Emilin2 fosters vascular stability by promoting pericyte recruitment

CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

(2023) Julia M. Houthuijzen et al.   Nature Communications

Antiangiogenesis: Vessel Regression, Vessel Normalization, or Both?

(2022) Hellmut G. Augustin et al.   CANCER RESEARCH

Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway

(2022) Eva Andreuzzi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Decreased EMILIN2 correlates to metabolism phenotype and poor prognosis of ovarian cancer

(2022) Xiaojian Tang et al.   JOURNAL OF BIOCHEMISTRY

EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction

(2022) Eliana Pivetta et al.   MATRIX BIOLOGY

Reflections on Integrins—Past, Present, and Future

(2022) Richard O. Hynes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors

(2022) Takahiko Akiyama et al.   CANCER RESEARCH

The Efficacy of Anti-PD-L1 Treatment in Melanoma Is Associated with the Expression of the ECM Molecule EMILIN2

(2021) Albina Fejza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage regulation of angiogenesis in health and disease

(2021) Paul Martin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Resistance Mechanisms to Anti-angiogenic Therapies in Cancer

(2020) Yolla Haibe et al.   Frontiers in Oncology

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment

(2019) Ming Yi et al.   Molecular Cancer

Multimerin-2 maintains vascular stability and permeability

(2019) Rosanna Pellicani et al.   MATRIX BIOLOGY

Extracellular matrix: the gatekeeper of tumor angiogenesis

(2019) Maurizio Mongiat et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth

(2018) Alice Paulitti et al.   ONCOGENE

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

(2018) Eva Andreuzzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis

(2017) Eva Andreuzzi et al.   MATRIX BIOLOGY

Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium

(2017) Federico Galvagni et al.   MATRIX BIOLOGY

CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity

(2017) Josephine B. Walton et al.   Scientific Reports

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Antiangiogenic cancer treatment: The great discovery and greater complexity (Review)

(2016) Ewa Maj et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antiangiogenic therapy in oncology: current status and future directions

(2016) Gordon C Jayson et al.   LANCET

The Extracellular Matrix Glycoprotein Elastin Microfibril Interface Located Protein 2: A Dual Role in the Tumor Microenvironment

(2015) Maurizio Mongiat et al.   NEOPLASIA

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review

(2014) A. B. Ariffin et al.   CANCER RESEARCH

Antiangiogenic Therapy for Glioblastoma: Current Status and Future Prospects

(2014) T. T. Batchelor et al.   CLINICAL CANCER RESEARCH

Recruitment and retention: factors that affect pericyte migration

(2013) Kristina Y. Aguilera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration

(2013) Stefano Marastoni et al.   JOURNAL OF PATHOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

The role of pericytes in angiogenesis

(2011) Domenico Ribatti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mesenchymal stem cell migration is regulated by fibronectin through  5 1-integrin-mediated activation of PDGFR-  and potentiation of growth factor signals

(2011) J. Veevers-Lowe et al.   JOURNAL OF CELL SCIENCE

Endothelial Cell-Pericyte Interactions Stimulate Basement Membrane Matrix Assembly: Influence on Vascular Tube Remodeling, Maturation, and Stabilization

(2011) Amber N. Stratman et al.   MICROSCOPY AND MICROANALYSIS

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

(2011) A. Bronisz et al.   NATURE CELL BIOLOGY

Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization

(2010) A. N. Stratman et al.   BLOOD

Identification of 5 novel genes methylated in breast and other epithelial cancers

(2010) Victoria K Hill et al.   Molecular Cancer

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

(2009) A. N. Stratman et al.   BLOOD

Integrins

(2008) Rita Silva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY