Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 953, Issue -, Pages 20-29Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2014.01.047
Keywords
Honokiol; Metabolite; Feces; UHPLC/Q-TOF-MS; Stable isotope labeling; Dimer
Funding
- National Key Programs of China during the 12th Five-Year Plan Period [2012ZX09103101-066]
- National Natural Science Foundation of China [81071251]
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As fecal excretion is one of important routes of elimination of drugs and their metabolites, it is indispensable to investigate the metabolites in feces for more comprehensive information on biotransformation in vivo. In this study, a sensitive and reliable approach based on ultra-performance liquid chromatography/quadrupole-time-of-flight-mass spectrometry (UHPLC-Q-TOF-MS) was applied to characterize the metabolic profile of honoldol in rat feces after the administration of an equimolar mixture of honoldol and [C-13(6)]-labeled honokiol. Totally 42 metabolites were discovered and tentatively identified in rat feces samples, 26 metabolites were first reported, including two novel classes of metabolites, methylated and dimeric metabolites of honokiol. Moreover, this study provided basic comparative data on the metabolites in rat plasma, feces and urine, which gave better understanding of the metabolic fate of honokiol in vivo. (C) 2014 Elsevier B.V. All rights reserved.
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