The role of TRIM proteins in PRR signaling pathways and immune-related diseases

Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis

(2020) Xue Bai et al.   EXPERIMENTAL CELL RESEARCH

TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages

(2020) Zheng Jin et al.   Frontiers in Immunology

Pattern Recognition Receptor Ligands as an Emerging Therapeutic Agent for Latent HIV-1 Infection

(2020) Shokichi Takahama et al.   Frontiers in Cellular and Infection Microbiology

TRIM21 Aggravates Herpes Simplex Virus Epithelial Keratitis by Attenuating STING-IRF3-Mediated Type I Interferon Signaling

(2020) Tianchang Tan et al.   Frontiers in Microbiology

Promising targets based on pattern recognition receptors for cancer immunotherapy

(2020) Ling Bai et al.   PHARMACOLOGICAL RESEARCH

Detection of Viral Infections by Innate Immunity

(2020) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

The innate immune system and cell death in autoinflammatory and autoimmune disease

(2020) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

(2020) V. Kumar   INTERNATIONAL IMMUNOPHARMACOLOGY

Tripartite motif proteins: an emerging antiviral protein family

(2019) Girish Patil et al.   Future Virology

The interplay between viruses and TRIM family proteins

(2019) Ramisha Khan et al.   REVIEWS IN MEDICAL VIROLOGY

TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4

(2019) Qian Liang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TRIM69 inhibits cataractogenesis by negatively regulating p53

(2019) Xianfang Rong et al.   Redox Biology

Gout

(2019) Nicola Dalbeth et al.   Nature Reviews Disease Primers

TRIM59: A membrane protein expressed on Bacillus Calmette-Guérin-activated macrophages that induces apoptosis of fibrosarcoma cells by direct contact

(2019) Yuan Tian et al.   EXPERIMENTAL CELL RESEARCH

Prognostic significance of TRIM59 for cancer patient survival

(2019) Min Wang et al.   MEDICINE

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

(2019) Ghizlane Maarifi et al.   Science Advances

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation

(2018) Kabsun Kim et al.   BONE

USP7–TRIM27 axis negatively modulates antiviral type I IFN signaling

(2018) Juan Cai et al.   FASEB JOURNAL

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

TRIM29 negatively controls antiviral immune response through targeting STING for degradation

(2018) Qijie Li et al.   Cell Discovery

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

(2018) Senlin Li et al.   Cell Reports

TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and Pancreatic Injury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production

(2018) Hui Liu et al.   Frontiers in Immunology

TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF–TBK1 Interaction

(2017) Wen Ye et al.   JOURNAL OF IMMUNOLOGY

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling

(2017) Peng Tan et al.   MOLECULAR CELL

The tripartite motif-containing protein 3 on the proliferation and cytokine secretion of rheumatoid arthritis fibroblast-like synoviocytes

(2017) Mingjun Wang et al.   Molecular Medicine Reports

BCG Increased Membrane Expression of TRIM59 Through the TLR2/ TLR4/IRF5 Pathway in RAW264.7 Macrophages

(2017) Zheng Jin et al.   PROTEIN AND PEPTIDE LETTERS

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

(2017) Qing Yang et al.   PLoS Pathogens

TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1

(2016) Yunfei Qin et al.   CELL RESEARCH

Inflammatory Disequilibrium in Stroke

(2016) Danica Petrovic-Djergovic et al.   CIRCULATION RESEARCH

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

Autoinflammatory diseases: update on classification diagnosis and management

(2016) Shelly Pathak et al.   JOURNAL OF CLINICAL PATHOLOGY

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

(2016) Xueting Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract

(2016) Junji Xing et al.   NATURE IMMUNOLOGY

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

Signaling via the NFκB system

(2016) Simon Mitchell et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

(2015) Qingliang Zheng et al.   CELL RESEARCH

TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin

(2015) Masanobu Suzuki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF- B Pathways along with TNFR-Associated Factor 6

(2015) T.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms

(2015) Ming-Ming Hu et al.   JOURNAL OF IMMUNOLOGY

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

(2015) Yong Ran et al.   Journal of Molecular Cell Biology

TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

(2015) Yanming Wang et al.   PLoS Pathogens

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

(2015) Peng Wang et al.   PLoS Pathogens

TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-κB activation

(2014) Dhanendra Tomar et al.   CELLULAR SIGNALLING

TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production

(2014) K. Narayan et al.   JOURNAL OF VIROLOGY

TRIM38 inhibits TNF - and IL-1 -triggered NF- B activation by mediating lysosome-dependent degradation of TAB2/3

(2014) M.-M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9

(2014) Mude Shi et al.   Nature Communications

Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA

(2013) B. Yang et al.   JOURNAL OF IMMUNOLOGY

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

TRIM11 Negatively Regulates IFNβ Production and Antiviral Activity by Targeting TBK1

(2013) Younglang Lee et al.   PLoS One

TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation

(2013) Hui Qiu et al.   VIROLOGICA SINICA

TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways

(2012) Takeshi Kondo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation

(2012) Mio Shibata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

TRIM56 Is an Essential Component of the TLR3 Antiviral Signaling Pathway

(2012) Yang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tripartite Motif-Containing Protein 38 Negatively Regulates TLR3/4- and RIG-I-Mediated IFN-  Production and Antiviral Response by Targeting NAP1

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

TRIM Protein-Mediated Regulation of Inflammatory and Innate Immune Signaling and Its Association with Antiretroviral Activity

(2012) P. D. Uchil et al.   JOURNAL OF VIROLOGY

A novel accessory molecule Trim59 involved in cytotoxicity of BCG-activated macrophages

(2012) Xiangfeng Zhao et al.   MOLECULES AND CELLS

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

(2012) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Tyrosine Phosphorylation of the E3 Ubiquitin Ligase TRIM21 Positively Regulates Interaction with IRF3 and Hence TRIM21 Activity

(2012) Kevin B. Stacey et al.   PLoS One

TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members

(2012) Jessica L. Bell et al.   PLoS One

TRIM38 Negatively Regulates TLR3-Mediated IFN-β Signaling by Targeting TRIF for Degradation

(2012) Qinghua Xue et al.   PLoS One

Identification of tripartite motif-containing 22 (TRIM22) as a novel NF-κB activator

(2011) Shanshan Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM40 promotes neddylation of IKK  and is downregulated in gastrointestinal cancers

(2011) K. Noguchi et al.   CARCINOGENESIS

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation

(2011) Luisa M. Napolitano et al.   IUBMB LIFE

Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7

(2011) Q. Liang et al.   JOURNAL OF IMMUNOLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

(2011) Bjørn A. Nexø et al.   PLoS One

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tripartite-motif proteins and innate immune regulation

(2010) Finlay W McNab et al.   CURRENT OPINION IN IMMUNOLOGY

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

(2010) Tetsuo Tsuchida et al.   IMMUNITY

Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: Is it a susceptibility gene?

(2010) Aysun Unal et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

(2010) Miwa Sasai et al.   MOLECULAR IMMUNOLOGY

Downregulation of active IKKβ by Ro52-mediated autophagy

(2010) Motoko Niida et al.   MOLECULAR IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

(2010) K.-i. Arimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-MDA5 and anti-TIF1-γ antibodies have clinical significance for patients with dermatomyositis

(2010) Kei Hoshino et al.   RHEUMATOLOGY

The genetics of autoimmune diseases: a networked perspective

(2009) Sergio E Baranzini   CURRENT OPINION IN IMMUNOLOGY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Ro52-mediated Monoubiquitination of IKK  Down-regulates NF- B Signalling

(2009) K. Wada et al.   JOURNAL OF BIOCHEMISTRY

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Identification of TRIM23 as a Cofactor Involved in the Regulation of NF- B by Human Cytomegalovirus

(2009) E. Poole et al.   JOURNAL OF VIROLOGY

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF- B through its N-terminal fragment

(2008) J. J. Chae et al.   BLOOD

TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation

(2008) Mude Shi et al.   NATURE IMMUNOLOGY

TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

(2008) Pradeep D. Uchil et al.   PLoS Pathogens

Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature

(2008) Teresina Laragione et al.   ARTHRITIS RESEARCH & THERAPY

The role of TLR activation in inflammation

(2007) I Sabroe et al.   JOURNAL OF PATHOLOGY