Imidazole-Thiazolidine-2,4-dione Conjugated 1,2,3-Triazole Derivatives as Tubulin Aiming Antiproliferative Agents

New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

(2022) Hamada H. H. Mohammed et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of Coumarin‐Thiazolidine‐2,4‐dione‐Pyrazole Hybrids as Epidermal Growth Factor Receptor (EGFR)‐Targeted Agents

(2022) Kotni Hari Gangadhar et al.   ChemistrySelect

One‐pot Synthesis of Some New Isatin‐1,2,4‐Oxadiazole Hybrids as VEGFR‐2 Aiming Anticancer Agents

(2022) Sunitha Boda et al.   ChemistrySelect

In vitro Anticancer and Insilico Studies of Quinoxaline‐sulfonyl‐1,2,4‐triazole Hybrids

(2022) Gouthami Dasari et al.   ChemistrySelect

Synthesis of Novel 1,2,3-Triazole Derivatives of Tolbutamide and Evaluation of Their Antibacterial, Antioxidant, and DPP-4 Inhibitory Activity

(2022) Swathi Chirra et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

New molecular hybrids containing benzimidazole, thiazolidine-2,4-dione and 1,2,4-oxadiazole as EGFR directing cytotoxic agents

(2022) kudapa Venu et al.   TETRAHEDRON

Exploration of thiazolidine‐2,4‐diones as tyrosine kinase inhibitors: Design, synthesis, ADMET, docking, and antiproliferative evaluations

(2022) Nada A. A. M. Aziz et al.   ARCHIV DER PHARMAZIE

Synthesis of Some New Indole-1,3,4-Oxadiazole Hybrids as Tubulin Polymerization Inhibitors

(2022) Sunitha Boda et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

In Vitro Anticancer and In Silico Studies of Some 1,4‐Benzoxazine‐1,2,4‐oxadiazole Hybrids

(2021) Ashwini Nagaraju et al.   ChemistrySelect

Imidazoles as Potential Anticancer Agents: An Update on Recent Studies

(2021) Pankaj Sharma et al.   MOLECULES

Synthesis of Quinoxlines Containing 1,2,3-Triazoles and Their Anti-Bacterial and Anti-Cancer Activity

(2021) D. Gouthami et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

1,2,3‐Triazole hybrids as anticancer agents: A review

(2021) Mohammad Mahboob Alam   ARCHIV DER PHARMAZIE

Benzothiazole-[1,2,3]triazolo[5,1-a]isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein

(2021) Manoj Kumar N et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site

(2020) Xi Hu et al.   BIOORGANIC CHEMISTRY

Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin

(2020) Pan Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of substituted N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)cinnamides as tubulin polymerization inhibitors

(2020) Kavitha Donthiboina et al.   BIOORGANIC CHEMISTRY

Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors

(2019) Dong-Jun Fu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains

(2019) Fatima Naaz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones

(2019) Perihan A. Elzahhar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin

(2019) Qinghui Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3-(((9H-purin-6-yl)amino)methyl)-4,6-dimethylpyridin-2(1H)-one derivatives as novel tubulin polymerization inhibitors for treatment of cancer

(2019) Qiangsheng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy

(2019) Dongsheng Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 1-(benzofuran-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole derivatives as tubulin polymerization inhibitors

(2019) Zhi-Yuan Qi et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell lines

(2019) Mohamed S.H. Salem et al.   BIOORGANIC CHEMISTRY

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

(2019) Murat Bozdag et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors

(2019) Liancheng Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells

(2019) Zhaoshi Bai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

(2019) Zhi Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of imidazo[2,1- b ]thiazole-benzimidazole conjugates as microtubule-targeting agents

(2018) Mirza Feroz Baig et al.   BIOORGANIC CHEMISTRY

Imidazopyridine linked triazoles as tubulin inhibitors, effectively triggering apoptosis in lung cancer cell line

(2018) Ibrahim Bin Sayeed et al.   BIOORGANIC CHEMISTRY

How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors

(2017) Sandra N. Milik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Homology Modeling in Drug Discovery-an Update on the Last Decade

(2017) Geraldene Munsamy et al.   Letters in Drug Design & Discovery

GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway

(2017) Jing Xie et al.   Oncotarget

Synthesis and biological evaluation of pyrazolo–triazole hybrids as cytotoxic and apoptosis inducing agents

(2015) T. Srinivasa Reddy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent developments in tubulin polymerization inhibitors: An overview

(2014) Ramandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazolidine-2,4-diones as multi-targeted scaffold in medicinal chemistry: Potential anticancer agents

(2014) Vivek Asati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, cytotoxic effects and tubulin polymerization inhibition of 1,4-disubstituted 1,2,3-triazole analogs of 2-methoxyestradiol

(2014) Eirik Johansson Solum et al.   STEROIDS

3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: Design, synthesis and biological characterization

(2011) Kai Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activities

(2010) Qiu Zhang et al.   CURRENT PHARMACEUTICAL DESIGN

N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines

(2010) Jonathan A. Stefely et al.   JOURNAL OF MEDICINAL CHEMISTRY

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

(2009) Y.-W. Lin et al.   BLOOD

Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

(2009) Z. Beharry et al.   MOLECULAR CANCER THERAPEUTICS