DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11

Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants

(2022) Jacquelyn R. Bedsaul et al.   iScience

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein

(2022) Jia Tong Loh et al.   Frontiers in Immunology

CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma

(2022) Takuro Kameda et al.   Communications Biology

DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils

(2021) Jia Tong Loh et al.   Cell Death & Disease

Protein Kinase CK1α Sustains B-Cell Receptor Signaling in Mantle Cell Lymphoma

(2021) Sabrina Manni et al.   Frontiers in Oncology

Characterization of MC903 induced Atopic Dermatitis‐like skin inflammation in mice

(2020) Katharine Chu et al.   FASEB JOURNAL

Emerging Roles of Downstream of Kinase 3 in Cell Signaling

(2020) Jia Tong Loh et al.   Frontiers in Immunology

Towards personalized treatment in atopic dermatitis

(2019) Jorien van der Schaft et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Dok3–protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity

(2019) Jia Tong Loh et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11)

(2018) Harjit Dadi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dupilumab progressively improves systemic and cutaneous abnormalities in atopic dermatitis patients

(2018) Emma Guttman-Yassky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease

(2018) Batsukh Dorjbal et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

(2018) Jacquelyn R. Bedsaul et al.   Frontiers in Immunology

Germline hypomorphic CARD11 mutations in severe atopic disease

(2017) Chi A Ma et al.   NATURE GENETICS

Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells

(2017) Changwei Li et al.   Cell Death & Disease

Expert Perspectives on Management of Moderate-to-Severe Atopic Dermatitis: A Multidisciplinary Consensus Addressing Current and Emerging Therapies

(2017) Mark Boguniewicz et al.   Journal of Allergy and Clinical Immunology-In Practice

Recent considerations in the use of recombinant interferon gamma for biological therapy of atopic dermatitis

(2016) Kanwaljit Brar et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis—PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

(2016) Antonella Muraro et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intracellular Delivery of Anti-pPKCθ (Thr538) via Protein Transduction Domain Mimics for Immunomodulation

(2016) E Ilker Ozay et al.   MOLECULAR THERAPY

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2016) Eric L. Simpson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association study of recalcitrant atopic dermatitis in Korean children

(2015) Kyung Won Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization

(2015) Shinji Noda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

(2015) Lavinia Paternoster et al.   NATURE GENETICS

Genome-wide association studies of atopic dermatitis

(2014) Mayumi Tamari et al.   JOURNAL OF DERMATOLOGY

A PP4 Holoenzyme Balances Physiological and Oncogenic Nuclear Factor-Kappa B Signaling in T Lymphocytes

(2012) Markus Brechmann et al.   IMMUNITY

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

(2012) Tomomitsu Hirota et al.   NATURE GENETICS

DOK3 Negatively Regulates LPS Responses and Endotoxin Tolerance

(2012) Qisheng Peng et al.   PLoS One

Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3–positive regulatory versus TH2 effector cells to cause allergy

(2011) John A. Altin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY