Identifying risk loci for FTD and shared genetic component with ALS: a large-scale multi-trait association analysis

Genetic correlation and gene-based pleiotropy analysis for four major neurodegenerative diseases with summary statistics

(2023) Jiahao Qiao et al.   NEUROBIOLOGY OF AGING

Genetic risk factor clustering within and across neurodegenerative diseases

(2023) Mathew J Koretsky et al.   BRAIN

Advances and controversies in frontotemporal dementia: diagnosis, biomarkers, and therapeutic considerations

(2022) Bradley F Boeve et al.   LANCET NEUROLOGY

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

(2022) X. Rosa Ma et al.   NATURE

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

(2022) Emmanuel O. Adewuyi et al.   Communications Biology

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

(2021) Jeremy Schwartzentruber et al.   NATURE GENETICS

Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers

(2021) Mica T. M. Clarke et al.   Alzheimers Research & Therapy

Pharmacotherapy for Frontotemporal Dementia

(2021) Rita Khoury et al.   CNS DRUGS

Ultrasensitive Detection of Alzheimer’s Amyloids on a Plasmonic-Gold Platform

(2021) Hsiao-Fen Han et al.   ACS Applied Materials & Interfaces

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

(2021) Wouter van Rheenen et al.   NATURE GENETICS

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

(2020) Nur Jury et al.   Clinical Epigenetics

A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

(2020) Yanjun Guo et al.   Nature Communications

A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis

(2020) Dan Zhou et al.   NATURE GENETICS

The role of glia in protein aggregation

(2020) Qingyun Li et al.   NEUROBIOLOGY OF DISEASE

Multivariate genome-wide analyses of the well-being spectrum

(2019) Bart M. L. Baselmans et al.   NATURE GENETICS

GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

(2019) Valentina Iotchkova et al.   NATURE GENETICS

An update on genetic frontotemporal dementia

(2019) Caroline V. Greaves et al.   JOURNAL OF NEUROLOGY

Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms

(2019) Cornelis Blauwendraat et al.   MOVEMENT DISORDERS

UNC13A variant rs12608932 is associated with increased risk of amyotrophic lateral sclerosis and reduced patient survival: a meta-analysis

(2019) Baiyuan Yang et al.   NEUROLOGICAL SCIENCES

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

(2019) Katrina M Moore et al.   LANCET NEUROLOGY

Pleiotropic mapping and annotation selection in genome-wide association studies with penalized Gaussian mixture models

(2018) Ping Zeng et al.   BIOINFORMATICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum

(2018) Celeste M. Karch et al.   JAMA Neurology

UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis

(2018) Katerina Placek et al.   NEUROBIOLOGY OF AGING

Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder

(2017) Noa Lipstein et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Therapy and clinical trials in frontotemporal dementia: past, present, and future

(2016) Richard M. Tsai et al.   JOURNAL OF NEUROCHEMISTRY

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases

(2016) Raffaele Ferrari et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling

(2016) Mathias A Böhme et al.   NATURE NEUROSCIENCE

The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others

(2016) Matthew A.J. Apps et al.   NEURON

Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits

(2016) Andrew Bakshi et al.   Scientific Reports

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia

(2015) Raffaele Ferrari et al.   NEUROBIOLOGY OF AGING

Basal ganglia pathology in ALS is associated with neuropsychological deficits

(2015) Judith Machts et al.   NEUROLOGY

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

(2015) Xuebing Ding et al.   Oncotarget

C9orf72andUNC13Aare shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: A genome-wide meta-analysis

(2014) Frank P. Diekstra et al.   ANNALS OF NEUROLOGY

Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy

(2014) A. Montuschi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Frontotemporal dementia and its subtypes: a genome-wide association study

(2014) Raffaele Ferrari et al.   LANCET NEUROLOGY

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Cardiovascular risk factors and frontotemporal dementia: a case–control study

(2014) Angel Golimstok et al.   Translational Neurodegeneration

Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis

(2013) J.-M. Bugnicourt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bradicardia en la demencia frontotemporal

(2013) A. Robles Bayón et al.   NEUROLOGIA

A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

(2012) Samsiddhi Bhattacharjee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

FTD and ALS: A Tale of Two Diseases

(2011) R. Ferrari et al.   Current Alzheimer Research

Phenotypic signatures of genetic frontotemporal dementia

(2011) Jonathan D. Rohrer et al.   CURRENT OPINION IN NEUROLOGY

Clinical Phenomenology and Neuroimaging Correlates in ALS-FTD

(2011) Catherine Lomen-Hoerth   JOURNAL OF MOLECULAR NEUROSCIENCE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

(2009) Michael A van Es et al.   NATURE GENETICS