New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

New 1,2,3-Triazoles from (R)-Carvone: Synthesis, DFT Mechanistic Study and In Vitro Cytotoxic Evaluation

(2022) Ali Oubella et al.   MOLECULES

Paclitaxel anticancer activity is enhanced by the MEK 1/2 inhibitor PD98059 in vitro and by PD98059-loaded nanoparticles in BRAFV600E melanoma-bearing mice

(2021) Aml I. Mekkawy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

1,2,3‐Triazole hybrids as anticancer agents: A review

(2021) Mohammad Mahboob Alam   ARCHIV DER PHARMAZIE

Global colorectal cancer burden in 2020 and projections to 2040

(2021) Yue Xi et al.   Translational Oncology

Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors

(2020) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226

(2020) Heba F. Ashour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Urea Linked Ciprofloxacin-Chalcone Hybrids having Antiproliferative Topoisomerases I/II Inhibitory Activities and Caspases-Mediated Apoptosis

(2020) Hamada H.H. Mohammed et al.   BIOORGANIC CHEMISTRY

Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors

(2020) Amr K.A. Bass et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole tethered chalcone hybrids as potential anticancer agents

(2020) Nirmala Gurrapu et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis and biological evaluation of novel c-Met/HDAC dual inhibitors

(2020) Yuhong Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments

(2020) Ashraf K. El-Damasy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs

(2020) Emma Baglini et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Design, synthesis, anticancer and antioxidant activities of amide linked 1,4-disubstituted 1,2,3-triazoles

(2020) C.P. Kaushik et al.   JOURNAL OF MOLECULAR STRUCTURE

An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent

(2019) Wang Yan et al.   INVESTIGATIONAL NEW DRUGS

Triazole derivatives and their antiplasmodial and antimalarial activities

(2019) Xue-Mei Chu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Repositioning of fluoroquinolones from antibiotic to anti-cancer agents: An underestimated truth

(2019) Vikas Yadav et al.   BIOMEDICINE & PHARMACOTHERAPY

Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids

(2019) Bo Zhang   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies

(2019) Saeed Emami et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Towards anticancer fluoroquinolones: A review article

(2019) Mohamed A. A. Abdel‐Aal et al.   ARCHIV DER PHARMAZIE

Modification of 7-piperazinylquinolone antibacterials to promising anticancer lead compounds: Synthesis and in vitro studies

(2019) Hamideh Ahadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

(2019) Zhi Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Advancements in 1,4-Disubstituted 1H-1,2,3-Triazoles as Potential Anticancer Agents

(2018) Kashmiri Lal et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors

(2018) Jiwei Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Current Trends and Future Directions of Fluoroquinolones

(2018) Hamada H. H. Mohammed et al.   CURRENT MEDICINAL CHEMISTRY

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

(2018) Ye Tian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells

(2018) Fatma F. Ahmed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual or multi-targeting inhibitors: The next generation anticancer agents

(2018) Nulgumnalli Manjunathaiah Raghavendra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation

(2018) Hanane Kaoukabi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Eco-friendly one-pot synthesis of some new pyrazolo[1,2-b]phthalazinediones with antiproliferative efficacy on human hepatic cancer cell lines

(2018) Huda R. M. Rashdan et al.   Green Chemistry Letters and Reviews

A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

(2018) Piyush N. Kalaria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

(2018) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triazole derivatives and their anti-tubercular activity

(2017) Shu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

(2017) Jawaid Akhtar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New antiproliferative 7-(4-( N -substituted carbamoylmethyl)piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G 2 /M phase

(2016) Hamada H.H. Mohammed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel antifungal agents: a patent review (2013 - present)

(2016) María Victoria Castelli et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation

(2015) Vikas Yadav et al.   BMC CANCER

Triazole: A Promising Antitubercular Agent

(2015) Rangappa S. Keri et al.   Chemical Biology & Drug Design

Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies

(2015) Alaa A.-M. Abdel-Aziz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole Moiety

(2015) Sobhi Gomha et al.   MOLECULES

Recent developments in biological activities of chalcones: A mini review

(2014) Parvesh Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

[10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells

(2014) Min Ju Ryu et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anti-inflammatory and antioxidant activity of ring-A-monosubstituted chalcone derivatives

(2014) Hiba Iqbal et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines

(2013) Narva Suresh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity

(2013) Mohamed Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and nonlinear optical absorption of novel chalcone derivative compounds

(2013) K. Mani Rahulan et al.   OPTICS AND LASER TECHNOLOGY

Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide-Alkyne Cycloadditions

(2013) B. T. Worrell et al.   SCIENCE

Photophysical and photochemical investigations on triazole ring linked chalcone containing polymethacrylates

(2012) S. Balamurugan et al.   POLYMER

Synthesis of lipophilic dimeric C-7/C-7-linked ciprofloxacin and C-6/C-6-linked levofloxacin derivatives. Versatile in vitro biological evaluations of monomeric and dimeric fluoroquinolone derivatives as potential antitumor, antibacterial or antimycobacterial agents

(2011) Joëlle Azéma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials

(2011) James C. McPherson et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer

(2010) Vivek R. Yadav et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: Synthesis and in vitro biological evaluation as potential antitumor agents

(2009) Joëlle Azéma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-Substituted piperazinyl quinolones as potential cytotoxic agents: Structure–activity relationships study

(2008) Alireza Foroumadi et al.   BIOMEDICINE & PHARMACOTHERAPY

Quinolones as enhancers of camptothecin-induced cytotoxic and anti-topoisomerase I effects

(2007) Debby Reuveni et al.   BIOCHEMICAL PHARMACOLOGY