Gastrodin Regulates PI3K/AKT-Sirt3 Signaling Pathway and Proinflammatory Mediators in Activated Microglia

X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals

(2021) Shaohua Qi et al.   Journal of Neuroinflammation

MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6

(2021) Chang Cheng et al.   MOLECULAR MEDICINE

Age and sex differences in primary microglia culture: A comparative study

(2021) Conelius Ngwa et al.   JOURNAL OF NEUROSCIENCE METHODS

Hypoxic‐ischemic‐related cerebrovascular changes and potential therapeutic strategies in the neonatal brain

(2020) Clémence Disdier et al.   JOURNAL OF NEUROSCIENCE RESEARCH

IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

(2020) Juan Huang et al.   Journal of Neuroinflammation

IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH

(2020) Yang He et al.   NEUROSCIENCE

Distinct Residential and Infiltrated Macrophage Populations and Their Phagocytic Function in Mild and Severe Neonatal Hypoxic-Ischemic Brain Damage

(2020) Yingjun Min et al.   Frontiers in Cellular Neuroscience

C16 peptide and angiopoietin-1 protect against LPS-induced BV-2 microglial cell inflammation

(2020) Xiaoxiao Fu et al.   LIFE SCIENCES

Gastrodin Regulates the Notch Signaling Pathway and Sirt3 in Activated Microglia in Cerebral Hypoxic-Ischemia Neonatal Rats and in Activated BV-2 Microglia

(2020) Jing Guo et al.   NEUROMOLECULAR MEDICINE

Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer’s Disease

(2020) Wen Yang et al.   Oxidative Medicine and Cellular Longevity

CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia–reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation

(2020) Xiaolin Wang et al.   CANCER BIOLOGY & THERAPY

PI3K/ Akt/ mTOR pathway as a therapeutic target for colorectal cancer: A review of preclinical and clinical evidence

(2019) Arunaksharan Narayanankutty   CURRENT DRUG TARGETS

Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling

(2019) Kyeong-Eun Yang et al.   Journal of Ginseng Research

Inflammatory Responses are Sex Specific in Chronic Hypoxic–Ischemic Encephalopathy

(2018) Abdullah Al Mamun et al.   CELL TRANSPLANTATION

Adiponectin Attenuates Oxygen–Glucose Deprivation-Induced Mitochondrial Oxidative Injury and Apoptosis in Hippocampal HT22 Cells via the JAK2/STAT3 Pathway

(2018) Bodong Wang et al.   CELL TRANSPLANTATION

Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway

(2018) Chunyi Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Review on Central Nervous System Effects of Gastrodin

(2018) Yuan Liu et al.   Frontiers in Pharmacology

Gastrodin attenuates microglia activation through renin-angiotensin system and Sirtuin3 pathway

(2018) Shun-Jin Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Pyrroloquinoline quinine protects HK-2 cells against high glucose-induced oxidative stress and apoptosis through Sirt3 and PI3K/Akt/FoxO3a signaling pathway

(2018) Ziqiang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway

(2017) Chao Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

IL-17A Enhances Microglial Response to OGD by Regulating p53 and PI3K/Akt Pathways with Involvement of ROS/HMGB1

(2017) Bin Zhang et al.   Frontiers in Molecular Neuroscience

Early identification of hypoxic-ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy

(2016) Lili Guo et al.   Experimental and Therapeutic Medicine

Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy

(2015) Mehwish A Mirza et al.   Journal of Neuroinflammation

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Gastrodin Alleviates Cerebral Ischemic Damage in Mice by Improving Anti-oxidant and Anti-inflammation Activities and Inhibiting Apoptosis Pathway

(2015) Zhengwu Peng et al.   NEUROCHEMICAL RESEARCH

Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia

(2015) P. Rangarajan et al.   NEUROSCIENCE

Cognitive Outcomes After Neonatal Encephalopathy

(2015) A. Pappas et al.   PEDIATRICS

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

(2015) Douglas G. Walker et al.   Alzheimers Research & Therapy

Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats

(2014) Xiao-Hui Ma et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway

(2014) Yongliang Huang et al.   Oxidative Medicine and Cellular Longevity

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling

(2013) Ping Yang et al.   BIOCHEMICAL PHARMACOLOGY

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice

(2013) Stefano Fumagalli et al.   GLIA

Hyperbaric oxygenation reduces long-term brain injury and ameliorates behavioral function by suppression of apoptosis in a rat model of neonatal hypoxia–ischemia

(2013) Xiao-Hong Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Roles of Activated Microglia in Hypoxia Induced Neuroinflammation in the Developing Brain and the Retina

(2012) Charanjit Kaur et al.   Journal of Neuroimmune Pharmacology

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Gastrodin Inhibits Expression of Inducible NO Synthase, Cyclooxygenase-2 and Proinflammatory Cytokines in Cultured LPS-Stimulated Microglia via MAPK Pathways

(2011) Ji-Nan Dai et al.   PLoS One

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells: Reduction of oxidative stress and maintenance of the glutathione redox state

(2009) Masashi Hasegawa et al.   BRAIN RESEARCH

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells

(2008) J.J. Li et al.   NEUROSCIENCE

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA