Article
Entomology
Md Zeeshan Ali, Anushree Anushree, Anwar L. Bilgrami, Aarif Ahsan, Mohammad Shamsul Ola, Rizwanul Haque, Jawaid Ahsan
Summary: Phenylacetaldehyde (PAH), an aromatic odorant, serves as an important food and courtship cue for adult fruit flies. Our study found that larvae are attracted to PAH in a dose-dependent manner and can be trained with PAH as a marker for positive and negative reinforcement. Unlike adult flies, larvae primarily sense PAH through odorant receptors. This study provides valuable insights into how larvae perceive and process PAH odorant at the neural level.
JOURNAL OF INSECT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Rodi Topci, Mihai Alevra, Erik H. U. Rauf, Danielle de Jong-Bolm
Summary: This study investigated the activity of olfactory receptor neurons and their axon terminals in olfactory glomeruli using electrophysiological recordings and rapid 4D calcium imaging. While individual olfactory receptor neurons show diversity in their responses to the same odor stimulus at the soma level, the presynaptic calcium activity in the glomerulus is homogeneous. It was also found that by applying trains of olfactory stimuli with varying amino acid concentrations, it is possible to induce spatio-temporal presynaptic response inhomogeneities and visually distinguish different axon subgroups within the glomerulus.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yingwei Zheng, Sijue Tao, Yue Liu, Jingjing Liu, Liping Sun, Yawen Zheng, Yu Tian, Peng Su, Xutao Zhu, Fuqiang Xu
Summary: This study reveals the projections of basal forebrain cholinergic neurons and their role in olfactory associative learning. The HMSc-dHIP cholinergic circuit plays a crucial role in regulating olfactory associative learning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aseel El Hajj, Ameziane Herzine, Gaetano Calcagno, Frederic Desor, Fathia Djelti, Vincent Bombail, Isabelle Denis, Thierry Oster, Catherine Malaplate, Maxime Vigier, Sandra Kaminski, Lynn Pauron, Catherine Corbier, Frances T. Yen, Marie-Claire Lanhers, Thomas Claudepierre
Summary: Perturbations in cholesterol metabolism are linked to neurodegenerative diseases. The interaction between glial cells and neurons is essential for regulating brain cholesterol trafficking. The lipolysis-stimulated lipoprotein receptor (LSR) plays a crucial role in maintaining brain cholesterol homeostasis. Deficiency of astroglial LSR may result in cognitive defects and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Nada Y. Abdelrahman, Eleni Vasilaki, Andrew C. Lin
Summary: The study investigates compensatory variability in the population of neurons within the Drosophila mushroom body and demonstrates its computational benefits for associative memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Katrin Vogt, David M. Zimmerman, Matthias Schlichting, Luis Hernandez-Nunez, Shanshan Qin, Karen Malacon, Michael Rosbash, Cengiz Pehlevan, Albert Cardona, Aravinthan D. T. Samuel
Summary: Animals exhibit different behavioral responses to the same sensory cue depending on their internal state at a given moment. Hunger flexibly alters neural processing in the antennal lobe, modulating two output pathways required for opposing behavioral responses. This state-dependent circuit dynamics in an early sensory processing center demonstrate how flexible behaviors can arise.
Article
Multidisciplinary Sciences
Kevin W. Zhu, Shawn D. Burton, Maira H. Nagai, Justin D. Silverman, Claire A. de March, Matt Wachowiak, Hiroaki Matsunami
Summary: This study utilized targeted spatial transcriptomics to map the distribution of olfactory receptors in the murine olfactory bulb and generated a 3D model. The findings revealed a relationship between receptors and odorants, providing significant insights into olfaction.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Istvan Taisz, Erika Dona, Daniel Munch, Shanice N. Bailey, Billy J. Morris, Kimberly I. Meechan, Katie M. Stevens, Irene Varela-Martinez, Marina Gkantia, Philipp Schlegel, Carlos Ribeiro, Gregory S. X. E. Jefferis, Dana S. Galili
Summary: In Drosophila, a specific olfactory channel processes male pheromones, promoting female courtship and repelling males. The processing streams extract qualitative and positional information, with sensory neurons and projection neurons encoding concentration differences and angular positions of males. The third circuit layer consists of 47 cell types with diverse input-output connectivity, enabling behavioral responses in specific ethological contexts through multisensory integration.
Article
Neurosciences
Yi Zhang, Yihao Zhang, Cong Shen, Shun Hao, Wenlan Duan, Li Liu, Hongying Wei
Summary: This study investigates the effects of ionizing radiation on neurotransmitter-evoked responses in Drosophila larvae. It is found that ionizing radiation alters the responses to neurotransmitters, indicating that synapses are vulnerable targets of radiation. These findings provide new insights for preventive therapeutic interventions to reduce neurological deficits after radiation therapy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biology
Nicolas Pirez, Martin Klappenbach, Fernando F. Locatelli
Summary: Insects rely on their sense of smell to perceive informative odors for reproduction, but these odors may be mixed with environmental odors that can disrupt their perception. The first two layers of the olfactory system play a critical role in optimizing the representation of the odors of interest, and experiencedependent changes affect these two layers.
CURRENT OPINION IN INSECT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tongchao Li, Tian-Ming Fu, Kenneth Kin Lam Wong, Hongjie Li, Qijing Xie, David J. Luginbuhl, Mark J. Wagner, Eric Betzig, Liqun Luo
Summary: The study investigates the dynamic cellular processes by which olfactory receptor neurons target axons to specific glomeruli in the olfactory circuit of Drosophila. Through time-lapse imaging and fast imaging techniques, the researchers identified the mechanisms involved in ipsilateral targeting and revealed the dynamics of axon branching upon approaching the target. These observations provide insights into the cellular basis of wiring specificity establishment.
Article
Biology
Colleen N. McLaughlin, Maria Brbic, Qijing Xie, Tongchao Li, Felix Horns, Sai Saroja Kolluru, Justus M. Kebschull, David Vacek, Anthony Xie, Jiefu Li, Robert C. Jones, Jure Leskovec, Stephen R. Quake, Liqun Luo, Hongjie Li
Summary: By analyzing single-cell transcriptomes of Drosophila sensory neurons, researchers found that different neuron types maintain expression of the same olfactory receptors across development, and cell-type-specific transcriptomes are associated with axon trajectory choices in development and sensory modality in adults. Additionally, stage-specific genes were identified that could regulate the wiring and sensory responses of distinct neuron types.
Article
Biology
Maarten Wissink, Volker Nehring
Summary: The study found that in appetitive olfactory learning in ants, octopamine signaling is crucial for learning to expect reward-associated odors, while dopamine may play a role in long-term memory consolidation.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alina Vulpe, Hyong S. Kim, Sydney Ballou, Shiuan-Tze Wu, Veit Grabe, Cesar Nava Gonzales, Tiffany Liang, Silke Sachse, James M. Jeanne, Chih-Ying Su, Karen Menuz
Summary: Ammonia attracts various insects, including hematophagous ones and fruit flies, but most insect genomes lack the gene responsible for ammonia sensitivity.
Review
Biochemistry & Molecular Biology
Aelon Rahmani, Yee Lian Chew
Summary: This review highlights the advances in studying learning through the nematode Caenorhabditis elegans, which has a compact nervous system and genetic tractability. By targeting distinct sensory modalities, learning and memory can be studied, along with understanding key molecular and cellular pathways.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Shin Nakane, Jun Tomita, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Seiya Mizuno, Shinichi Miyazaki, Linzi Connor, Vivek Kumar, Ikuo Miura, Tomohiro Suzuki, Atsushi Watanabe, Manabu Abe, Fumihiro Sugiyama, Satoru Takahashi, Kenji Sakimura, Yu Hayashi, Qinghua Liu, Kazuhiko Kume, Shigeharu Wakana, Joseph S. Takahashi, Masashi Yanagisawa
Article
Behavioral Sciences
Takato Honda, Chi-Yu Lee, Ken Honjo, Katsuo Furukubo-Tokunaga
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2016)
Article
Clinical Neurology
Haruna Komiya, Chika Miyoshi, Kanako Iwasaki, Noriko Hotta-Hirashima, Aya Ikkyu, Satomi Kanno, Takato Honda, Masahiko Gosho, Hiromi Hamada, Toyomi Satoh, Akiyoshi Fukamizu, Hiromasa Funato, Masashi Yanagisawa
Article
Clinical Neurology
Haruna Komiya, Chika Miyoshi, Kanako Iwasaki, Noriko Hotta-Hirashima, Aya Ikkyu, Satomi Kanno, Takato Honda, Masahiko Gosho, Hiromi Hamada, Toyomi Satoh, Akiyoshi Fukamizu, Hiromasa Funato, Masashi Yanagisawa
Article
Multidisciplinary Sciences
Takato Honda, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Mohammad Sarowar Hossain, Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Makito Sato, Aya Ikkyu, Satomi Kanno, Noriko Hotta, Miyo Kakizaki, Takato Honda, Staci J. Kim, Haruna Komiya, Ikuo Miura, Tomohiro Suzuki, Kimio Kobayashi, Hideki Kaneda, Vivek Kumar, Joseph S. Takahashi, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
SCIENTIFIC REPORTS
(2016)
Article
Neurosciences
Shinnosuke Yasugaki, Chih-Yao Liu, Mitsuaki Kashiwagi, Mika Kanuka, Takato Honda, Shingo Miyata, Masashi Yanagisawa, Yu Hayashi
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Takato Honda, Jinhwan Choi, Fuyuki Asano, Seiya Mizuno, Satoru Takahashi, Masashi Yanagisawa, Hiromasa Funato
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Takato Honda, Yohko Takata, Yoan Cherasse, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa, Michael Lazarus, Yo Oishi
Review
Neurosciences
Takato Honda
Summary: Fruit flies are considered an excellent model in behavioral neuroscience due to their simple neuroanatomical architecture and the availability of various genetic methods. Advanced techniques such as optogenetics and thermogenetics can be used to associate specific neural populations with behavioral outputs, providing insights into the functional connections between neural circuits and behaviors.
Article
Psychiatry
Himani Pandey, Katia Bourahmoune, Takato Honda, Ken Honjo, Kazuki Kurita, Tomohito Sato, Akira Sawa, Katsuo Furukubo-Tokunaga