Melatonin alleviates acute respiratory distress syndrome by inhibiting alveolar macrophage NLRP3 inflammasomes through the ROS/HIF-1α/GLUT1 pathway

Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis

(2023) Dexin Shen et al.   Cell Death & Disease

Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model

(2022) Hanseul Park et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates PM2.5-triggered macrophage M1 polarization and atherosclerosis via regulating NOX2-mediated oxidative stress homeostasis

(2022) Jiangyan Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of melatonin on protecting against lung injury (Review)

(2021) Weiwei Wang et al.   Experimental and Therapeutic Medicine

Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming

(2021) Chao Gu et al.   AGING CELL

Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway

(2021) Sanchun Wang et al.   Cancer Cell International

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis

(2021) Rahul Y. Mahida et al.   EUROPEAN RESPIRATORY JOURNAL

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

(2021) Hongxu Xian et al.   IMMUNITY

Protective effect of melatonin entrapped PLGA nanoparticles on radiation-induced lung injury through the miR-21/TGF-β1/Smad3 pathway

(2021) Shuang Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Paraquat promotes acute lung injury in rats by regulating alveolar macrophage polarization through glycolysis

(2021) Yan Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation

(2021) Lirong Liang et al.   JOURNAL OF PINEAL RESEARCH

Suppression of lncRNA NLRP3 inhibits NLRP3-triggered inflammatory responses in early acute lung injury

(2021) Deqiang Luo et al.   Cell Death & Disease

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Combination of melatonin and irisin ameliorates lipopolysaccharide‐induced cardiac dysfunction through suppressing the Mst1–JNK pathways

(2020) Haichun Ouyang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

(2020) Koen Veys et al.   CIRCULATION RESEARCH

Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway

(2020) Yue Xu et al.   JOURNAL OF PINEAL RESEARCH

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210/ISCU Axis Activation

(2020) Mindi He et al.   Oxidative Medicine and Cellular Longevity

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Attenuate LPS-Induced ARDS by Modulating Macrophage Polarization Through Inhibiting Glycolysis in Macrophages

(2020) Huimin Deng et al.   SHOCK

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

(2020) Felix Renaudin et al.   ANNALS OF THE RHEUMATIC DISEASES

α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome

(2020) Zhukai Cong et al.   CLINICAL SCIENCE

Melatonin Protects Mouse Testes from Palmitic Acid‐Induced Lipotoxicity by Attenuating Oxidative Stress and DNA Damage in a SIRT1‐Dependent Manner

(2020) Dejun Xu et al.   JOURNAL OF PINEAL RESEARCH

Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1α, HSP-70 and VEGF Pathways in Rat’s Kidneys Induced by Hypoxic Stress

(2020) Aliah R. Alshanwani et al.   Dose-Response

Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development

(2020) Lingli Zhou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury

(2020) Bisheng Zhou et al.   NATURE IMMUNOLOGY

Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets

(2020) Justina Kulikauskaite et al.   TRENDS IN IMMUNOLOGY

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

(2020) Elisabeth Jäger et al.   Nature Communications

Melatonin in macrophage biology: Current understanding and future perspectives

(2019) Yaoyao Xia et al.   JOURNAL OF PINEAL RESEARCH

α-Ketoglutarate Modulates Macrophage Polarization Through Regulation of PPARγ Transcription and mTORC1/p70S6K Pathway to Ameliorate ALI/ARDS

(2019) Meiyun Liu et al.   SHOCK

HIF-1α as a central mediator of cellular resistance to intracellular pathogens

(2019) Matthew Knight et al.   CURRENT OPINION IN IMMUNOLOGY

NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass

(2018) Lei Hou et al.   LABORATORY INVESTIGATION

The Role of Macrophages in the Pathogenesis of ALI/ARDS

(2018) Xiaofang Huang et al.   MEDIATORS OF INFLAMMATION

HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development

(2018) Liang Zhou et al.   Nature Communications

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator

(2017) Cheng-kun Wang et al.   JOURNAL OF PINEAL RESEARCH

Acute Respiratory Distress Syndrome

(2017) B. Taylor Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

(2015) Shahrzad Movafagh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma

(2015) Lulu Mao et al.   JOURNAL OF PINEAL RESEARCH

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Advances in Understanding of the Pathogenesis of Acute Respiratory Distress Syndrome

(2015) Charles Sharp et al.   RESPIRATION

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized Low-Density Lipoprotein Stimulates Macrophage 18F-FDG Uptake via Hypoxia-Inducible Factor-1  Activation Through Nox2-Dependent Reactive Oxygen Species Generation

(2014) S. J. Lee et al.   JOURNAL OF NUCLEAR MEDICINE

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Activation of NLRP3 Inflammasome in Alveolar Macrophages Contributes to Mechanical Stretch-Induced Lung Inflammation and Injury

(2013) J. Wu et al.   JOURNAL OF IMMUNOLOGY

Influence of melatonin receptor signalling on parameters involved in blood glucose regulation

(2013) Ivonne Bazwinsky-Wutschke et al.   JOURNAL OF PINEAL RESEARCH

Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury

(2012) Hon-Kan Yip et al.   JOURNAL OF PINEAL RESEARCH

Increase in GLUT1 in Smooth Muscle Alters Vascular Contractility and Increases Inflammation in Response to Vascular Injury

(2010) Neeta Adhikari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY