Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

(2022) Vassily Trubetskoy et al.   NATURE

An integrated framework for local genetic correlation analysis

(2022) Josefin Werme et al.   NATURE GENETICS

Genetic analysis of over half a million people characterises C-reactive protein loci

(2022) Saredo Said et al.   Nature Communications

Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders

(2022) William R. Reay et al.   Science Advances

Increased immune cell and altered microglia and neurogenesis transcripts in an Australian schizophrenia subgroup with elevated inflammation

(2022) Hayley F. North et al.   SCHIZOPHRENIA RESEARCH

Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank

(2021) Maria C. Pitharouli et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

(2021) Niamh Mullins et al.   NATURE GENETICS

Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis

(2021) Ryad Tamouza et al.   Translational Psychiatry

Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation

(2021) Attila Szabo et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory Markers in Depression: a Meta-Analysis of Mean Differences and Variability in 5,166 Patients and 5,083 Controls

(2020) Emanuele F. Osimo et al.   BRAIN BEHAVIOR AND IMMUNITY

Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model

(2020) Dominic Holland et al.   PLoS Genetics

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

(2020) Na Cai et al.   HUMAN MOLECULAR GENETICS

The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology

(2020) Olav B. Smeland et al.   Nature Reviews Neurology

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics

(2020) Maya Ghoussaini et al.   NUCLEIC ACIDS RESEARCH

The Gene Ontology resource: enriching a GOld mine

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Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

(2019) Simon Haworth et al.   Nature Communications

Exploring Comorbidity Within Mental Disorders Among a Danish National Population

(2019) Oleguer Plana-Ripoll et al.   JAMA Psychiatry

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk

(2019) Jennie G Pouget et al.   HUMAN MOLECULAR GENETICS

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

(2019) Oleksandr Frei et al.   Nature Communications

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

(2018) Marco Del Giudice et al.   BRAIN BEHAVIOR AND IMMUNITY

Psychiatric genetics and the structure of psychopathology

(2018) Jordan W. Smoller et al.   MOLECULAR PSYCHIATRY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

(2018) Douglas Teixeira Leffa et al.   NEUROIMMUNOMODULATION

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits

(2018) Yan Zhang et al.   NATURE GENETICS

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data

(2018) Daniel S. Tylee et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies

(2018) Tiago Reis Marques et al.   PSYCHOLOGICAL MEDICINE

Mendelian Randomization

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex

(2016) Yan-Chun Li et al.   NEUROPHARMACOLOGY

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study

(2016) Bram. P. Prins et al.   PLOS MEDICINE

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

(2013) Harvey A Whiteford et al.   LANCET

Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

(2013) Ole A. Andreassen et al.   PLoS Genetics

Age-specific trends of survival in metastatic breast cancer: 26 years longitudinal data from a population-based cancer registry in Stockholm, Sweden

(2011) Theodoros Foukakis et al.   BREAST CANCER RESEARCH AND TREATMENT

Longitudinal trends in cardiovascular mortality and blood pressure levels, prevalence, awareness, treatment, and control of hypertension in the Czech population from 1985 to 2007/2008

(2010) Renata Cífková et al.   JOURNAL OF HYPERTENSION