New molecular hybrids containing benzimidazole, thiazolidine-2,4-dione and 1,2,4-oxadiazole as EGFR directing cytotoxic agents

Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR)

(2021) Mar’iyah Najihah Abdullah et al.   Chemical Biology & Drug Design

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

(2020) Dima A. Sabbah et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery

(2020) Karol Biernacki et al.   Pharmaceuticals

Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones

(2019) Perihan A. Elzahhar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors

(2019) İsmail Celik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole in the targeted anticancer drug discovery

(2019) Adileh Ayati et al.   Future Medicinal Chemistry

2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy

(2019) Dongsheng Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents

(2019) Nilüfer Bayrak et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell lines

(2019) Mohamed S.H. Salem et al.   BIOORGANIC CHEMISTRY

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

(2019) Murat Bozdag et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of stable benzimidazole derivatives bearing pyrazole as anticancer and EGFR receptor inhibitors

(2018) Md. Jawaid Akhtar et al.   BIOORGANIC CHEMISTRY

Part III: Novel checkpoint kinase 2 (Chk2) inhibitors; design, synthesis and biological evaluation of pyrimidine-benzimidazole conjugates

(2018) Shadia A. Galal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Mercaptobenzimidazole Schiff Bases: Design, Synthesis, Antimicrobial Studies and Anticancer Activity on HCT-116 Cell Line

(2018) Sumit Tahlan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A Mild and Efficient One-Pot Preparation of 1,2,4-Oxadiazoles from Nitriles and Carboxylic Acids Using Vilsmeier Reagent

(2018) Maaroof Zarei   ChemistrySelect

Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs

(2017) Shadia A. Galal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors

(2017) Sandra N. Milik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway

(2017) Jing Xie et al.   Oncotarget

Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity

(2016) Li Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery

(2015) Adile Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review

(2015) Geeta Yadav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Galeterone (TOK-001 or VN/124-1) for the Treatment of All Stages of Prostate Cancer

(2015) Vincent C. O. Njar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimal use of bendamustine in hematologic disorders: Treatment recommendations from an international consensus panel – an update

(2015) Bruce D. Cheson et al.   LEUKEMIA & LYMPHOMA

Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions

(2015) Monika Gaba et al.   MEDICINAL CHEMISTRY RESEARCH

Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry

(2014) Rangappa S. Keri et al.   Chemical Biology & Drug Design

Thiazolidine-2,4-diones as multi-targeted scaffold in medicinal chemistry: Potential anticancer agents

(2014) Vivek Asati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole: An emerging scaffold for analgesic and anti-inflammatory agents

(2014) Monika Gaba et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Minimalist Hybrid Ligand/Receptor-Based Pharmacophore Model for CXCR4 Applied to a Small-Library of Marine Natural Products Led to the Identification of Phidianidine A as a New CXCR4 Ligand Exhibiting Antagonist Activity

(2013) Rosa Maria Vitale et al.   ACS Chemical Biology

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

(2013) E. K. Keeton et al.   BLOOD

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

(2012) Jin H. Park et al.   BIOCHEMICAL JOURNAL

Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists

(2012) Jun Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives

(2012) Carlos Hernández-Covarrubias et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: Design, synthesis and biological characterization

(2011) Kai Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARγ ligands

(2010) Cleiton Diniz Barros et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The discovery and structure–activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia

(2010) Karine Lavrador-Erb et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Suppression of NF-κB and GSK-3β is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone

(2010) Jung Ok Ban et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activities

(2010) Qiu Zhang et al.   CURRENT PHARMACEUTICAL DESIGN

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

(2009) Y.-W. Lin et al.   BLOOD

Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

(2009) Francine Walker et al.   HUMAN PATHOLOGY

Bendamustine: Rebirth of an Old Drug

(2009) Bruce D. Cheson et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

(2009) Z. Beharry et al.   MOLECULAR CANCER THERAPEUTICS

Amphiregulin: Role in Mammary Gland Development and Breast Cancer

(2008) Jean McBryan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA