Exploration of thiazolidine‐2,4‐diones as tyrosine kinase inhibitors: Design, synthesis, ADMET, docking, and antiproliferative evaluations

Design, synthesis, molecular docking, in silico ADMET profile and anticancer evaluations of sulfonamide endowed with hydrazone-coupled derivatives as VEGFR-2 inhibitors

(2021) Asmaa M Sayed et al.   BIOORGANIC CHEMISTRY

Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations

(2021) Fathalla Khedr et al.   ARCHIV DER PHARMAZIE

Design, synthesis, anticancer, and docking of some S‐ and/or N‐heterocyclic derivatives as VEGFR‐2 inhibitors

(2021) Khaled El‐Adl et al.   ARCHIV DER PHARMAZIE

Design, synthesis, molecular docking and in silico ADMET profile of pyrano[2,3-d]pyrimidine derivatives as antimicrobial and anticancer agents

(2021) Nour E.A. Abd El-Sattar et al.   BIOORGANIC CHEMISTRY

5‐(4‐Methoxybenzylidene)thiazolidine‐2,4‐dione‐derived VEGFR‐2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluations

(2020) Khaled El‐Adl et al.   ARCHIV DER PHARMAZIE

Design, synthesis, molecular docking, and anticancer evaluations of 1‐benzylquinazoline‐2,4(1 H ,3 H )‐dione bearing different moieties as VEGFR‐2 inhibitors

(2020) Khaled El‐Adl et al.   ARCHIV DER PHARMAZIE

Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme

(2020) Khaled El-Adl et al.   BIOORGANIC CHEMISTRY

Dual EGFR/VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC

(2020) Xiuning Le et al.   Journal of Thoracic Oncology

Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors

(2020) Khaled El-Adl et al.   BIOORGANIC CHEMISTRY

Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers

(2019) Souad A. Elmetwally et al.   BIOORGANIC CHEMISTRY

Development of a series of novel 4-anlinoquinazoline derivatives possessing quinazoline skeleton: Design, synthesis, EGFR kinase inhibitory efficacy, and evaluation of anticancer activities in vitro

(2017) Jin Chang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2

(2017) Hai-Qi Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of N -(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC

(2017) Yongfei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-Benzylidene-2,4-thiazolidenedione derivatives: Design, synthesis and evaluation as inhibitors of angiogenesis targeting VEGR-2

(2016) Umesh Bhanushali et al.   BIOORGANIC CHEMISTRY

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

(2016) Sahar M. Abou-Seri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Five-Year Survival in EGFR -Mutant Metastatic Lung Adenocarcinoma Treated with EGFR-TKIs

(2016) Jessica J. Lin et al.   Journal of Thoracic Oncology

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

(2015) Vera A. Machado et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

(2015) Douglas E. V. Pires et al.   JOURNAL OF MEDICINAL CHEMISTRY

AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer

(2015) Pasi A. Jänne et al.   NEW ENGLAND JOURNAL OF MEDICINE

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily

(2015) Valentina Gandin et al.   Scientific Reports

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

(2014) Zheng Zhao et al.   ACS Chemical Biology

A new dawn for the use of thiazolidinediones in cancer therapy

(2014) Hardik Joshi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

(2013) Maria Letícia de Castro Barbosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oral Delivery of Lipophilic Drugs: The Tradeoff between Solubility Increase and Permeability Decrease When Using Cyclodextrin-Based Formulations

(2013) Avital Beig et al.   PLoS One

Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway

(2013) Zhiyu Wang et al.   PLoS One

Role of angiogenesis in the pathogenesis of cancer

(2012) Paulo M. Hoff et al.   CANCER TREATMENT REVIEWS

Vascular Endothelial Growth Factor (VEGF), VEGF Receptors and Their Inhibitors for Antiangiogenic Tumor Therapy

(2011) Satoru Takahashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis

(2011) Annette K. Larsen et al.   PHARMACOLOGY & THERAPEUTICS

The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796

(2010) Justin Dietrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Vascular Endothelial Growth Factor and Its Type 2 Receptor in Hepatocellular Carcinoma

(2010) E. S. Gershtein et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors

(2010) Kyungik Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

EGFR T790M Mutation: A Double Role in Lung Cancer Cell Survival?

(2010) Kenichi Suda et al.   Journal of Thoracic Oncology

[4-(6,7-Disubstituted quinazolin-4-ylamino)phenyl] carbamic acid esters: a novel series of dual EGFR/VEGFR-2 tyrosine kinase inhibitors

(2010) Antonio Garofalo et al.   MedChemComm

Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro

(2009) Divya K. Shah et al.   FERTILITY AND STERILITY

Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2

(2008) Qing-Qing Xie et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING