Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation

Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

(2022) Yan Qiu et al.   DIABETOLOGIA

Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model

(2022) Xinyan Huang et al.   Science China-Life Sciences

PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure

(2022) Guoqing Tang et al.   Science China-Life Sciences

Induced regulatory T cells suppress Tc1 cells through TGF-β signaling to ameliorate STZ-induced type 1 diabetes mellitus

(2021) Li Zhou et al.   Cellular & Molecular Immunology

Temporal Metabolic and Transcriptomic Characteristics Crossing Islets and Liver Reveal Dynamic Pathophysiology in Diet-induced Diabetes

(2021) Rui Gao et al.   iScience

Type 1 diabetes mellitus: much progress, many opportunities

(2021) Alvin C. Powers   JOURNAL OF CLINICAL INVESTIGATION

Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury

(2021) Xiaoyu Xue et al.   Science China-Life Sciences

Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision

(2021) Hengwei Jin et al.   Science China-Life Sciences

Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells

(2021) Vipul Shrivastava et al.   Scientific Reports

The Plasticity of Pancreatic β-Cells

(2021) Norikiyo Honzawa et al.   Metabolites

Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

(2021) Zheng Ruan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CD81 marks immature and dedifferentiated pancreatic β-cells

(2021) Ciro Salinno et al.   Molecular Metabolism

Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation

(2021) Patricio Atanes et al.   PHARMACOLOGY & THERAPEUTICS

Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering

(2021) Nicole A J Krentz et al.   Lancet Diabetes & Endocrinology

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells

(2020) Xisheng Li et al.   Stem Cell Reports

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches

(2020) Lei Zhang et al.   Journal of Hematology & Oncology

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

(2019) Yewei Ji et al.   NATURE IMMUNOLOGY

Tailored chromatin modulation to promote tissue regeneration

(2019) Paloma Martinez-Redondo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Myc Is Required for Adaptive ß-Cell Replication in Young Mice but Is not Sufficient in One-Year-Old Mice Fed with a High-Fat Diet

(2019) Carolina Rosselot et al.   DIABETES

New Frontiers in the Treatment of Type 1 Diabetes

(2019) Jeremy T. Warshauer et al.   Cell Metabolism

The somatostatin-secreting pancreatic δ-cell in health and disease

(2018) Patrik Rorsman et al.   Nature Reviews Endocrinology

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

(2018) Noel G. Morgan et al.   DIABETOLOGIA

Beta cell dedifferentiation in T2D patients with adequate glucose control and non-diabetic chronic pancreatitis

(2018) Jiajun Sun et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreas regeneration

(2018) Qiao Zhou et al.   NATURE

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation

(2018) Santhanam Shanmughapriya et al.   Nature Communications

Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease

(2018) Miao Cui et al.   DEVELOPMENT

Low Level Insulin Content Within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes

(2018) Carol J. Lam et al.   DIABETES

Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance

(2018) Emilie Courty et al.   DIABETES

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis

(2017) Carol J Lam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic β cell identity requires continual repression of non–β cell programs

(2016) Giselle Domínguez Gutiérrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

(2016) Ja Young Kim-Muller et al.   Nature Communications

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Pancreatic β-Cell Proliferation in Obesity

(2014) Amelia K. Linnemann et al.   Advances in Nutrition

Predominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes

(2013) S. Yoneda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Recovery from diabetes in neonatal mice after a low-dose streptozotocin treatment

(2012) Masateru Kataoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Metabolic differentiation in the embryonic retina

(2012) Michalis Agathocleous et al.   NATURE CELL BIOLOGY

Murine models for pharmacological studies of the metabolic syndrome

(2012) Lyne Fellmann et al.   PHARMACOLOGY & THERAPEUTICS

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

(2010) Stephen C. Hanley et al.   ENDOCRINOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES