Evaluation of PEN2-ATP6AP1 axis as an antiparasitic target for metformin based on phylogeny analysis and molecular docking

Metformin and Its Immune-Mediated Effects in Various Diseases

(2023) Ichiro Nojima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

(2022) Teng Ma et al.   NATURE

Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8+ T Cells for Enhanced IFNγ Production by Metformin

(2022) Ruoyu Chao et al.   Frontiers in Immunology

The Potential Hepatoprotective Effect of Metformin in Hepatitis C Virus‐infected Adolescent Patients with Beta Thalassemia Major: Randomized Clinical Trial

(2021) Mona S. Abdel Monem et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

The antiviral effect of metformin on zika and dengue virus infection

(2021) Carlos Noe Farfan-Morales et al.   Scientific Reports

Metformin and Fibrosis: A Review of Existing Evidence and Mechanisms

(2021) Maoyan Wu et al.   Journal of Diabetes Research

Immune cell arrival kinetics to peritoneum and role during murine-experimental trichomoniasis

(2021) F. J. Rangel-Mata et al.   PARASITOLOGY

Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing

(2021) Elizabeth Varghese et al.   PLoS Pathogens

Metformin improves the therapeutic efficacy of low-dose albendazole against experimental alveolar echinococcosis

(2021) Julia A. Loos et al.   PARASITOLOGY

The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

(2020) Jessica Leismann et al.   EMBO REPORTS

Metformin-coated silver nanoparticles exhibit anti-acanthamoebic activities against both trophozoite and cyst stages

(2020) Ayaz Anwar et al.   EXPERIMENTAL PARASITOLOGY

Pharmacophore-Based Virtual Screening Toward the Discovery of Novel Anti-echinococcal Compounds

(2020) Congshan Liu et al.   Frontiers in Cellular and Infection Microbiology

Metformin suppresses development of the Echinococcus multilocularis larval stage targeting the TOR pathway

(2020) Julia A. Loos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gene Loss Predictably Drives Evolutionary Adaptation

(2020) Jana Helsen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Energy blackout against glycolytic parasites

(2020) Alba Martínez-Flórez et al.   International Journal for Parasitology-Drugs and Drug Resistance

Cellular and Molecular Mechanisms of Metformin Action

(2020) Traci E LaMoia et al.   ENDOCRINE REVIEWS

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly

(2020) Longfei Wang et al.   MOLECULAR CELL

Neutrophil interactions with the sexually transmitted parasite Trichomonas vaginalis: implications for immunity and pathogenesis

(2020) Suhani B. Bhakta et al.   Open Biology

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

(2019) Marc Foretz et al.   Nature Reviews Endocrinology

CDD/SPARCLE: the conserved domain database in 2020

(2019) Shennan Lu et al.   NUCLEIC ACIDS RESEARCH

Metformin promotes autophagy in Echinococcus granulosus larval stage

(2018) Julia A. Loos et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

Metformin as an Anticancer Agent

(2018) Ales Vancura et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism

(2018) Ahmed Alshawi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion

(2018) Mana Miyakoda et al.   Frontiers in Immunology

Metformin extends C. elegans lifespan through lysosomal pathway

(2017) Jie Chen et al.   eLife

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

(2017) Anna L Miles et al.   eLife

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

(2016) Hannah R. Bridges et al.   BMC BIOLOGY

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

Metformin and the gastrointestinal tract

(2016) Laura J. McCreight et al.   DIABETOLOGIA

Metformin prevents the effects ofPseudomonas aeruginosaon airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth

(2016) Wishwanath R. A. Patkee et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis

(2016) Jana Trifinopoulos et al.   NUCLEIC ACIDS RESEARCH

Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection

(2016) Ahmad A. Othman et al.   PARASITOLOGY INTERNATIONAL

ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation

(2016) Eric J. R. Jansen et al.   Nature Communications

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis

(2015) Sathish Babu Vasamsetti et al.   DIABETES

In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus

(2015) Julia A. Loos et al.   PLoS One

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis

(2014) Oliver Holmes et al.   BIOCHEMISTRY

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

The Effect of Pioglitazone and Metformin on Liver Function Tests, Insulin Resistance, and Liver Fat Content in Nonalcoholic Fatty Liver Disease: A Randomized Double Blinded Clinical Trial

(2013) Mohsen Razavizade et al.   Hepatitis Monthly

Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells

(2013) Y.-H. Xun et al.   JOURNAL OF VIRAL HEPATITIS

Metformin reduces airway glucose permeability and hyperglycaemia-inducedStaphylococcus aureusload independently of effects on blood glucose

(2013) James P Garnett et al.   THORAX

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens

(2013) Jason Brunton et al.   PLoS Pathogens

Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study

(2012)   DIABETES CARE

Metformin: a cheap and well-tolerated drug that provides benefits for viral infections

(2012) J Joven et al.   HIV MEDICINE

TreeGraph 2: Combining and visualizing evidence from different phylogenetic analyses

(2010) Ben C Stöver et al.   BMC BIOINFORMATICS

trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

(2009) S. Capella-Gutierrez et al.   BIOINFORMATICS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Metformin and the intestine

(2008) C. J. Bailey et al.   DIABETOLOGIA