P66Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease

Chronic vagal nerve stimulation prevents high-salt diet-induced endothelial dysfunction and aortic stiffening in stroke-prone spontaneously hypertensive rats

(2016) Mark W. Chapleau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Serotonin in peripheral blood reflects oxidative stress and plays a crucial role in atherosclerosis: Novel insights toward holistic anti-atherothrombotic strategy

(2016) Tomonori Sugiura et al.   ATHEROSCLEROSIS

The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway

(2016) Jiong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol inhibits lipogenesis of 3T3-L1 and SGBS cells by inhibition of insulin signaling and mitochondrial mass increase

(2016) Shuijie Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling

(2016) Yanping Miao et al.   BRAIN RESEARCH BULLETIN

Microdomains, Inflammation, and Atherosclerosis

(2016) Mary G. Sorci-Thomas et al.   CIRCULATION RESEARCH

SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro

(2016) YING-WEI DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway

(2016) YI MA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

(2016) Mehmet Zuhuri Arun et al.   Drug Design Development and Therapy

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

(2016) Xiaoping Ji et al.   Drug Design Development and Therapy

The redox protein p66shc mediates cochlear vascular dysfunction and transient noise-induced hearing loss

(2016) A. R. Fetoni et al.   Scientific Reports

SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats

(2015) Mingge Ding et al.   Cardiovascular Diabetology

P53 Contributes to Cisplatin Induced Renal Oxidative Damage via Regulating P66shc and MnSOD

(2015) Yanggang Yuan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch

(2015) Kai Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

(2015) Heike Langbein et al.   EUROPEAN HEART JOURNAL

SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids

(2015) M. Tan et al.   FREE RADICAL RESEARCH

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

(2015) Yuliya Mikhed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Atherosclerosis Progression, Intimal Hyperplasia, and Oxidative Stress by Simvastatin and Ivabradine May Reduce Thoracic Aorta’s Stiffness in Hypercholesterolemic Rabbits

(2015) Ioanna Koniari et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway

(2015) Yanxiang Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow

(2015) Yorito Hattori et al.   NEUROREPORT

Oxidative stress in chronic vascular disease: From prediction to prevention

(2015) Francesca Santilli et al.   VASCULAR PHARMACOLOGY

Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1

(2015) Zhuangzhi Meng et al.   Experimental and Therapeutic Medicine

Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri

(2015) Chiara Priami et al.   Aging and Disease

Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 Shc -Regulated Reactive Oxygen Species

(2014) Ajit Vikram et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia

(2014) Santosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuin 1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury

(2014) Hu Yan et al.   CRITICAL CARE MEDICINE

The interplay between p66Shc, reactive oxygen species and cancer cell metabolism

(2014) Magdalena Lebiedzinska-Arciszewska et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene

(2014) Masaki Miyazawa et al.   MOLECULAR BIOLOGY OF THE CELL

Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage

(2014) Lingfei Ma et al.   TheScientificWorldJOURNAL

Endothelial dysfunction — A major mediator of diabetic vascular disease

(2013) Cristina M. Sena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C

(2013) Elena De Marchi et al.   Oxidative Medicine and Cellular Longevity

Cross-talk between SIRT1 and p66Shc in vascular diseases

(2013) Hou-Zao Chen et al.   TRENDS IN CARDIOVASCULAR MEDICINE

SIRT1 Regulates CD40 Expression Induced by TNF-a via NF-?B Pathway in Endothelial Cells

(2012) Lina Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

(2012) Francesco Paneni et al.   CIRCULATION RESEARCH

Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury

(2012) Remo D. Spescha et al.   EUROPEAN HEART JOURNAL

Mechanisms Involved in the Aging-Induced Vascular Dysfunction

(2012) Mariam El Assar et al.   Frontiers in Physiology

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc

(2011) Cuk-Seong Kim et al.   CARDIOVASCULAR RESEARCH

SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice

(2011) Li Li et al.   CIRCULATION RESEARCH

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

(2011) Xiao-Dong Cong et al.   INFLAMMATION

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

(2010) Catarina Rippe et al.   AGING CELL

Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway

(2010) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Protective Role of SIRT1 in Diabetic Vascular Dysfunction

(2009) Masayuki Orimo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resveratrol and Ischemic Preconditioning in the Brain

(2008) Ami Raval et al.   CURRENT MEDICINAL CHEMISTRY