Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling

Maturation of active zone assembly byDrosophilaBruchpilot

(2016) Wernher Fouquet et al.   JOURNAL OF CELL BIOLOGY

Ca2+ Channel to Synaptic Vesicle Distance Accounts for the Readily Releasable Pool Kinetics at a Functionally Mature Auditory Synapse

(2015) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

RIM-BPs Mediate Tight Coupling of Action Potentials to Ca 2+ -Triggered Neurotransmitter Release

(2015) Claudio Acuna et al.   NEURON

Nanoscale Distribution of Presynaptic Ca 2+ Channels and Its Impact on Vesicular Release during Development

(2015) Yukihiro Nakamura et al.   NEURON

An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse

(2015) Daniel Keller et al.   PLoS Computational Biology

Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone

(2015) Alexander Ullrich et al.   PLoS Computational Biology

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

(2015) Kwun Nok M Man et al.   eLife

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

(2014) Cordelia Imig et al.   NEURON

Coaligned Dual-Channel STED Nanoscopy and Molecular Diffusion Analysis at 20 nm Resolution

(2013) Fabian Göttfert et al.   BIOPHYSICAL JOURNAL

The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles

(2013) Tanja Matkovic et al.   JOURNAL OF CELL BIOLOGY

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission

(2013) Samantha A. Spangler et al.   JOURNAL OF CELL BIOLOGY

Synaptotagmin Interaction with SNAP-25 Governs Vesicle Docking, Priming, and Fusion Triggering

(2013) R. Mohrmann et al.   JOURNAL OF NEUROSCIENCE

Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca2+-Calmodulin-Munc13-1 Signaling

(2013) Noa Lipstein et al.   NEURON

UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans

(2013) Zhitao Hu et al.   eLife

Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome

(2012) Anna Hegele et al.   MOLECULAR CELL

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly

(2012) David Owald et al.   NATURE NEUROSCIENCE

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

Short-Term Presynaptic Plasticity

(2012) W. G. Regehr   Cold Spring Harbor Perspectives in Biology

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses

(2011) Emmanuel Eggermann et al.   NATURE REVIEWS NEUROSCIENCE

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

(2011) Yunyun Han et al.   NEURON

RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release

(2011) K. S. Y. Liu et al.   SCIENCE

A Syd-1 homologue regulates pre- and postsynaptic maturation inDrosophila

(2010) David Owald et al.   JOURNAL OF CELL BIOLOGY

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis

(2010) Alexander M. Walter et al.   JOURNAL OF CELL BIOLOGY

Naked Dense Bodies Provoke Depression

(2010) S. Hallermann et al.   JOURNAL OF NEUROSCIENCE

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid structural alterations of the active zone lead to sustained changes in neurotransmitter release

(2010) J. Matz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Vesicles in Mature Calyx of Held Synapses Sense Higher Nanodomain Calcium Concentrations during Action Potential-Evoked Glutamate Release

(2009) L.-Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Rab3 Dynamically Controls Protein Composition at Active Zones

(2009) Ethan R. Graf et al.   NEURON

Synaptotagmin Has an Essential Function in Synaptic Vesicle Positioning for Synchronous Release in Addition to Its Role as a Calcium Sensor

(2009) Samuel M. Young et al.   NEURON