Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95

The soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses

(2015) Margarita C. Dinamarca et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor

(2015) Klaus B. Nissen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function

(2015) Ken Uematsu et al.   JOURNAL OF NEUROCHEMISTRY

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

(2015) Annette M Vogl et al.   NATURE NEUROSCIENCE

Neddylation is needed for synapse maturation

(2015) Amy K Fu et al.   NATURE NEUROSCIENCE

Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation

(2015) Tomohiro Nakamura et al.   NEUROCHEMICAL RESEARCH

Fragile X Syndrome FMRP Co-localizes with Regulatory Targets PSD-95, GABA Receptors, CaMKIIα, and mGluR5 at Fiber Cell Membranes in the Eye Lens

(2015) Peter H. Frederikse et al.   NEUROCHEMICAL RESEARCH

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95

(2015) Anne-Sophie Hafner et al.   NEURON

Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK Loss

(2015) Jonathan M. Levy et al.   NEURON

The Physiology of Protein S-acylation

(2015) Luke H. Chamberlain et al.   PHYSIOLOGICAL REVIEWS

Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers

(2015) Juan F. Codocedo et al.   Frontiers in Cellular Neuroscience

Differential Distribution of Shank and GKAP at the Postsynaptic Density

(2015) Jung-Hwa Tao-Cheng et al.   PLoS One

Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

(2015) Klaus B. Nissen et al.   PLoS One

A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease

(2014) Armand Savioz et al.   AGEING RESEARCH REVIEWS

Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release

(2014) Y. Zhang et al.   EMBO JOURNAL

The Upregulation of NR2A-Containing N-Methyl-d-Aspartate Receptor Function by Tyrosine Phosphorylation of Postsynaptic Density 95 Via Facilitating Src/Proline-Rich Tyrosine Kinase 2 Activation

(2014) Chao Zhao et al.   MOLECULAR NEUROBIOLOGY

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors

(2014) Fernando J. Bustos et al.   PLoS One

Reconstitution of Multivalent PDZ Domain Binding to the Scaffold Protein PSD-95 Reveals Ternary-Complex Specificity of Combinatorial Inhibition

(2014) James J. McCann et al.   STRUCTURE

Wnt signaling in the nervous system and in Alzheimer's disease

(2014) N. C. Inestrosa et al.   Journal of Molecular Cell Biology

Copper: from neurotransmission to neuroproteostasis

(2014) Carlos M. Opazo et al.   Frontiers in Aging Neuroscience

Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin

(2013) Matthew P. Parsons et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local palmitoylation cycles define activity-regulated postsynaptic subdomains

(2013) Yuko Fukata et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of Threonine-19 of PSD-95 by GSK-3  is Required for PSD-95 Mobilization and Long-Term Depression

(2013) C. D. Nelson et al.   JOURNAL OF NEUROSCIENCE

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons

(2013) Berta Henriquez et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

(2013) Tomohiro Nakamura et al.   NEURON

Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors

(2013) Harold D. MacGillavry et al.   NEURON

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

(2012) Nien-Pei Tsai et al.   CELL

Calcyon Forms a Novel Ternary Complex with Dopamine D1Receptor through PSD-95 Protein and Plays a Role in Dopamine Receptor Internalization

(2012) Chang Man Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subsynaptic AMPA Receptor Distribution Is Acutely Regulated by Actin-Driven Reorganization of the Postsynaptic Density

(2012) J. M. Kerr et al.   JOURNAL OF NEUROSCIENCE

On the supertertiary structure of proteins

(2012) Peter Tompa   Nature Chemical Biology

PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

(2012) Sika Zheng et al.   NATURE NEUROSCIENCE

NeuroD2 regulates the development of hippocampal mossy fiber synapses

(2012) Scott A Wilke et al.   Neural Development

Supertertiary structure of the synaptic MAGuK scaffold proteins is conserved

(2012) J. J. McCann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eye opening and PSD95 are required for long-term potentiation in developing superior colliculus

(2012) J.-P. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease

(2012) Margarita C. Dinamarca et al.   Frontiers in Physiology

The Synaptic Protein Neuroligin-1 Interacts with the Amyloid β-Peptide. Is There a Role in Alzheimer’s Disease?

(2011) Margarita C. Dinamarca et al.   BIOCHEMISTRY

Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development

(2011) Sarah M. Cork et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TrkB and Protein Kinase M   Regulate Synaptic Localization of PSD-95 in Developing Cortex

(2011) A. Yoshii et al.   JOURNAL OF NEUROSCIENCE

Cyclin-Dependent Kinase 5 Regulates PSD-95 Ubiquitination in Neurons

(2011) M. J. Bianchetta et al.   JOURNAL OF NEUROSCIENCE

Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

(2011) Ravi S. Muddashetty et al.   MOLECULAR CELL

S-Nitrosylation and S-Palmitoylation Reciprocally Regulate Synaptic Targeting of PSD-95

(2011) Gary P.H. Ho et al.   NEURON

MAGUKs, Synaptic Development, and Synaptic Plasticity

(2011) Chan-Ying Zheng et al.   NEUROSCIENTIST

Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases

(2011) Fiona B. Young et al.   PROGRESS IN NEUROBIOLOGY

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation

(2010) K. P. de Arce et al.   JOURNAL OF NEUROSCIENCE

A three-step model for the synaptic recruitment of AMPA receptors

(2010) Patricio Opazo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

(2010) Waldo Cerpa et al.   Molecular Neurodegeneration

Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization

(2010) Matthieu Sainlos et al.   Nature Chemical Biology

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Fragile X Mental Retardation Protein Is Required for Synapse Elimination by the Activity-Dependent Transcription Factor MEF2

(2010) Brad E. Pfeiffer et al.   NEURON

TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers

(2010) Akio Sumioka et al.   NEURON

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia

(2010) B.W. LeBlanc et al.   NEUROSCIENCE

Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

(2010) L. Varela-Nallar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The postsynaptic density

(2009) Eunjoon Kim et al.   CURRENT BIOLOGY

Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons

(2009) Ginny G. Farías et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

(2009) Jun Noritake et al.   JOURNAL OF CELL BIOLOGY

Suppression of APP-containing vesicle trafficking and production of β-amyloid by AID/DHHC-12 protein

(2009) Chie Mizumaru et al.   JOURNAL OF NEUROCHEMISTRY

Distinct Domains within PSD-95 Mediate Synaptic Incorporation, Stabilization, and Activity-Dependent Trafficking

(2009) J. F. Sturgill et al.   JOURNAL OF NEUROSCIENCE

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

(2009) Wei Feng et al.   NATURE REVIEWS NEUROSCIENCE

Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia

(2008) Cai-Ping Du et al.   BIOCHEMICAL JOURNAL

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL

The role of post‐translational modifications for learning and memory formation

(2008) Berta Sunyer et al.   ELECTROPHORESIS

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS

Cell-permeable Peptide Tat-PSD-95 PDZ2 Inhibits Chronic Inflammatory Pain Behaviors in Mice

(2008) Feng Tao et al.   MOLECULAR THERAPY

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion

(2008) Jun Mukai et al.   NATURE NEUROSCIENCE

Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

(2008) Pascal Steiner et al.   NEURON

Molecular Dissociation of the Role of PSD-95 in Regulating Synaptic Strength and LTD

(2008) Weifeng Xu et al.   NEURON

Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins

(2008) C. Sager et al.   NEUROSCIENCE

Structural plasticity with preserved topology in the postsynaptic protein network

(2008) T. A. Blanpied et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization of the core structure of the postsynaptic density

(2008) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA