Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
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Title
Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
Authors
Keywords
Heredity, Genome-wide association studies, Molecular genetics, Heterozygosity, Schizophrenia, Fourier analysis, Alzheimer's disease, Amyotrophic lateral sclerosis
Journal
PLoS Genetics
Volume 16, Issue 5, Pages e1008612
Publisher
Public Library of Science (PLoS)
Online
2020-05-20
DOI
10.1371/journal.pgen.1008612
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Note: Only part of the references are listed.- Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
- (2019) Mashaal Sohail et al. eLife
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- (2019) Jeremy J Berg et al. eLife
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- (2018) Luke M. Evans et al. NATURE GENETICS
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- (2018) Jeanne E. Savage et al. NATURE GENETICS
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- (2018) James J. Lee et al. NATURE GENETICS
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- (2018) Paul Mehta et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
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- (2018) Vitalay Fomin et al. MOLECULAR AND CELLULAR BIOLOGY
- Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits
- (2018) Yan Zhang et al. NATURE GENETICS
- SumHer better estimates the SNP heritability of complex traits from summary statistics
- (2018) Doug Speed et al. NATURE GENETICS
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- (2017) Katrina M de Lange et al. NATURE GENETICS
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- (2017) Suzanne Sniekers et al. NATURE GENETICS
- Concepts, estimation and interpretation of SNP-based heritability
- (2017) Jian Yang et al. NATURE GENETICS
- Reevaluation of SNP heritability in complex human traits
- (2017) Doug Speed et al. NATURE GENETICS
- Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
- (2017) Rahul S. Desikan et al. PLOS MEDICINE
- LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
- (2016) Jie Zheng et al. BIOINFORMATICS
- Genome-wide association study identifies 74 loci associated with educational attainment
- (2016) Aysu Okbay et al. NATURE
- Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
- (2016) Wouter van Rheenen et al. NATURE GENETICS
- Assessment of the genetic variance of late-onset Alzheimer's disease
- (2016) Perry G. Ridge et al. NEUROBIOLOGY OF AGING
- Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics
- (2016) Dominic Holland et al. Frontiers in Genetics
- A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait
- (2015) Luigi Palla et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
- (2015) Majid Nikpay et al. NATURE GENETICS
- LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
- (2015) Brendan K Bulik-Sullivan et al. NATURE GENETICS
- Limitations of GCTA as a solution to the missing heritability problem
- (2015) Siddharth Krishna Kumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identifying Causal Variants at Loci with Multiple Signals of Association
- (2014) F. Hormozdiari et al. GENETICS
- Defining the role of common variation in the genomic and biological architecture of adult human height
- (2014) Andrew R Wood et al. NATURE GENETICS
- The contribution of genetic variants to disease depends on the ruler
- (2014) John S. Witte et al. NATURE REVIEWS GENETICS
- Measuring missing heritability: Inferring the contribution of common variants
- (2014) David Golan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The burden of inflammatory bowel disease in Europe
- (2013) Johan Burisch et al. Journal of Crohns & Colitis
- Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
- (2013) Harvey A Whiteford et al. LANCET
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Alzheimer’s Disease: Analyzing the Missing Heritability
- (2013) Perry G. Ridge et al. PLoS One
- GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
- (2013) C. A. Rietveld et al. SCIENCE
- Polygenic Modeling with Bayesian Sparse Linear Mixed Models
- (2013) Xiang Zhou et al. PLoS Genetics
- Improved Heritability Estimation from Genome-wide SNPs
- (2012) Doug Speed et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
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- (2012) S Hong Lee et al. NATURE GENETICS
- Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
- (2012) Eli A Stahl et al. NATURE GENETICS
- Rates of Decline in Alzheimer Disease Decrease with Age
- (2012) Dominic Holland et al. PLoS One
- Estimating Missing Heritability for Disease from Genome-wide Association Studies
- (2011) Sang Hong Lee et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Comparison of Association Methods Correcting for Population Stratification in Case-Control Studies
- (2011) Chengqing Wu et al. ANNALS OF HUMAN GENETICS
- Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative
- (2011) Kathleen R. Merikangas et al. ARCHIVES OF GENERAL PSYCHIATRY
- HAPGEN2: simulation of multiple disease SNPs
- (2011) Zhan Su et al. BIOINFORMATICS
- Genomic inflation factors under polygenic inheritance
- (2011) Jian Yang et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Genome partitioning of genetic variation for complex traits using common SNPs
- (2011) Jian Yang et al. NATURE GENETICS
- GCTA: A Tool for Genome-wide Complex Trait Analysis
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- (2010) Tanya M. Teslovich et al. NATURE
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- Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
- (2009) Shaun M. Purcell et al. NATURE
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- (2009) Chris C. A. Spencer et al. PLoS Genetics
- Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
- (2008) Itsik Pe'er et al. GENETIC EPIDEMIOLOGY
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges
- (2008) Mark I. McCarthy et al. NATURE REVIEWS GENETICS
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