The Synergistic Effect of Nanocurcumin and Donepezil on Alzheimer's via PI3K/AKT/GSK-3β Pathway Modulating

Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration

(2022) Qiuzhi Zhou et al.   EBioMedicine

Advances in the development of new biomarkers for Alzheimer’s disease

(2022) Timofey O. Klyucherev et al.   Translational Neurodegeneration

Curcumin and Intestinal Oxidative Stress of Pigs With Intrauterine Growth Retardation: A Review

(2022) Xiaopeng Tang et al.   Frontiers in Nutrition

Application of curcumin nanoformulations in Alzheimer’s disease: prevention, diagnosis and treatment

(2022) Hongqian Lv et al.   NUTRITIONAL NEUROSCIENCE

Curcumin improves D-galactose and normal-aging associated memory impairment in mice: In vivo and in silico-based studies

(2022) Md. Ashrafur Rahman et al.   PLoS One

Protective effects of curcumin against traumatic brain injury

(2022) Danial Khayatan et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview

(2022) Giovanni Martemucci et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Leflunomide abrogates neuroinflammatory changes in a rat model of Alzheimer’s disease: the role of TNF-α/NF-κB/IL-1β axis inhibition

(2022) Menna Nafea et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Tau and GSK-3β are Critical Contributors to α-Synuclein-Mediated Post-Stroke Brain Damage

(2022) Suresh L. Mehta et al.   NEUROMOLECULAR MEDICINE

Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer’s Disease

(2021) Ines ELBini-Dhouib et al.   MOLECULES

Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling

(2021) Wedad S. Sarawi et al.   MOLECULES

The clinical correlation of proinflammatory and anti-inflammatory biomarkers with Alzheimer disease: a meta-analysis

(2021) Urati Anuradha et al.   NEUROLOGICAL SCIENCES

WIN55,212-2 Attenuates Cognitive Impairments in AlCl3 + d-Galactose-Induced Alzheimer’s Disease Rats by Enhancing Neurogenesis and Reversing Oxidative Stress

(2021) Onesimus Mahdi et al.   Biomedicines

Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling

(2021) Jieun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage

(2021) Cong Yang et al.   International Journal of Nanomedicine

Protective Effect of Natural Antioxidant, Curcumin Nanoparticles, and Zinc Oxide Nanoparticles against Type 2 Diabetes-Promoted Hippocampal Neurotoxicity in Rats

(2021) Shaymaa Abdulmalek et al.   Pharmaceutics

Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease

(2021) Li Zeng et al.   Molecular Therapy-Nucleic Acids

Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation

(2020) Wen-xuan Jian et al.   ACTA PHARMACOLOGICA SINICA

The β-secretase BACE1 in Alzheimer’s disease

(2020) Harald Hampel et al.   BIOLOGICAL PSYCHIATRY

Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature

(2020) Monica A. Silva et al.   Journal of Chemical Information and Modeling

Glycogen synthase kinase-3 signaling in Alzheimer's disease

(2020) Elisabetta Lauretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nanocurcumin improved glucose metabolism in streptozotocin-induced diabetic rats: a comparison study with Gliclazide

(2020) Mohamed Afifi et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Association between aluminum in drinking water and incident Alzheimer’s disease in the Canadian Study of Health and Aging cohort

(2020) Nicole Van Dyke et al.   NEUROTOXICOLOGY

GSK3β and Tau Protein in Alzheimer’s Disease and Epilepsy

(2020) Danira Toral-Rios et al.   Frontiers in Cellular Neuroscience

Effects of Long-Term Supplementation with Aluminum or Selenium on the Activities of Antioxidant Enzymes in Mouse Brain and Liver

(2020) Ilona Sadauskiene et al.   Catalysts

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

(2020) Przemysław Duda et al.   Cells

Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches

(2020) Thai-Son Tran et al.   MOLECULES

Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients

(2020) Hamed Valizadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Aβ1-42 increases the expression of neural KATP subunits Kir6.2/SUR1 via the NF-κB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons

(2019) Y Li et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

(2019) Hanie Yavarpour-Bali et al.   International Journal of Nanomedicine

Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

(2019) Takehiro Kawashiri et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Nitric oxide might be an inducing factor in cognitive impairment in Alzheimer's disease via downregulating the monocarboxylate transporter 1

(2019) Xiaoyi Tang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage

(2019) YongYue Gao et al.   Frontiers in Neuroscience

d -galactose and aluminium chloride induced rat model with cognitive impairments

(2018) Samaila Musa Chiroma et al.   BIOMEDICINE & PHARMACOTHERAPY

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

The Mechanisms of Action of Curcumin in Alzheimer’s Disease

(2017) Mengxi Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia

(2017) Yoshinori Haraguchi et al.   Journal of Neuroinflammation

Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats

(2017) Ayodele Jacob Akinyemi et al.   NEUROTOXICOLOGY

Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines

(2017) Yan-Mei Liu et al.   Scientific Reports

Glycogen synthase kinase-3β regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer’s disease

(2016) Almudena Fuster-Matanzo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer’s Disease

(2016) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin, an active component of turmeric (Curcuma longa), and its effects on health

(2015) Betül Kocaadam et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Increased iPLA2 activity and levels of phosphorylated GSK3B in platelets are associated with donepezil treatment in Alzheimer’s disease patients

(2015) L. L. Talib et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Effects of aluminum on amyloid-beta aggregation in the context of Alzheimer’s disease

(2015) Qiulan Zhang et al.   Arabian Journal of Chemistry

Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats

(2014) Hongbin Ni et al.   JOURNAL OF SPINAL CORD MEDICINE

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

(2013) Shashi Kant Tiwari et al.   ACS Nano

Histopathological alterations after a growth promoter boldenone injection in rabbits

(2013) Ehab Tousson   TOXICOLOGY AND INDUSTRIAL HEALTH

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

(2012) Kwok Kin Cheng et al.   AAPS Journal

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Curcumin Nanoparticles: Preparation, Characterization, and Antimicrobial Study

(2011) Bhawana et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

Formulation Design and Photochemical Studies on Nanocrystal Solid Dispersion of Curcumin with Improved Oral Bioavailability

(2009) Satomi Onoue et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus

(2008) So Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY