EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction

AXL Is a Potential Target for the Treatment of Intestinal Fibrosis

(2020) Calen A Steiner et al.   INFLAMMATORY BOWEL DISEASES

Distinct extracellular–matrix remodeling events precede symptoms of inflammation

(2020) Elee Shimshoni et al.   MATRIX BIOLOGY

Keratinocyte integrin α3β1 promotes secretion of IL-1α to effect paracrine regulation of fibroblast gene expression and differentiation

(2019) Rui Zheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Psoriasis and the TNF/IL23/IL17 axis

(2019) Kazuhisa Furue et al.   GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis

(2019) Alessandra Capuano et al.   MATRIX BIOLOGY

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

(2019) Kenneth W. Finnson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Changes in extracellular matrix in subcutaneous small resistance arteries of patients with essential hypertension

(2018) Gaia Favero et al.   BLOOD PRESSURE

New insights into TGF-β/Smad signaling in tissue fibrosis

(2018) He-He Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation

(2018) Shang-Hung Lin et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The α4β1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement

(2018) Alessandra Capuano et al.   MATRIX BIOLOGY

CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing

(2018) Priya Govindaraju et al.   MATRIX BIOLOGY

Inflammation and fibrosis

(2018) Matthias Mack   MATRIX BIOLOGY

Integrin binding site within the gC1q domain orchestrates EMILIN-1-induced lymphangiogenesis

(2018) Alessandra Capuano et al.   MATRIX BIOLOGY

Neutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity

(2017) Orlando Maiorani et al.   Scientific Reports

Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model

(2016) E. Pivetta et al.   CLINICAL SCIENCE

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

(2015) Igor Malyshev et al.   Biomed Research International

TGF-  mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

(2014) C. Munjal et al.   Disease Models & Mechanisms

Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1

(2014) Eliana Pivetta et al.   MATRIX BIOLOGY

The VEGF-C/VEGFR3 signaling pathway contributes to resolving chronic skin inflammation by activating lymphatic vessel function

(2013) Asami Hagura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

EMILIN1/α9β1 Integrin Interaction Is Crucial in Lymphatic Valve Formation and Maintenance

(2013) Carla Danussi et al.   MOLECULAR AND CELLULAR BIOLOGY

An EMILIN1-Negative Microenvironment Promotes Tumor Cell Proliferation and Lymph Node Invasion

(2012) C. Danussi et al.   Cancer Prevention Research

Tissue stroma as a regulator of leukocyte recruitment in inflammation

(2012) Helen M. McGettrick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

EMILIN1–α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation

(2011) Carla Danussi et al.   JOURNAL OF CELL BIOLOGY

Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: An approach of vascular development chronology in psoriasis

(2010) Audrey Henno et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Emilin1 Deficiency Causes Structural and Functional Defects of Lymphatic Vasculature

(2008) C. Danussi et al.   MOLECULAR AND CELLULAR BIOLOGY

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

(2008) Ulrike Lichti et al.   Nature Protocols