Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants

Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency

(2021) Henry Y. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant NegativeCARD11 Allele

(2021) Shelby M. Hutcherson et al.   JOURNAL OF IMMUNOLOGY

TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease

(2021) Thomas J. O’Neill et al.   Science Immunology

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

(2020) Stuart G. Tangye et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain

(2020) Rebekka Schairer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human inborn errors of immunity: An expanding universe

(2020) Luigi D. Notarangelo et al.   Science Immunology

CADINS in an Adult with Chronic Sinusitis and Atopic Disease

(2020) Neema Izadi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Multiplexed Functional Assessment of Genetic Variants in CARD11

(2020) Iana Meitlis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Germline CBM-opathies: From immunodeficiency to atopy

(2019) Henry Y. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling

(2019) Zhaoquan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells

(2019) Torben Gehring et al.   Cell Reports

Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11)

(2018) Harjit Dadi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome

(2018) Liron David et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Control of Epstein–Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease

(2018) Swadhinya Arjunaraja et al.   Frontiers in Immunology

Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease

(2018) Batsukh Dorjbal et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular architecture and regulation of BCL10-MALT1 filaments

(2018) Florian Schlauderer et al.   Nature Communications

Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling

(2018) Mélanie Juilland et al.   Frontiers in Immunology

Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

(2018) Jacquelyn R. Bedsaul et al.   Frontiers in Immunology

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells

(2018) Marie Lork et al.   CELLULAR IMMUNOLOGY

BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

(2018) Thomas Seeholzer et al.   Frontiers in Immunology

Post-translational Modifications of the CARMA1-BCL10-MALT1 Complex in Lymphocytes and Activated B-Cell Like Subtype of Diffuse Large B-Cell Lymphoma

(2018) An Thys et al.   Frontiers in Oncology

Germline hypomorphic CARD11 mutations in severe atopic disease

(2017) Chi A Ma et al.   NATURE GENETICS

Intrinsic Plasma Cell Differentiation Defects in B Cell Expansion with NF-κB and T Cell Anergy Patient B Cells

(2017) Swadhinya Arjunaraja et al.   Frontiers in Immunology

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome

(2016) Isabel Meininger et al.   BIOLOGICAL CHEMISTRY

Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain

(2016) Rakhi P. Jattani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements

(2016) Rakhi P. Jattani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling

(2016) Yong-Kang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mild B-cell lymphocytosis in patients with a CARD11 C49Y mutation

(2015) David Buchbinder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181

(2015) Sarah M. Pedersen et al.   MOLECULAR AND CELLULAR BIOLOGY

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency

(2014) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis

(2014) Andrew S. Brohl et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Binomial distribution for quantification of protein subunits in biological Nanoassemblies and functional nanomachines

(2014) Huaming Fang et al.   Nanomedicine-Nanotechnology Biology and Medicine

T Cell Receptor-Dependent Activation of mTOR Signaling in T Cells Is Mediated by Carma1 and MALT1, But Not Bcl10

(2014) K. S. Hamilton et al.   Science Signaling

Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency

(2013) Johann Greil et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects

(2013) Polina Stepensky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination

(2013) Christiane Pelzer et al.   NATURE IMMUNOLOGY

Congenital B cell lymphocytosis explained by novel germlineCARD11mutations

(2012) Andrew L. Snow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Quantitative Signaling Screen Identifies CARD11 Mutations in the CARD and LATCH Domains That Induce Bcl10 Ubiquitination and Human Lymphoma Cell Survival

(2012) W. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Structural Insights into the Assembly of CARMA1 and BCL10

(2012) Siwei Li et al.   PLoS One

Oncogenic CARD11 Mutations Induce Hyperactive Signaling by Disrupting Autoinhibition by the PKC-Responsive Inhibitory Domain

(2010) Rebecca L. Lamason et al.   BIOCHEMISTRY

The Dynamic Distribution of CARD11 at the Immunological Synapse Is Regulated by the Inhibitory Kinesin GAKIN

(2010) Rebecca L. Lamason et al.   MOLECULAR CELL

CARMA1-mediated NF-κB and JNK activation in lymphocytes

(2009) Marzenna Blonska et al.   IMMUNOLOGICAL REVIEWS

A20 Negatively Regulates T Cell Receptor Signaling to NF- B by Cleaving Malt1 Ubiquitin Chains

(2009) M. Duwel et al.   JOURNAL OF IMMUNOLOGY

The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF- B Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for Association

(2008) R. R. McCully et al.   MOLECULAR AND CELLULAR BIOLOGY