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells

(2016) Romain Roncagalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor

(2016) Emily E. Way et al.   Scientific Reports

The multifaceted role of PIP2 in leukocyte biology

(2015) Loretta Tuosto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets

(2015) Wenkai Ren et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance

(2015) Rajatava Basu et al.   NATURE IMMUNOLOGY

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

Th17 plasticity: pathophysiology and treatment of chronic inflammatory disorders

(2014) Lorenzo Cosmi et al.   CURRENT OPINION IN PHARMACOLOGY

CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes

(2014) Cristina Camperio et al.   IMMUNOLOGY LETTERS

Phosphatidylinositol 4–Phosphate 5–Kinase α and Vav1 Mutual Cooperation in CD28-Mediated Actin Remodeling and Signaling Functions

(2014) Michela Muscolini et al.   JOURNAL OF IMMUNOLOGY

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

(2013) Shigenori Nagai et al.   Annals of the New York Academy of Sciences

Differential induction of IL-17, IL-10, and IL-9 in human T helper cells by B7h and B7.1

(2013) Riccardo Mesturini et al.   CYTOKINE

T helper cells plasticity in inflammation

(2013) Lorenzo Cosmi et al.   CYTOMETRY PART A

Phosphatidylinositol 4-Phosphate 5-Kinase   Activation Critically Contributes to CD28-Dependent Signaling Responses

(2013) M. Muscolini et al.   JOURNAL OF IMMUNOLOGY

Generation of Th17 from human naive CD4+ T cells preferentially occurs from FOXP3+ Tregs upon costimulation via CD28 or CD5

(2012) M. Ayyoub et al.   BLOOD

Human Th17 subsets

(2012) Federica Sallusto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?

(2012) Annalisa Camporeale   Frontiers in Bioscience-Landmark

Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion

(2012) Veronica Santarlasci et al.   IMMUNITY

Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

(2012) Jatinder K. Juss et al.   PLoS One

Defining the human T helper 17 cell phenotype

(2012) Francesco Annunziato et al.   TRENDS IN IMMUNOLOGY

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

A novel association between filamin A and NF-κB inducing kinase couples CD28 to inhibitor of NF-κB kinase α and NF-κB activation

(2011) Michela Muscolini et al.   IMMUNOLOGY LETTERS

Akt Fine-tunes NF-κB-dependent Gene Expression during T Cell Activation

(2011) Jing Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of the Th17 immune response by IKKα

(2011) Li Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

(2011) Qingguo Ruan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis

(2011) F. Jadidi-Niaragh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Low-strength T-cell activation promotes Th17 responses

(2010) H. A. Purvis et al.   BLOOD

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

(2010) Kiyoshi Hirahara et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

NF-κB family of transcription factors: Biochemical players of CD28 co-stimulation

(2010) Loretta Tuosto   IMMUNOLOGY LETTERS

Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK

(2009) W. Jin et al.   BLOOD

Human Th17 cells: Are they different from murine Th17 cells?

(2009) Francesco Annunziato et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Role of Th17 in Neuroimmune Disorders: Target for CAM Therapy. Part II

(2009) Aristo Vojdani et al.   Evidence-based Complementary and Alternative Medicine

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy

(2009) Joseph R. Podojil et al.   IMMUNOLOGICAL REVIEWS

Properties and origin of human Th17 cells

(2009) Sergio Romagnani et al.   MOLECULAR IMMUNOLOGY

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

(2009) Sung-Gyoo Park et al.   NATURE IMMUNOLOGY

CD28 Co-Stimulation Down Regulates Th17 Development

(2009) Salim Bouguermouh et al.   PLoS One

Genome-wide discovery of functional transcription factor binding sites by comparative genomics: The case of Stat3

(2009) F. Vallania et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

(2008) Satoshi Serada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA