DISC1 causes associative memory and neurodevelopmental defects in fruit flies

Fruit Flies in Biomedical Research

(2015) M. F. Wangler et al.   GENETICS

Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease

(2015) Masanori Itakura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupted-in-schizophrenia 1 (DISC1) Regulates Dysbindin Function by Enhancing Its Stability

(2015) Seol-Ae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment

(2015) Alaura Androschuk et al.   Frontiers in Psychiatry

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases

(2014) Wu-Lin Charng et al.   CURRENT OPINION IN NEUROBIOLOGY

Schizophrenia: from dopaminergic to glutamatergic interventions

(2014) Marc Laruelle   CURRENT OPINION IN PHARMACOLOGY

Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders

(2014) Baohu Ji et al.   HUMAN MOLECULAR GENETICS

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

(2014) D J Porteous et al.   MOLECULAR PSYCHIATRY

Drosophila models of early onset cognitive disorders and their clinical applications

(2014) Monique van der Voet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Discovery of Brainwide Neural-Behavioral Maps via Multiscale Unsupervised Structure Learning

(2014) J. T. Vogelstein et al.   SCIENCE

Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models

(2014) Caleb A. Doll et al.   Frontiers in Cellular Neuroscience

Induction of Associative Olfactory Memory by Targeted Activation of Single Olfactory Neurons in Drosophila Larvae

(2014) Takato Honda et al.   Scientific Reports

Maggot learning and Synapsin function

(2013) S. Diegelmann et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Questions about DISC1 as a genetic risk factor for schizophrenia

(2013) P F Sullivan   MOLECULAR PSYCHIATRY

DISC1

(2013) Soumya Narayan et al.   NEUROSCIENTIST

Development and plasticity of the Drosophila larval neuromuscular junction

(2013) Kaushiki P. Menon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

DISC1 as a therapeutic target for mental illnesses

(2012) Takatoshi Hikida et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

(2012) Jennifer E. Eykelenboom et al.   HUMAN MOLECULAR GENETICS

Spectraplakins Promote Microtubule-Mediated Axonal Growth by Functioning As Structural Microtubule-Associated Proteins and EB1-Dependent +TIPs (Tip Interacting Proteins)

(2012) J. Alves-Silva et al.   JOURNAL OF NEUROSCIENCE

The RhoGEF Trio Functions in Sculpting Class Specific Dendrite Morphogenesis in Drosophila Sensory Neurons

(2012) Srividya Chandramouli Iyer et al.   PLoS One

Microtubules and Lis-1/NudE/Dynein Regulate Invasive Cell-on-Cell Migration in Drosophila

(2012) Nachen Yang et al.   PLoS One

Aggregated proteins in schizophrenia and other chronic mental diseases

(2012) Carsten Korth   Prion

Exorcising the Exocyst Complex

(2012) Margaret R. Heider et al.   TRAFFIC

Wnt Signaling in Neuromuscular Junction Development

(2012) K. Koles et al.   Cold Spring Harbor Perspectives in Biology

Convergence of Two Independent Mental Disease Genes on the Protein Level: Recruitment of Dysbindin to Cell-Invasive Disrupted-In-Schizophrenia 1 Aggresomes

(2011) Philipp Ottis et al.   BIOLOGICAL PSYCHIATRY

Drosophila strategies to study psychiatric disorders

(2011) Bart van Alphen et al.   BRAIN RESEARCH BULLETIN

A behavior-based circuit model of how outcome expectations organize learned behavior in larval Drosophila

(2011) M. Schleyer et al.   LEARNING & MEMORY

Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53

(2011) X Ma et al.   MOLECULAR PSYCHIATRY

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

Traces of Drosophila Memory

(2011) Ronald L. Davis   NEURON

Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila

(2011) L. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DISC1 at 10: connecting psychiatric genetics and neuroscience

(2011) David J. Porteous et al.   TRENDS IN MOLECULAR MEDICINE

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Insoluble DISC1–Boymaw fusion proteins

(2010) X Zhou et al.   MOLECULAR PSYCHIATRY

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

(2010) Q Wang et al.   MOLECULAR PSYCHIATRY

Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation

(2010) H Ito et al.   MOLECULAR PSYCHIATRY

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future

(2010) Hugo J. Bellen et al.   NATURE REVIEWS NEUROSCIENCE

Oligomer Assembly of the C-Terminal DISC1 Domain (640−854) Is Controlled by Self-Association Motifs and Disease-Associated Polymorphism S704C

(2009) S. Rutger Leliveld et al.   BIOCHEMISTRY

Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death

(2009) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of the Drosophila NudE protein in kinetochore function and centrosome migration

(2009) A. Wainman et al.   JOURNAL OF CELL SCIENCE

Distinctive Neuronal Networks and Biochemical Pathways for Appetitive and Aversive Memory in Drosophila Larvae

(2009) K. Honjo et al.   JOURNAL OF NEUROSCIENCE

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth

(2009) C A Ghiani et al.   MOLECULAR PSYCHIATRY

Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants

(2009) Derek Lessing et al.   NATURE REVIEWS GENETICS

The Schizophrenia Susceptibility Gene dysbindin Controls Synaptic Homeostasis

(2009) D. K. Dickman et al.   SCIENCE

Insolubility of Disrupted-in-Schizophrenia 1 Disrupts Oligomer-Dependent Interactions with Nuclear Distribution Element 1 and Is Associated with Sporadic Mental Disease

(2008) S. R. Leliveld et al.   JOURNAL OF NEUROSCIENCE

The fruitfly Drosophila melanogaster: a promising model to explore molecular psychiatry

(2008) N Sawamura et al.   MOLECULAR PSYCHIATRY