Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia

Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice

(2022) Biying Zhu et al.   Science Translational Medicine

A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome

(2022) Héléna Boutzen et al.   LEUKEMIA

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

(2021) Eliza Yankova et al.   NATURE

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

(2020) Yue Sheng et al.   Nature Communications

Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling

(2020) Snahlata Singh et al.   NATURE CELL BIOLOGY

Roles of IFN-γ in tumor progression and regression: a review

(2020) Dragica Jorgovanovic et al.   Biomarker Research

Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

(2020) Shruti Bhatt et al.   CANCER CELL

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

(2019) Peter van Galen et al.   CELL

BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment

(2019) Sujan Piya et al.   JOURNAL OF CLINICAL INVESTIGATION

TEMPORARY REMOVAL: IFN-γ: A cytokine at the right time, is in the right place

(2019) J. Daniel Burke et al.   SEMINARS IN IMMUNOLOGY

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

(2019) Xinyue Chen et al.   Nature Communications

IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling

(2018) Yi Gao et al.   INTERNATIONAL JOURNAL OF CANCER

Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

(2018) Bin Guo et al.   NATURE MEDICINE

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation

(2018) Sun-Mi Park et al.   Cell Stem Cell

The Interferon-Gamma Paradox in Cancer

(2018) M. Raza Zaidi   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

The untold story of IFN-γ in cancer biology

(2016) M. Alper Kursunel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interferon-γ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells

(2016) Kavin Fatehchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase CK2 regulates AKT, NF-κB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia

(2016) L Quotti Tubi et al.   LEUKEMIA

Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia

(2016) S Goyama et al.   ONCOGENE

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

(2015) Stéphane Prost et al.   NATURE

Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation

(2015) Fuad Bahram et al.   Oncotarget

Interferon-γ-Induced Necrosis: An Antitumor Biotherapeutic Perspective

(2013) Siddharth Balachandran et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

The Two Faces of Interferon-  in Cancer

(2011) M. R. Zaidi et al.   CLINICAL CANCER RESEARCH

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

(2011) M. Raza Zaidi et al.   NATURE

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Clinical Use of Interferon-γ

(2009) Catriona H.T. Miller et al.   Annals of the New York Academy of Sciences