Effects of metformin on parasitological, pathological changes in the brain and liver and immunological aspects during visceral toxocariasis in mice

Therapy and Prevention for Human Toxocariasis

(2022) Jean-François Magnaval et al.   Microorganisms

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

(2022) Gufang Zhang et al.   Frontiers in Pharmacology

Coenzyme Q10 prevented Trypanosoma brucei rhodesiense-mediated breach of the blood brain barrier, inflammation and organ damage in late stage of Human African Trypanosomiasis

(2022) Lynn Kitwan et al.   Journal of Parasitic Diseases

Role of fibroblast growth factor signaling in hepatic fibrosis

(2021) Tatjana Seitz et al.   LIVER INTERNATIONAL

TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis

(2021) Hongrui Guo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

FGF21 ameliorates hepatic fibrosis by multiple mechanisms

(2021) Fanrui Meng et al.   MOLECULAR BIOLOGY REPORTS

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

(2020) Yetao Xu et al.   Cell Reports

Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model

(2020) Partow Mirzaee Saffari et al.   LIFE SCIENCES

FGF21 regulates hepatic metabolic pathways to improve steatosis and inflammation

(2020) Helle Keinicke et al.   Endocrine Connections

Transforming Growth Factor Beta-Induced Foxo3a Acts as a Profibrotic Mediator in Hepatic Stellate Cells

(2020) Seung Jung Kim et al.   TOXICOLOGICAL SCIENCES

Maltol Mitigates Thioacetamide-induced Liver Fibrosis through TGF-β1-mediated Activation of PI3K/Akt Signaling Pathway

(2019) Xiao-jie Mi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice

(2019) Weiguo Fan et al.   GASTROENTEROLOGY

Immune response to chronic Toxocara canis infection in a mice model

(2019) Rocío Alejandra Ruiz‐Manzano et al.   PARASITE IMMUNOLOGY

Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis

(2019) Patrick Waindok et al.   PLoS Neglected Tropical Diseases

Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway

(2018) Li Tao et al.   BRAIN RESEARCH BULLETIN

Human toxocariasis

(2018) Guangxu Ma et al.   LANCET INFECTIOUS DISEASES

Elevation of MMP-9 Levels Promotes Epileptogenesis After Traumatic Brain Injury

(2018) Barbara Pijet et al.   MOLECULAR NEUROBIOLOGY

Toxocarosis in children: poor hygiene habits and contact with dogs is related to longer treatment

(2018) Anna Kroten et al.   PARASITOLOGY RESEARCH

High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma

(2018) Haitao Niu et al.   PeerJ

Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion

(2018) Mana Miyakoda et al.   Frontiers in Immunology

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation

(2017) Di Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess Aβ accumulation in the hippocampus of mice with persistent cerebral toxocariasis

(2017) Chia-Mei Chou et al.   Parasites & Vectors

Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K/Akt signaling pathway

(2017) Guangming Tang et al.   Oncotarget

Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis

(2017) Julia A. Loos et al.   PLoS Neglected Tropical Diseases

Neurotoxocariasis: a systematic literature review

(2016) S. Deshayes et al.   INFECTION

Modulation of IL-12 and IFNγ by probiotic supplementation promotes protection against Toxocara canis infection in mice

(2016) L. F. d. C. de Avila et al.   PARASITE IMMUNOLOGY

Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection

(2016) Ahmad A. Othman et al.   PARASITOLOGY INTERNATIONAL

Prevalence and risk factors for patent Toxocara infections in cats and cat owners’ attitude towards deworming

(2016) R. Nijsse et al.   PARASITOLOGY RESEARCH

Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways

(2016) Pengfei Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Presence of Toxocara spp. eggs in children’s recreation areas with varying degrees of access for animals

(2015) Joanna Błaszkowska et al.   ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a

(2015) Latt Latt Aung et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunopathological Changes in the Brain of Immunosuppressed Mice Experimentally Infected with <I>Toxocara canis</I>

(2015) Mohamed M. Eid et al.   KOREAN JOURNAL OF PARASITOLOGY

Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts

(2015) Jiamei Lu et al.   LIFE SCIENCES

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

(2015) L. Probert   NEUROSCIENCE

New insights into the immunopathology of early Toxocara canis infection in mice

(2015) Nathália M. Resende et al.   Parasites & Vectors

Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway

(2015) Li Li et al.   Oncotarget

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction

(2014) Juyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Resveratrol Attenuates Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NF-κB-Dependent Inflammatory/MMP-9 Pathway

(2013) An-Wen Shao et al.   CNS Neuroscience & Therapeutics

MMP-9 Inhibition: a Therapeutic Strategy in Ischemic Stroke

(2013) Mayank Chaturvedi et al.   MOLECULAR NEUROBIOLOGY

Signal Transducer and Activator of Transcription Factor 6 Signaling Contributes to Control Host Lung Pathology but Favors Susceptibility againstToxocara canisInfection

(2013) Berenice Faz-López et al.   Biomed Research International

Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial

(2012) Alireza Esteghamati et al.   CLINICAL NUTRITION

Metformin Stimulates FGF21 Expression in Primary Hepatocytes

(2012) Eva B. Nygaard et al.   Experimental Diabetes Research

The significance of cerebral toxocariasis: a model system for exploring the link between brain involvement, behaviour and the immune response

(2012) C. V. Holland et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Toxocara canis: Molecular basis of immune recognition and evasion

(2012) Rick M. Maizels   VETERINARY PARASITOLOGY

Emerging Zoonoses in the Southern United States: Toxocariasis, Bovine Tuberculosis and Southern Tick-Associated Rash Illness

(2010) Rachel M. Clinton et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

(2010) Xinguo Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vivo evaluation of albendazole microspheres for the treatment of Toxocara canis larva migrans

(2010) María G. Barrera et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Kinetics of Foxp3-expressing regulatory cells in experimental Toxocara canis infection

(2010) Ahmad A. Othman et al.   EXPERIMENTAL PARASITOLOGY

Biochemical and immunopathological changes in experimental neurotoxocariasis

(2010) Ahmad A. Othman et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Effects of methylene blue in reducing cholestatic oxidative stress and hepatic damage after bile-duct ligation in rats

(2009) Burhan Aksu et al.   ACTA HISTOCHEMICA

Immunohistochemical analysis of MMP-9, MMP-2 and TIMP-1, TIMP-2 expression in the central nervous system following infection with viral and bacterial meningitis.

(2009) Artur Sulik et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Anthelmintic activity of benzimidazole derivatives against Toxocara canis second-stage larvae and Hymenolepis nana adults

(2008) Adrián Márquez-Navarro et al.   ACTA TROPICA

Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canisin mice

(2008) Chien-Wei Liao et al.   BMC INFECTIOUS DISEASES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Selenium supplementation enhances the protective response toToxocara canislarvae in mice

(2008) B. PILARCZYK et al.   PARASITE IMMUNOLOGY

Anti-eosinophilic effect of Lafoensia pacari in toxocariasis

(2007) A.P. Rogerio et al.   PHYTOMEDICINE

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY