Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

(2021) David Amar et al.   Nature Communications

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

(2021) Vasiliki Lagou et al.   Nature Communications

The IL-6 antagonist tocilizumab is associated with worse depression and related symptoms in the medically ill

(2021) Jennifer M. Knight et al.   Translational Psychiatry

Depression and interleukin-6 signaling: A Mendelian Randomization Study

(2021) Kristen Kelly et al.   BRAIN BEHAVIOR AND IMMUNITY

Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

(2021) William R Reay et al.   eLife

Advancing the use of genome-wide association studies for drug repurposing

(2021) William R. Reay et al.   NATURE REVIEWS GENETICS

A robust and efficient method for Mendelian randomization with hundreds of genetic variants

(2020) Stephen Burgess et al.   Nature Communications

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

(2020) Yoonsu Cho et al.   Nature Communications

Cortisol, inflammatory biomarkers and neurotrophins in children and adolescents with attention deficit hyperactivity disorder (ADHD) in Taiwan

(2020) Jane Pei-Chen Chang et al.   BRAIN BEHAVIOR AND IMMUNITY

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

(2020) Enda M. Byrne et al.   MOLECULAR PSYCHIATRY

Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations

(2020) William R. Reay et al.   Translational Psychiatry

Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders

(2020) André F. Carvalho et al.   Translational Psychiatry

Longitudinal associations between circulating interleukin-6 and C-reactive protein in childhood, and eating disorders and disordered eating in adolescence

(2020) Francesca Solmi et al.   BRAIN BEHAVIOR AND IMMUNITY

The impact of tocilizumab on anxiety and depression in patients with rheumatoid arthritis

(2020) Shmuel Tiosano et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The Polygenic and Monogenic Basis of Blood Traits and Diseases

(2020) Dragana Vuckovic et al.   CELL

Effects of IL-6 Signaling Pathway Inhibition on Weight and BMI: A Systematic Review and Meta-Analysis

(2020) Olivia Patsalos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa

(2020) Danielle M. Adams et al.   NEUROPSYCHOPHARMACOLOGY

Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms

(2020) Nils Kappelmann et al.   JAMA Psychiatry

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

(2019) Dongmei Yu et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits

(2019) Eric R. Gamazon et al.   NATURE GENETICS

Mendelian randomization: the challenge of unobserved environmental confounds

(2019) Philipp D Koellinger et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

(2019) Hunna J. Watson et al.   NATURE GENETICS

Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates

(2019) Jessica M. B. Rees et al.   PLoS One

Commentary: CRP and schizophrenia: cause, consequence or confounding?

(2019) Symen Ligthart   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

(2019) Adrienne Tin et al.   NATURE GENETICS

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

(2019) Caroline M. Nievergelt et al.   Nature Communications

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

(2019) Phil H. Lee et al.   CELL

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

(2018) Marco Del Giudice et al.   BRAIN BEHAVIOR AND IMMUNITY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

Analysis of shared heritability in common disorders of the brain

(2018) et al.   SCIENCE

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Role of C-Reactive Protein at Sites of Inflammation and Infection

(2018) Nicola R. Sproston et al.   Frontiers in Immunology

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates

(2018) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

OUP accepted manuscript

(2018)   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review

(2018) Guillaume Fond et al.   Frontiers in Psychiatry

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

(2018) Symen Ligthart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings

(2018) Eleanor Sanderson et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Distinguishing genetic correlation from causation across 52 diseases and complex traits

(2018) Luke J. O’Connor et al.   NATURE GENETICS

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls

(2018) Isabella Jacomb et al.   Frontiers in Immunology

Body mass index in obsessive-compulsive disorder

(2018) Amitai Abramovitch et al.   JOURNAL OF AFFECTIVE DISORDERS

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

(2017) Stephen Burgess et al.   EPIDEMIOLOGY

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

(2017) Olena O Yavorska et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis

(2017) Paul D Arnold et al.   MOLECULAR PSYCHIATRY

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

(2017) Lasse Folkersen et al.   PLoS Genetics

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

(2017) Eleanor Wheeler et al.   PLOS MEDICINE

Inflammatory Biomarkers and Risk of Schizophrenia

(2017) Fernando Pires Hartwig et al.   JAMA Psychiatry

Body mass index moderates the relationship between C-reactive protein and depressive symptoms: evidence from the China Health and Retirement Longitudinal Study

(2017) Tingting Qin et al.   Scientific Reports

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Serum Uric Acid and Its Association with Longitudinal Cognitive Change Among Urban Adults

(2016) May A. Beydoun et al.   JOURNAL OF ALZHEIMERS DISEASE

Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex

(2016) Yan-Chun Li et al.   NEUROPHARMACOLOGY

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study

(2016) Bram. P. Prins et al.   PLOS MEDICINE

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

(2016) Jeroen Slaats et al.   PLoS Pathogens

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Fasting blood glucose and HbA1c in children with ADHD

(2015) Frank Lindblad et al.   PSYCHIATRY RESEARCH

Inflammatory cytokines and anorexia nervosa: A meta-analysis of cross-sectional and longitudinal studies

(2015) Marco Solmi et al.   PSYCHONEUROENDOCRINOLOGY

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

(2014) A Masi et al.   MOLECULAR PSYCHIATRY

An updated meta-analysis of oxidative stress markers in bipolar disorder

(2014) Nicole C. Brown et al.   PSYCHIATRY RESEARCH

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

A Better Coefficient of Determination for Genetic Profile Analysis

(2012) Sang Hong Lee et al.   GENETIC EPIDEMIOLOGY

Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia

(2012) M J Green et al.   MOLECULAR PSYCHIATRY

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

(2010) N J Timpson et al.   INTERNATIONAL JOURNAL OF OBESITY