BTD: A TRPC5 activator ameliorates mechanical allodynia in diabetic peripheral neuropathic rats by modulating TRPC5-CAMKII-ERK pathway

Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain

(2023) Niina Jalava et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3-aminobenzamide protects against colitis associated diabetes mellitus in male BALB/c mice: Role of PARP-1, NLRP3, SIRT-1, AMPK

(2023) Shivani Singla et al.   BIOCHIMIE

Analysis of the Effect of the TRPC4/TRPC5 Blocker, ML204, in Sucrose-Induced Metabolic Imbalance

(2023) Mizael C. Araújo et al.   Pharmaceuticals

Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia

(2022) Xiao-fen He et al.   Purinergic Signalling

Protein Kinase C regulation of ion channels: the involvement of PIP2

(2022) Kirin D. Gada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Development of Mechanical Allodynia in Diabetic Rats Revealed by Single-Cell RNA-Seq

(2022) Han Zhou et al.   Frontiers in Molecular Neuroscience

Caffeic Acid Phenethyl Ester (CAPE) Attenuates Paclitaxel-Induced Peripheral Neuropathy: A Mechanistic Study

(2022) Shyam Sunder Sharma et al.   CURRENT NEUROVASCULAR RESEARCH

PIP2 regulation of TRPC5 channel activation and desensitization

(2021) Mehek Ningoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice

(2021) Katelyn E. Sadler et al.   Science Translational Medicine

Spinal Cord Stimulation Attenuates Mechanical Allodynia and Increases Central Resolvin D1 Levels in Rats With Spared Nerve Injury

(2021) Xueshu Tao et al.   Frontiers in Physiology

Painful diabetic peripheral neuropathy: Role of oxidative stress and central sensitisation

(2021) Di Ye et al.   DIABETIC MEDICINE

Pharmacological inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study

(2020) Pavan Thapak et al.   CURRENT NEUROVASCULAR RESEARCH

Silencing of spinal Trpv1 attenuates neuropathic pain in rats by inhibiting CAMKII expression and ERK2 phosphorylation

(2019) Shao-Hui Guo et al.   Scientific Reports

Painful and Painless Diabetic Neuropathies: What Is the Difference?

(2019) Pallai Shillo et al.   Current Diabetes Reports

Pharmacological Inhibition of Porcupine, Disheveled and β-catenin in Wnt Signaling Pathway Ameliorates Diabetic Peripheral Neuropathy in Rats

(2019) Kahkashan Resham et al.   JOURNAL OF PAIN

Redox TRPs in diabetes and diabetic complications: Mechanisms and pharmacological modulation

(2019) Pratik Adhya et al.   PHARMACOLOGICAL RESEARCH

Diabetic polyneuropathy and pain, prevalence, and patient characteristics

(2019) Sandra Sif Gylfadottir et al.   PAIN

Pharmacological interventions targeting Wnt/β-catenin signaling pathway attenuate paclitaxel-induced peripheral neuropathy

(2019) Kahkashan Resham et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord

(2018) Ting-Ting Zhang et al.   Journal of Neuroinflammation

The role of CaMKII in Neuropathic Pain and Fear Memory in Chronic Constriction Injury in Rats

(2018) Yue Qian et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Contribution of Zinc-Dependent Delayed Calcium Influx via TRPC5 in Oxidative Neuronal Death and its Prevention by Novel TRPC Antagonist

(2018) Sang Eun Park et al.   MOLECULAR NEUROBIOLOGY

Pretreatment-Etidronate Alleviates CoCl2 Induced-SH-SY5Y Cell Apoptosis via Decreased HIF-1α and TRPC5 Channel Proteins

(2018) Kai Li et al.   NEUROCHEMICAL RESEARCH

Hyperpolarization-activated cyclic nucleotide–gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy

(2017) Christoforos Tsantoulas et al.   Science Translational Medicine

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation

(2016) Khadija M Alawi et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease

(2015) Chansik Hong et al.   BRAIN

Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy

(2015) Shivsharan B. Kharatmal et al.   NEUROPHARMACOLOGY

Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury

(2012) Eric D. Crown et al.   PAIN

A brief comparison of the pathophysiology of inflammatory versus neuropathic pain

(2011) Qinghao Xu et al.   Current Opinion in Anesthesiology

Preservation of Acute Pain and Efferent Functions Following Intrathecal Resiniferatoxin-Induced Analgesia in Rats

(2011) Mahendra Bishnoi et al.   JOURNAL OF PAIN

Determinants of TRPV4 Activity following Selective Activation by Small Molecule Agonist GSK1016790A

(2011) Min Jin et al.   PLoS One

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy

(2010) Ashutosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Concurrent targeting of nitrosative stress–PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy

(2009) Geeta Negi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS