Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

(2022) Philip S. Robinson et al.   Nature Communications

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation

(2022) Etienne Masle-Farquhar et al.   IMMUNITY

Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

(2021) Lei Wei et al.   Science Advances

The association between citrus consumption and melanoma risk in the UK Biobank

(2021) A.R. Marley et al.   BRITISH JOURNAL OF DERMATOLOGY

Somatic mutation landscapes at single-molecule resolution

(2021) Federico Abascal et al.   NATURE

A body map of somatic mutagenesis in morphologically normal human tissues

(2021) Ruoyan Li et al.   NATURE

The mutational landscape of human somatic and germline cells

(2021) Luiza Moore et al.   NATURE

Somatic Mutations in “Benign” Disease

(2021) Satu Mustjoki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Convergent somatic mutations in metabolism genes in chronic liver disease

(2021) Stanley W. K. Ng et al.   NATURE

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

(2021) Philip S. Robinson et al.   NATURE GENETICS

Somatic mutations provide important and unique insights into the biology of complex diseases

(2021) Sigurgeir Olafsson et al.   TRENDS IN GENETICS

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody

(2020) Mandeep Singh et al.   CELL

Tobacco smoking and somatic mutations in human bronchial epithelium

(2020) Kenichi Yoshida et al.   NATURE

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis

(2020) Sofie Vaengebjerg et al.   JAMA Dermatology

The mutational landscape of normal human endometrial epithelium

(2020) Luiza Moore et al.   NATURE

Somatic Evolution in Non-neoplastic IBD-Affected Colon

(2020) Sigurgeir Olafsson et al.   CELL

Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

(2020) Yahya Mahamat-Saleh et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

The genomic landscapes of individual melanocytes from human skin

(2020) Jessica Tang et al.   NATURE

Extensive heterogeneity in somatic mutation and selection in the human bladder

(2020) Andrew R. J. Lawson et al.   SCIENCE

Macroscopic somatic clonal expansion in morphologically normal human urothelium

(2020) Ruoyan Li et al.   SCIENCE

Selection of oncogenic mutant clones in normal human skin varies with body site

(2020) Joanna C Fowler et al.   Cancer Discovery

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

Pan-cancer whole-genome analyses of metastatic solid tumours

(2019) Peter Priestley et al.   NATURE

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver

(2019) Simon F. Brunner et al.   NATURE

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

(2019) Nobuyuki Kakiuchi et al.   NATURE

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

(2019) Kosaku Nanki et al.   NATURE

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

(2018) Irene Franco et al.   Nature Communications

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

(2018) Francis Blokzijl et al.   Genome Medicine

Population dynamics of normal human blood inferred from somatic mutations

(2018) Henry Lee-Six et al.   NATURE

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

(2018) Gareth J. Inman et al.   Nature Communications

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

(2018) Kazuaki Suda et al.   Cell Reports

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions

(2018) Sarah M. Urbut et al.   NATURE GENETICS

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

(2017) Katrina M de Lange et al.   NATURE GENETICS

Spatial constraints govern competition of mutant clones in human epidermis

(2017) M. D. Lynch et al.   Nature Communications

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

(2017) Lam C. Tsoi et al.   Nature Communications

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

(2017) Sigurgeir Olafsson et al.   npj Genomic Medicine

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

(2016) Stephan R Targan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

The Risk of Cancer in Patients With Psoriasis

(2016) Zelma C. Chiesa Fuxench et al.   JAMA Dermatology

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Citrus Consumption and Risk of Cutaneous Malignant Melanoma

(2015) Shaowei Wu et al.   JOURNAL OF CLINICAL ONCOLOGY

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Subclonal variant calling with multiple samples and prior knowledge

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Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Detecting and Estimating Contamination of Human DNA Samples in Sequencing and Array-Based Genotype Data

(2012) Goo Jun et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

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Carcinogenic risks of Psoralen UV-A therapy and Narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review

(2012) E. Archier et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

BEDTools: a flexible suite of utilities for comparing genomic features

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Allele-specific copy number analysis of tumors

(2010) P. Van Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The increase in melanoma: Are dietary furocoumarins responsible?

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