Role of STAT3 in Genesis and Progression of Human Malignant Gliomas
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Role of STAT3 in Genesis and Progression of Human Malignant Gliomas
Authors
Keywords
STAT3, Glioma, Tyrosine 705, Serine 727
Journal
MOLECULAR NEUROBIOLOGY
Volume 54, Issue 8, Pages 5780-5797
Publisher
Springer Nature
Online
2016-09-22
DOI
10.1007/s12035-016-0103-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
- (2016) David N. Louis et al. ACTA NEUROPATHOLOGICA
- B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients
- (2016) Y. Yao et al. CLINICAL CANCER RESEARCH
- Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy
- (2016) Dongjun Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway
- (2016) Li Hong et al. JOURNAL OF NEURO-ONCOLOGY
- Control of glioblastoma tumorigenesis by feed-forward cytokine signaling
- (2016) Arezu Jahani-Asl et al. NATURE NEUROSCIENCE
- PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus
- (2016) Zhi-Sheng Xu et al. Journal of Molecular Cell Biology
- Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells
- (2016) Sarmistha Talukdar et al. Oncotarget
- Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion
- (2015) Chunhua Yu et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies
- (2015) A. L. Wong et al. ANNALS OF ONCOLOGY
- STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma
- (2015) Zangbéwendé Guy Ouédraogo et al. BRAIN PATHOLOGY
- Ceacam1L Modulates STAT3 Signaling to Control the Proliferation of Glioblastoma-Initiating Cells
- (2015) S. Kaneko et al. CANCER RESEARCH
- Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo
- (2015) P. Yue et al. CANCER RESEARCH
- STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
- (2015) J. Lau et al. CANCER RESEARCH
- Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies
- (2015) Michinori Ogura et al. CANCER SCIENCE
- Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial CellsNovelty and Significance
- (2015) Takuro Miyazaki et al. CIRCULATION RESEARCH
- Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells
- (2015) Xiaopeng Yuan et al. EXPERIMENTAL CELL RESEARCH
- The role of STAT3 in tumor-mediated immune suppression
- (2015) Sherise D. Ferguson et al. JOURNAL OF NEURO-ONCOLOGY
- Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma
- (2015) Mi Ok Yu et al. JOURNAL OF NEURO-ONCOLOGY
- Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727
- (2015) Eric Lam et al. MOLECULAR IMMUNOLOGY
- A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma
- (2015) Elizabeth R. Gerstner et al. NEURO-ONCOLOGY
- IGFBP2 potentiates nuclear EGFR–STAT3 signaling
- (2015) C Y Chua et al. ONCOGENE
- miR-506 functions as a tumor suppressor in glioma by targeting STAT3
- (2015) TAO PENG et al. ONCOLOGY REPORTS
- AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
- (2015) David Hong et al. Science Translational Medicine
- Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway
- (2015) Anwar Hossain et al. STEM CELLS
- Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway
- (2015) Ru-xiang Xu et al. Drug Design Development and Therapy
- Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells
- (2015) Jinlong Yin et al. PLOS BIOLOGY
- Oncostatin-M Differentially Regulates Mesenchymal and Proneural Signature Genes in Gliomas via STAT3 Signaling
- (2015) Kumar Natesh et al. NEOPLASIA
- IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells
- (2015) Hussein Akil et al. PLoS One
- JSI-124 Suppresses Invasion and Angiogenesis of Glioblastoma Cells In Vitro
- (2015) Guang Yuan et al. PLoS One
- Preclinical Evaluation of the Toxicological Effects of a Novel Constrained Ethyl Modified Antisense Compound Targeting Signal Transducer and Activator of Transcription 3 in Mice and Cynomolgus Monkeys
- (2015) Sebastien A. Burel et al. Nucleic Acid Therapeutics
- Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications
- (2015) Yunyun Jiang et al. Oncotarget
- Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
- (2014) E. M. Haapaniemi et al. BLOOD
- Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
- (2014) J. D. Milner et al. BLOOD
- Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 — Protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells
- (2014) Tapashi Mandal et al. CELLULAR SIGNALLING
- STAT3 is a central regulator of lymphocyte differentiation and function
- (2014) Alisa Kane et al. CURRENT OPINION IN IMMUNOLOGY
- Comparative screening and validation as a novel tool to identify STAT-specific inhibitors
- (2014) Małgorzata Szeląg et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3
- (2014) Maupali Dasgupta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of T-cell Protein-tyrosine Phosphatase Suppresses Keratinocyte Survival and Proliferation following UVB Irradiation
- (2014) Hyunseung Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish
- (2014) Y. Bu et al. JOURNAL OF CELL SCIENCE
- Inhibition of STAT3 Promotes the Efficacy of Adoptive Transfer Therapy Using Type-1 CTLs by Modulation of the Immunological Microenvironment in a Murine Intracranial Glioma
- (2014) M. Fujita et al. JOURNAL OF IMMUNOLOGY
- Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes
- (2014) Everardo Macias et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Knockdown of PKCε Expression Inhibits Growth, Induces Apoptosis and Decreases Invasiveness of Human Glioma Cells Partially Through Stat3
- (2014) Yaming Xu et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- STAT3 Tyr705 phosphorylation affects clinical outcome in patients with newly diagnosed supratentorial glioblastoma
- (2014) Guo-Shi Lin et al. MEDICAL ONCOLOGY
- Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway
- (2014) Meijuan Zou et al. MOLECULAR CARCINOGENESIS
- A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
- (2014) Mark R. Gilbert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma
- (2014) Olivier L. Chinot et al. NEW ENGLAND JOURNAL OF MEDICINE
- SHP-1 Arrests Mouse Early Embryo Development through Downregulation of Nanog by Dephosphorylation of STAT3
- (2014) Songna Yin et al. PLoS One
- Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis
- (2014) B. Ortiz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation
- (2014) P. Wang et al. SCIENCE
- Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727
- (2014) C Capron et al. Cell Death & Disease
- STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications
- (2014) Jennifer Kim et al. Cancers
- Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
- (2013) Parthasarathy Seshacharyulu et al. CANCER LETTERS
- SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma
- (2013) Fangli Ren et al. CELLULAR SIGNALLING
- The treatment of glioblastomas: A systematic update on clinical Phase III trials
- (2013) An-an Yin et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Proteome-wide discovery of mislocated proteins in cancer
- (2013) K. Lee et al. GENOME RESEARCH
- Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway
- (2013) Jo Meagan Garner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma
- (2013) Tracy T. Batchelor et al. JOURNAL OF CLINICAL ONCOLOGY
- STAT inhibitors for cancer therapy
- (2013) Muhammad Furqan et al. Journal of Hematology & Oncology
- Increased Signal Transducer and Activator of Transcription 3 (STAT3) and Decreased Cyclin D1 in Recurrent Astrocytic Tumours Compared with Paired Primary Astrocytic Tumours
- (2013) K Zhang et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- PTPN12 inhibits oral squamous epithelial carcinoma cell proliferation and invasion and can be used as a prognostic marker
- (2013) Zhe Su et al. MEDICAL ONCOLOGY
- Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma
- (2013) Guang-Yuh Chiou et al. MOLECULAR CELL
- The integrated landscape of driver genomic alterations in glioblastoma
- (2013) Veronique Frattini et al. NATURE GENETICS
- Therapeutic modulators of STAT signalling for human diseases
- (2013) Gabriella Miklossy et al. NATURE REVIEWS DRUG DISCOVERY
- STAT3 silencing inhibits glioma single cell infiltration and tumor growth
- (2013) M. Priester et al. NEURO-ONCOLOGY
- The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma
- (2012) Lee A.D. Cooper et al. AMERICAN JOURNAL OF PATHOLOGY
- STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
- (2012) A. Jerez et al. BLOOD
- The Definition of Primary and Secondary Glioblastoma
- (2012) H. Ohgaki et al. CLINICAL CANCER RESEARCH
- Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45
- (2012) Ryohei Wakahara et al. GENES TO CELLS
- Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3
- (2012) Jiajie Hou et al. HEPATOLOGY
- The role of STAT3 activation in modulating the immune microenvironment of GBM
- (2012) Alfred P. See et al. JOURNAL OF NEURO-ONCOLOGY
- Primary brain tumours in adults
- (2012) Damien Ricard et al. LANCET
- STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
- (2012) Shinji Kohsaka et al. MOLECULAR CANCER THERAPEUTICS
- Serine 727 phosphorylation of STAT3: An early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine
- (2012) Masaaki Miyakoshi et al. MOLECULAR CARCINOGENESIS
- Relationship of glioblastoma multiforme to the subventricular zone is associated with survival
- (2012) Nazia F. Jafri et al. NEURO-ONCOLOGY
- SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia
- (2012) Hanna L.M. Koskela et al. NEW ENGLAND JOURNAL OF MEDICINE
- Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma
- (2012) D Kesanakurti et al. ONCOGENE
- 14-3-3ζ Interacts with Stat3 and Regulates Its Constitutive Activation in Multiple Myeloma Cells
- (2012) Jia Zhang et al. PLoS One
- Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition
- (2012) Dinja Oosterhoff et al. OncoImmunology
- c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells
- (2011) J. C. Allen et al. BLOOD
- Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3
- (2011) Olga A. Guryanova et al. CANCER CELL
- Direct Effects of Type I Interferons on Cells of the Immune System
- (2011) S. Hervas-Stubbs et al. CLINICAL CANCER RESEARCH
- STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment
- (2011) A. Lavecchia et al. CURRENT MEDICINAL CHEMISTRY
- Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34+precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition
- (2011) Hester van Cruijsen et al. Immunotherapy
- A Complex of Nuclear Factor I-X3 and STAT3 Regulates Astrocyte and Glioma Migration through the Secreted Glycoprotein YKL-40
- (2011) Sandeep K. Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glioma-derived T Cell Immunoglobulin- and Mucin Domain-containing Molecule-4 (TIM4) Contributes to Tumor Tolerance
- (2011) Lunshan Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
- (2011) Yi-Ping Yang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways
- (2011) Chunsheng Kang ONCOLOGY REPORTS
- Hypoxia Potentiates Glioma-Mediated Immunosuppression
- (2011) Jun Wei et al. PLoS One
- STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: A potential for targeted therapy?
- (2010) Claire Villalva et al. INTERNATIONAL JOURNAL OF CANCER
- Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells
- (2010) Ren INTERNATIONAL JOURNAL OF ONCOLOGY
- Longitudinal MRI evidence for decreased survival among periventricular glioblastoma
- (2010) Geoffrey S. Young et al. JOURNAL OF NEURO-ONCOLOGY
- IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines
- (2010) Qinglin Liu et al. JOURNAL OF NEURO-ONCOLOGY
- STAT3 tyrosine phosphorylation influences survival in glioblastoma
- (2010) Peter Birner et al. JOURNAL OF NEURO-ONCOLOGY
- Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
- (2010) Christian Senft et al. JOURNAL OF NEURO-ONCOLOGY
- Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway
- (2010) J. Wei et al. MOLECULAR CANCER THERAPEUTICS
- Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma
- (2010) S. Kunwar et al. NEURO-ONCOLOGY
- Glioma cancer stem cells induce immunosuppressive macrophages/microglia
- (2010) Adam Wu et al. NEURO-ONCOLOGY
- Activated STAT3 Regulates Hypoxia-Induced Angiogenesis and Cell Migration in Human Glioblastoma
- (2010) Shin-Hyuk Kang et al. NEUROSURGERY
- Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2 and ERK1/2)
- (2010) M H Aziz et al. ONCOGENE
- IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1
- (2010) Li ONCOLOGY REPORTS
- Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation
- (2010) Dae Joon Kim et al. PLoS One
- Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
- (2010) J. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of STAT3 reverses drug resistance acquired in temozolomide-resistant human glioma cells
- (2010) EUN-SANG LEE et al. Oncology Letters
- Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model
- (2009) Yuan Wang et al. CANCER CELL
- Stat3 activation is required for the growth of U87 cell-derived tumours in mice
- (2009) Atreyi Dasgupta et al. EUROPEAN JOURNAL OF CANCER
- The transcriptional network for mesenchymal transformation of brain tumours
- (2009) Maria Stella Carro et al. NATURE
- MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
- (2009) Michael Weller et al. Nature Reviews Neurology
- The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers
- (2009) S. Veeriah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth
- (2009) Hui Wang et al. STEM CELLS
- STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells
- (2009) Maureen M. Sherry et al. STEM CELLS
- Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts
- (2009) Xing Fan et al. STEM CELLS
- Crystal structure of unphosphorylated STAT3 core fragment
- (2008) Zhiyong Ren et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells
- (2008) Jeongwu Lee et al. CANCER CELL
- Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation
- (2008) H. R. Qin et al. CANCER RESEARCH
- Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma
- (2008) D. A. Solomon et al. CANCER RESEARCH
- Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators
- (2008) H.-W. Lo et al. CLINICAL CANCER RESEARCH
- Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression
- (2008) E. C. Brantley et al. CLINICAL CANCER RESEARCH
- The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas
- (2008) M. Abou-Ghazal et al. CLINICAL CANCER RESEARCH
- Deregulation of a STAT3-Interleukin 8 Signaling Pathway Promotes Human Glioblastoma Cell Proliferation and Invasiveness
- (2008) N. de la Iglesia et al. JOURNAL OF NEUROSCIENCE
- Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas
- (2008) E. C. Brantley et al. MOLECULAR CANCER RESEARCH
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now