IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells

(2019) Malgorzata Burek et al.   Translational Stroke Research

Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease

(2019) Josie C. van Kralingen et al.   Translational Stroke Research

Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic–ischemic encephalopathy

(2019) Yixin Zhang et al.   Cell Death & Disease

MiR-125a-5p promotes osteoclastogenesis by targeting TNFRSF1B

(2019) Liang Sun et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease

(2019) Alexis Martinez et al.   BIOLOGY OF THE CELL

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

(2019) Jaye M. Platnich et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Systematic review: long‐term cognitive and behavioural outcomes of neonatal hypoxic–ischaemic encephalopathy in children without cerebral palsy

(2019) Magdalena Schreglmann et al.   ACTA PAEDIATRICA

TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

(2019) Xing-Liang Yang et al.   Journal of Neuroinflammation

Early Pro-inflammatory Microglia Activation After Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats

(2019) Meray Serdar et al.   Frontiers in Cellular Neuroscience

PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway

(2019) Pingfu Hou et al.   ANGIOGENESIS

Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke

(2019) Yuan Zhang et al.   Translational Stroke Research

MicroRNA-125a-3p overexpression promotes liver regeneration through targeting proline-rich acidic protein 1

(2019) Xiaolin Wei et al.   Annals of Hepatology

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE

(2019) Juan Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism

(2019) Yuxiang Fan et al.   Cells

Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease

(2019) Shijia Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-125 inhibits colorectal cancer proliferation and invasion by targeting TAZ

(2019) Meiyuan Yang et al.   BIOSCIENCE REPORTS

The role of microRNAs in acute lymphoblastic leukaemia: From biology to applications

(2019) Behnam Emamgolizadeh Gurt Tapeh et al.   CELL BIOCHEMISTRY AND FUNCTION

The role of MicroRNAs on endoplasmic reticulum stress in myocardial ischemia and cardiac hypertrophy

(2019) Navid Omidkhoda et al.   PHARMACOLOGICAL RESEARCH

Selective mGluR1 Negative Allosteric Modulator Reduces Blood–Brain Barrier Permeability and Cerebral Edema After Experimental Subarachnoid Hemorrhage

(2019) Cheng Zhang et al.   Translational Stroke Research

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

(2018) Di Chen et al.   Journal of Neuroinflammation

Intranasal wnt3a attenuates neuronal apoptosis through Frz1/PIWIL1a/FOXM1 pathway in MCAO rats

(2018) Nathanael Matei et al.   JOURNAL OF NEUROSCIENCE

Histopathological study of encephalomalacia in neonatal calves and application of neuronal and axonal degeneration marker

(2018) Kenji KOYAMA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Photoaging and skin cancer: Is the inflammasome the missing link?

(2018) Fawaz Awad et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic–Ischemic Brain Injury

(2018) Liu Tu et al.   NEUROCHEMICAL RESEARCH

Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats

(2018) Ningbo Xu et al.   NEUROPHARMACOLOGY

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease

(2018) Yuan-Yuan Yuan et al.   Gastroenterology Report

Application of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Stroke: Biodistribution and MicroRNA Study

(2018) Gyeong Joon Moon et al.   Translational Stroke Research

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands

(2016) Hannah C. Feldman et al.   ACS Chemical Biology

Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice

(2016) Xuemei Bai et al.   BRAIN RESEARCH

Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia-ischemia

(2016) Raul Chavez-Valdez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Inhibition of microRNA-210 provides neuroprotection in hypoxic–ischemic brain injury in neonatal rats

(2016) Qingyi Ma et al.   NEUROBIOLOGY OF DISEASE

ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells

(2016) SHAOMIN SHI et al.   ONCOLOGY REPORTS

IRE1α pathway of endoplasmic reticulum stress induces neuronal apoptosis in the locus coeruleus of rats under single prolonged stress

(2016) Wei Zhao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Negative regulation of the inflammasome: keeping inflammation under control

(2015) Gustavo Pedraza-Alva et al.   IMMUNOLOGICAL REVIEWS

Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy

(2015) Brandon Dixon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IRE1α-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex

(2015) Xiaoyan Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic

(2014) Vanessa Ginet et al.   ANNALS OF NEUROLOGY

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: Role of protein synthesis and autophagic pathways

(2014) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Upregulation and lysosomal degradation of AQP4 in rat brains with bacterial meningitis

(2014) Juan Huang et al.   NEUROSCIENCE LETTERS

Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain

(2013) Catherine E. Creeley et al.   ANESTHESIOLOGY

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways

(2011) Gennadi V. Glinsky   CELL CYCLE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE