Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision

Lineage tracing on transcriptional landscapes links state to fate during differentiation

(2020) Caleb Weinreb et al.   SCIENCE

Bi-directional differentiation of single bronchioalveolar stem cells during lung repair

(2020) Kuo Liu et al.   Cell Discovery

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

(2020) Maria C. Basil et al.   Cell Stem Cell

Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies

(2020) Kuo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

(2020) Sarah Bowling et al.   CELL

Tamoxifen-Activated Cre Impairs Retinal Angiogenesis Independently of Gene Deletion

(2020) James T Brash et al.   CIRCULATION RESEARCH

Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis

(2020) Yan Li et al.   DEVELOPMENTAL CELL

Single-cell RNA-seq analysis revealed long-lasting adverse effects of tamoxifen on neurogenesis in prenatal and adult brains

(2020) Chia-Ming Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recording EMT Activity by Lineage Tracing during Metastasis

(2020) Pauline Vieugué et al.   DEVELOPMENTAL CELL

Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration

(2019) Ximeng Han et al.   Stem Cell Reports

Stem cells: past, present, and future

(2019) Wojciech Zakrzewski et al.   Stem Cell Research & Therapy

Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

(2019) Qiaozhen Liu et al.   NATURE GENETICS

Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo

(2019) Isabelle Salwig et al.   EMBO JOURNAL

Cellular Reprogramming as a Therapeutic Target in Cancer

(2019) Shumin Xiong et al.   TRENDS IN CELL BIOLOGY

Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages

(2019) Yan Li et al.   CIRCULATION RESEARCH

Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double

(2019) Huan Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

Modulating Cell Fate as a Therapeutic Strategy

(2018) Brian Lin et al.   Cell Stem Cell

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

(2018) Xing Deng et al.   Cell Stem Cell

Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases

(2018) Yan Li et al.   CIRCULATION

Clonal analysis of lineage fate in native haematopoiesis

(2018) Alejo E. Rodriguez-Fraticelli et al.   NATURE

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Live cell-lineage tracing and machine learning reveal patterns of organ regeneration

(2018) Oriol Viader-Llargués et al.   eLife

A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme

(2018) Kuo Liu et al.   DEVELOPMENT

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

(2017) Weike Pei et al.   NATURE

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

(2017) Kevin P O'Rourke et al.   NATURE BIOTECHNOLOGY

Enhancing the precision of genetic lineage tracing using dual recombinases

(2017) Lingjuan He et al.   NATURE MEDICINE

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target SlugCLINICAL PERSPECTIVE

(2016) Rachel K. Hopper et al.   CIRCULATION

Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells

(2016) Guang Li et al.   DEVELOPMENTAL CELL

Genetic lineage tracing identifies endocardial origin of liver vasculature

(2016) Hui Zhang et al.   NATURE GENETICS

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes

(2015) Qiaozhen Liu et al.   CELL RESEARCH

Cellular Origin and Developmental Program of Coronary Angiogenesis

(2015) X. Tian et al.   CIRCULATION RESEARCH

Expanding the power of recombinase-based labeling to uncover cellular diversity

(2015) N. W. Plummer et al.   DEVELOPMENT

Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance

(2015) Linda Madisen et al.   NEURON

Resident c-kit+ cells in the heart are not cardiac stem cells

(2015) Nishat Sultana et al.   Nature Communications

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Absence of Evidence Is Not Evidence of Absence

(2014) Bernardo Nadal-Ginard et al.   CIRCULATION RESEARCH

Letter by Molkentin Regarding Article, “The Absence of Evidence Is Not Evidence of Absence: The Pitfalls of Cre Knock-Ins in the c-Kit Locus”

(2014) Jeffery D. Molkentin   CIRCULATION RESEARCH

Clonal tracing of Sox9+liver progenitors in mouse oval cell injury

(2014) Branden D. Tarlow et al.   HEPATOLOGY

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

(2013) Georgina M. Ellison et al.   CELL

Are Resident c-Kit + Cardiac Stem Cells Really All That Are Needed to Mend a Broken Heart?

(2013) Jeffery D. Molkentin et al.   CIRCULATION RESEARCH

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

MADM-ML, a Mouse Genetic Mosaic System with Increased Clonal Efficiency

(2013) Astra Henner et al.   PLoS One

Lineage Tracing

(2012) Kai Kretzschmar et al.   CELL

Islet1 Derivatives in the Heart Are of Both Neural Crest and Second Heart Field Origin

(2012) Kurt A. Engleka et al.   CIRCULATION RESEARCH

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

(2012) Panteleimon Rompolas et al.   NATURE

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

(2011) Chris Jopling et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis

(2010) Kim B Jensen et al.   Nature Protocols

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages

(2009) Vitor H. Sousa et al.   CEREBRAL CORTEX

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis

(2009) Masakazu Yamamoto et al.   GENESIS

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Role of the ATP-Binding Cassette Transporter Abcg2 in the Phenotype and Function of Cardiac Side Population Cells

(2008) Otmar Pfister et al.   CIRCULATION RESEARCH

Redefining the serotonergic system by genetic lineage

(2008) Patricia Jensen et al.   NATURE NEUROSCIENCE