DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils

S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis

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JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

(2020) Azucena Salas et al.   Nature Reviews Gastroenterology & Hepatology

Emerging Roles of Downstream of Kinase 3 in Cell Signaling

(2020) Jia Tong Loh et al.   Frontiers in Immunology

Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models

(2019) Susan J. Robertson et al.   Cell Reports

Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment

(2019) Christina Eftychi et al.   IMMUNITY

Dok3–protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity

(2019) Jia Tong Loh et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding the pathogenesis of Flavobacterium psychrophilum using the rainbow trout monocyte/macrophage-like cell line, RTS11, as an infection model

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S100A8/A9 in Inflammation

(2018) Siwen Wang et al.   Frontiers in Immunology

Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

(2018) Yu Fujita et al.   Cell Reports

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting

(2018) Alexander R. Moschen et al.   Nature Reviews Gastroenterology & Hepatology

Current and emerging therapeutic targets for IBD

(2017) Markus Neurath   Nature Reviews Gastroenterology & Hepatology

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

(2017) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

A distinct bacterial dysbiosis associated skin inflammation in ovine footrot

(2017) Grazieli Maboni et al.   Scientific Reports

Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22

(2016) Masazumi Waseda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proinflammatory cytokine and cytokine receptor gene expression kinetics following challenge with Flavobacterium psychrophilum in resistant and susceptible lines of rainbow trout ( Oncorhynchus mykiss )

(2016) Ivan Kutyrev et al.   FISH & SHELLFISH IMMUNOLOGY

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

(2016) Floris Imhann et al.   GUT

Fungal microbiota dysbiosis in IBD

(2016) Harry Sokol et al.   GUT

Mucosa-attached bacterial community in Crohn's disease coheres with the clinical disease activity index

(2016) Holger Schäffler et al.   Environmental Microbiology Reports

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR−/HER2+breast cancers

(2015) Ruth Rodriguez-Barrueco et al.   GENES & DEVELOPMENT

Human calprotectin is an iron-sequestering host-defense protein

(2015) Toshiki G Nakashige et al.   Nature Chemical Biology

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

(2014) Nicole Reichardt et al.   ISME Journal

TLR9 Ligands Induce S100A8 in Macrophages via a STAT3-Dependent Pathway which Requires IL-10 and PGE2

(2014) Kenneth Hsu et al.   PLoS One

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

(2013) S. M. Damo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

A Physical Interaction Between the Adaptor Proteins DOK3 and DAP12 Is Required to Inhibit Lipopolysaccharide Signaling in Macrophages

(2013) Q. Peng et al.   Science Signaling

The Mycobiome: Influencing IBD Severity

(2012) David L. Moyes et al.   Cell Host & Microbe

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

The gut microbiota in IBD

(2012) Chaysavanh Manichanh et al.   Nature Reviews Gastroenterology & Hepatology

Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus

(2011) Thomas E. Kehl-Fie et al.   Cell Host & Microbe

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

(2010) Wendy S. Garrett et al.   Cell Host & Microbe

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

(2009) Saeid Ghavami et al.   CELL RESEARCH

Immune Responses to the Microbiota at the Intestinal Mucosal Surface

(2009) Breck A. Duerkop et al.   IMMUNITY

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE