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Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology

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The Efficacy of Anti-PD-L1 Treatment in Melanoma Is Associated with the Expression of the ECM Molecule EMILIN2

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ECM Remodeling in Squamous Cell Carcinoma of the Aerodigestive Tract: Pathways for Cancer Dissemination and Emerging Biomarkers

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Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

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Immune overdrive signature in colorectal tumor subset predicts poor clinical outcome

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Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis

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Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression

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An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

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Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors

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Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas

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The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth

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Lysyl-tRNA synthetase–expressing colon spheroids induce M2 macrophage polarization to promote metastasis

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A functional genomics predictive network model identifies regulators of inflammatory bowel disease

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LinkedOmics: analyzing multi-omics data within and across 32 cancer types

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mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages

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Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages

(2017) Elisabeth Müller et al.   Frontiers in Immunology

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

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Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

(2016) Thomas Welte et al.   NATURE CELL BIOLOGY

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G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers

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Deficiency of Interferon-Gamma or Its Receptor Promotes Colorectal Cancer Development

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The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis

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The activating effect of IFN-γ on monocytes/macrophages is regulated by the LIF–trophoblast–IL-10 axis via Stat1 inhibition and Stat3 activation

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ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation

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In silico and Ex vivo approaches identify a role for toll-like receptor 4 in colorectal cancer

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EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration

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Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer

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(2010) Sergei I. Grivennikov et al.   CELL

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(2010) Alberto Mantovani   EUROPEAN JOURNAL OF IMMUNOLOGY

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Identification of 5 novel genes methylated in breast and other epithelial cancers

(2010) Victoria K Hill et al.   Molecular Cancer

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