Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Authors
Keywords
-
Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-07-08
DOI
10.1038/s41467-022-31341-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Somatic mutation landscapes at single-molecule resolution
- (2021) Federico Abascal et al. NATURE
- The mutational landscape of human somatic and germline cells
- (2021) Luiza Moore et al. NATURE
- Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
- (2021) Philip S. Robinson et al. NATURE GENETICS
- Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli
- (2020) Cayetano Pleguezuelos-Manzano et al. NATURE
- Tobacco smoking and somatic mutations in human bronchial epithelium
- (2020) Kenichi Yoshida et al. NATURE
- The repertoire of mutational signatures in human cancer
- (2020) Ludmil B. Alexandrov et al. NATURE
- Genomic footprints of activated telomere maintenance mechanisms in cancer
- (2020) Lina Sieverling et al. Nature Communications
- The mutational landscape of normal human endometrial epithelium
- (2020) Luiza Moore et al. NATURE
- Somatic Evolution in Non-neoplastic IBD-Affected Colon
- (2020) Sigurgeir Olafsson et al. CELL
- Extensive heterogeneity in somatic mutation and selection in the human bladder
- (2020) Andrew R. J. Lawson et al. SCIENCE
- Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing
- (2020) Peter Ellis et al. Nature Protocols
- Duodenal Adenomas and Cancer in MUTYH-associated Polyposis: An International Cohort Study
- (2020) Laura E. Thomas et al. GASTROENTEROLOGY
- TelomereHunter – in silico estimation of telomere content and composition from cancer genomes
- (2019) Lars Feuerbach et al. BMC BIOINFORMATICS
- Somatic mutations and clonal dynamics in healthy and cirrhotic human liver
- (2019) Simon F. Brunner et al. NATURE
- The landscape of somatic mutation in normal colorectal epithelial cells
- (2019) Henry Lee-Six et al. NATURE
- Embryonal precursors of Wilms tumor
- (2019) Tim H. H. Coorens et al. SCIENCE
- Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis
- (2018) Pilar Mur et al. HUMAN MUTATION
- Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
- (2018) Daniel Temko et al. JOURNAL OF PATHOLOGY
- Intra-tumour diversification in colorectal cancer at the single-cell level
- (2018) Sophie F. Roerink et al. NATURE
- Somatic mutant clones colonize the human esophagus with age
- (2018) Iñigo Martincorena et al. SCIENCE
- The somatic mutation landscape of premalignant colorectal adenoma
- (2017) Shu-Hong Lin et al. GUT
- Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas
- (2017) Camilla Pilati et al. JOURNAL OF PATHOLOGY
- A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer
- (2017) Alessandra Viel et al. EBioMedicine
- Tissue-specific mutation accumulation in human adult stem cells during life
- (2016) Francis Blokzijl et al. NATURE
- COSMIC: somatic cancer genetics at high-resolution
- (2016) Simon A. Forbes et al. NUCLEIC ACIDS RESEARCH
- Functional Complementation Assay for 47MUTYHVariants in aMutY-DisruptedEscherichia ColiStrain
- (2015) Keigo Komine et al. HUMAN MUTATION
- Adenoma development in familial adenomatous polyposis andMUTYH-associated polyposis: somatic landscape and driver genes
- (2015) Mamunur Rashid et al. JOURNAL OF PATHOLOGY
- Clock-like mutational processes in human somatic cells
- (2015) Ludmil B Alexandrov et al. NATURE GENETICS
- High burden and pervasive positive selection of somatic mutations in normal human skin
- (2015) I. Martincorena et al. SCIENCE
- Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer
- (2014) Aung Ko Win et al. GASTROENTEROLOGY
- Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging
- (2014) Laila Ritsma et al. NATURE
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Mutational Processes Molding the Genomes of 21 Breast Cancers
- (2012) Serena Nik-Zainal et al. CELL
- Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
- (2012) Claire Palles et al. NATURE GENETICS
- Loss of MUTYH function in human cells leads to accumulation of oxidative damage and genetic instability
- (2012) V Ruggieri et al. ONCOGENE
- A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
- (2010) E Theodoratou et al. BRITISH JOURNAL OF CANCER
- Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
- (2010) Hugo J. Snippert et al. CELL
- Allele-specific copy number analysis of tumors
- (2010) P. Van Loo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer
- (2009) Sucharita Kundu et al. DNA REPAIR
- Expanded Extracolonic Tumor Spectrum in MUTYH-Associated Polyposis
- (2009) Stefanie Vogt et al. GASTROENTEROLOGY
- Clinical Implications of the Colorectal Cancer Risk Associated With MUTYH Mutation
- (2009) Steven J. Lubbe et al. JOURNAL OF CLINICAL ONCOLOGY
- Analysis of MUTYH Genotypes and Colorectal Phenotypes in Patients With MUTYH-Associated Polyposis
- (2008) Maartje Nielsen et al. GASTROENTEROLOGY
- Germline MutY Human Homologue Mutations and Colorectal Cancer: A Multisite Case-Control Study
- (2008) Sean P. Cleary et al. GASTROENTEROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now