Review
Medicine, Research & Experimental
Weihua Zhan, Song Zhang
Summary: TRIM proteins play key roles in various biological processes and are closely related to tumor development; Alterations in TRIM gene and protein levels frequently emerge in tumors and affect tumor progression; TRIM proteins maintain the balance between tumor suppressive and tumor promoting genes through ubiquitylation events.
Article
Biochemistry & Molecular Biology
Xin Bai, Jianming Tang
Summary: This article provides a comprehensive review of the roles and molecular mechanisms of tripartite motif (TRIM) proteins in breast cancer. It highlights their importance in breast cancer treatment and suggests that TRIM proteins may be ideal targets for breast cancer therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Oncology
Jessica Elisabetta Esposito, Vincenzo De Iuliis, Francesco Avolio, Eliana Liberatoscioli, Riccardo Pulcini, Simona Di Francesco, Alfonso Pennelli, Stefano Martinotti, Elena Toniato
Summary: This review provides an overview of the structural organization, biological functions, and mechanisms involved in cancer pathogenesis of the tripartite motif (TRIM) gene family. It focuses on TRIM8, a member of the TRIM family proteins, and its roles as both a tumor suppressor and an oncogene. The article summarizes how TRIM8 is involved in breast cancer proliferation through estrogen signaling regulation, and its downregulation in glioma contributes to cell proliferation and affects patient survival. Moreover, the review explores TRIM8's role in the p53 suppressor signaling pathway, the NF-kB pathway, and the JAK-STAT pathway, highlighting its dual role as an oncogene or a tumor suppressor gene in cancer.
Article
Microbiology
Lance R. R. Nigos, Nichollas E. E. Scott, Andrew G. G. Brooks, Malika Ait-Goughoulte, Sarah L. L. Londrigan, Patrick C. Reading, Rubaiyea Farrukee
Summary: Host cell restriction factors are intracellular proteins that can inhibit virus replication. In this study, TRIM16 was investigated as a potential host cell restriction factor. Overexpression of TRIM16 in HEK293T cells resulted in inhibition of multiple viruses, but alternative approaches did not validate these findings.
Article
Biochemistry & Molecular Biology
Zhaoyu Wang, Peng Yu, Yutong Zou, Jieyi Ma, Hui Han, Wei Wei, Chunlong Yang, Siyi Zheng, Siyao Guo, Juan Wang, Lianlian Liu, Shuibin Lin
Summary: This study reveals that METTL1 and WDR4 are overexpressed in osteosarcoma and associated with poor prognosis. Knockdown of METTL1 or WDR4 decreases tRNA m(7)G modification level and impairs osteosarcoma progression. Conversely, overexpression of METTL1/WDR4 promotes osteosarcoma proliferation, migration and invasion capacities. METTL1/WDR4-mediated tRNA m(7)G modification enhances osteosarcoma progression and chemoresistance by altering oncogenic mRNA translation, suggesting that METTL1 inhibition combined with chemotherapy is a promising strategy for treating osteosarcoma patients.
Article
Endocrinology & Metabolism
Yi Ding, MinJae Lee, Yan Gao, Ping Bu, Christian Coarfa, Brian Miles, Arun Sreekumar, Chad J. Creighton, Gustavo Ayala
Summary: The study highlights the crucial role of neuropeptide Y (NPY) nerves in the progression of prostate cancer (PCa) and suggests that targeting the NPY neural microenvironment may be a promising therapeutic approach. Inhibition of NPY has been shown to increase cancer apoptosis, decrease motility, and induce metabolic pathway changes. Furthermore, NPY nerves have been implicated in radiation therapy resistance and could potentially regulate multiple oncogenic mechanisms in PCa.
Article
Oncology
Cam-Thu Ha, Chih-Yuan Cheng, Ming-Yi Zheng, Tang-Hui Hsu, Chia-Cheng Miao, Chang-Jung Lee, Horng-Dar Wang, Shien-Tung Pan, Yu-Ting Chou
Summary: The ID4-BDNF signaling pathway plays a crucial role in colorectal cancer, affecting tumor growth, migration, and chemosensitivity.
Review
Biochemistry & Molecular Biology
Sharon E. Murphy
Summary: Nicotine is the main addictive component of tobacco, and its metabolism plays a crucial role in smoking behavior and dose. Understanding nicotine biotransformation, particularly the role of enzymes like cytochrome P450 2A6, can help identify individuals at higher risk for tobacco-related diseases such as lung cancer.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Immunology
Zheng Jin, Zhenhua Zhu
Summary: Pattern recognition receptors (PRRs) are recognition molecules mainly expressed on innate immune cells, recognizing pathogen-associated molecular patterns (PAMPs) to induce cytokine production and exacerbate immune-related diseases. TRIM proteins, highly conserved in structure and often containing a RING domain, play important roles in processes like ubiquitination and are involved in various immune-related functions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samikshan Dutta, Navatha Shree Polavaram, Ridwan Islam, Sreyashi Bhattacharya, Sanika Bodas, Thomas Mayr, Sohini Roy, Sophie Alvarez Y. Albala, Marieta Toma, Anza Darehshouri, Angelika Borkowetz, Stefanie Conrad, Susanne Fuessel, Manfred Wirth, Gustavo B. Baretton, Lorenz C. Hofbauer, Paramita Ghosh, Kenneth J. Pienta, David L. Klinkebiel, Surinder K. Batra, Michael H. Muders, Kaustubh Datta
Summary: This study identified a novel AR transcriptional complex involving NRP2, which promotes the expression of CRPC-specific genes. Inhibition of NRP2 was found to enhance the sensitivity of CRPC cells to anti-AR therapies.
Review
Biochemistry & Molecular Biology
Carlotta Liberale, Davide Soloperto, Alessandro Marchioni, Daniele Monzani, Luca Sacchetto
Summary: Laryngeal cancer, a common tumor in the upper aero-digestive tract, has garnered significant interest in understanding its biological mechanisms. The development of laryngeal squamous cell carcinoma (LSCC) follows a multistep process, with various risk factors involved. Genetic alterations, including inactivation of tumor suppressor genes and activation of proto-oncogenes through mechanisms like mutations and amplification, play a crucial role. Additionally, epigenetic modifications driven by miRNAs have been shown to contribute to LSCC development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wenbin Liu, Yang Deng, Zishuai Li, Yifan Chen, Xiaoqiong Zhu, Xiaojie Tan, Guangwen Cao
Summary: Chronic inflammation plays a key role in cancer development by interacting with genetic predispositions, environmental exposures, and inflammation-related carcinogenic factors. Interventions that reduce inflammation levels, such as exercising and anti-inflammatory medications, can lower the risk of cancer occurrence and recurrence. The Cancer Evo-Dev theory helps understand how inflammation promotes cancer development and provides a foundation for effective prophylaxis and targeted therapy of various cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Angeliki-Ioanna Giannopoulou, Charalampos Xanthopoulos, Christina Piperi, Efterpi Kostareli
Summary: TRIM proteins play a crucial role in glioma progression and may become potential targets for future treatment. Gliomas are highly heterogeneous and invasive tumors, requiring a better understanding of their molecular mechanisms. TRIM proteins may serve as prognostic biomarkers and therapeutic targets, providing more promising tools for the diagnosis and treatment of gliomas.
Review
Biochemistry & Molecular Biology
Juan Liu, Cen Zhang, Xue Wang, Wenwei Hu, Zhaohui Feng
Summary: p53 is a key tumor suppressor and is involved in various physiological and pathological processes. TRIM proteins, characterized by specific domains, play important roles in regulating fundamental biological processes. There is a cross-talk between p53 and TRIM proteins, impacting cellular processes, cancer, and other diseases.
Article
Cell Biology
Zeng Zhenhao, Chen Ru, Cheng Xiaofeng, Yang Heng, Wang Gongxian
Summary: This study reveals that circMAML3 is highly expressed in prostate cancer and promotes tumor progression by upregulating the expression of MAPK8IP2. These findings suggest that circMAML3 may serve as a potential biomarker for the diagnosis, treatment, and prognosis of prostate cancer.
CELL DEATH DISCOVERY
(2023)
