A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome

A clinical laboratory–developed LSC17 stemness score assay for rapid risk assessment of patients with acute myeloid leukemia

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Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

(2020) Stephanie M. Dobson et al.   Cancer Discovery

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies

(2020) Mark P. Chao et al.   Frontiers in Oncology

Non-Coding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies

(2020) Kailong Li et al.   Cancer Discovery

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

(2020) Courtney L. Jones et al.   Cell Stem Cell

Acute Myeloid Leukemia Stem Cells: The Challenges of Phenotypic Heterogeneity

(2020) Marlon Arnone et al.   Cancers

The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization

(2020) Naoya Takayama et al.   Cell Stem Cell

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

(2019) Peter van Galen et al.   CELL

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency

(2019) Kerstin B. Kaufmann et al.   BLOOD

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

(2019) Anna M. Paczulla et al.   NATURE

Identifying clusters of cis-regulatory elements underpinning TAD structures and lineage-specific regulatory networks

(2019) Seyed Ali Madani Tonekaboni et al.   GENOME RESEARCH

Trial in Progress: Feasibility and Validation Study of the LSC17 Score in Acute Myeloid Leukemia Patients

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Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia

(2018) Isabelle Laverdière et al.   Blood Cancer Journal

The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia

(2018) Nicolas Duployez et al.   LEUKEMIA

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Subtype-specific regulatory network rewiring in acute myeloid leukemia

(2018) Salam A. Assi et al.   NATURE GENETICS

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia

(2018) Peter van Galen et al.   Cell Reports

Tracing the origins of relapse in acute myeloid leukaemia to stem cells

(2017) Liran I. Shlush et al.   NATURE

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

(2016) Eric R. Lechman et al.   CANCER CELL

A 17-gene stemness score for rapid determination of risk in acute leukaemia

(2016) Stanley W. K. Ng et al.   NATURE

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

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Role of non-coding sequence variants in cancer

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Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

(2015) Namyoung Jung et al.   Nature Communications

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Identification of small molecules that support human leukemia stem cell activity ex vivo

(2014) Caroline Pabst et al.   NATURE METHODS

Defining functional DNA elements in the human genome

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Genomic Landscapes and Clonality of De Novo AML

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

(2009) Liqing Jin et al.   Cell Stem Cell

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

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