Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors

(2023) Ana Ruiz-Saenz et al.   Nature Cancer

Blocking EGFR with nimotuzumab: a novel strategy for COVID-19 treatment

(2022) Henrry Diaz Londres et al.   Immunotherapy

Oxidative Damage Induces a Vacancy G-Quadruplex That Binds Guanine Metabolites: Solution Structure of a cGMP Fill-in Vacancy G-Quadruplex in the Oxidized BLM Gene Promoter

(2022) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer

(2022) Anna Gogleva et al.   Nature Communications

Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes

(2022) Liu-Yi Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymerase η Recruits DHX9 Helicase to Promote Replication across Guanine Quadruplex Structures

(2022) Feng Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial

(2022) Shun Lu et al.   LANCET ONCOLOGY

EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation

(2022) Gao Guo et al.   NATURE CELL BIOLOGY

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial

(2022) Andrea Sartore-Bianchi et al.   NATURE MEDICINE

Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

(2022) Xinlei Zhuang et al.   Nature Communications

DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting

(2022) Luying Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Phen‐DC 3 Induces Refolding of Human Telomeric DNA into a Chair‐Type Antiparallel G‐Quadruplex through Ligand Intercalation

(2022) Anirban Ghosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An RNA G‐Quadruplex Structure within the ADAR 5’UTR Interacts with DHX36 Helicase to Regulate Translation

(2022) Kaixin Lyu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

(2022) Kai-Bo Wang et al.   Nature Communications

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

(2021) Runping Fang et al.   Nature Communications

G-quadruplexes: a promising target for cancer therapy

(2021) Nils Kosiol et al.   Molecular Cancer

Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling

(2021) Xinya Gao et al.   NATURE CELL BIOLOGY

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

(2021) Bas Ponsioen et al.   NATURE CELL BIOLOGY

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

(2021) Victoria Gudiño et al.   Nature Communications

Chemical Modulation of DNA Replication along G-Quadruplex Based on Topology-Dependent Ligand Binding

(2021) Shuntaro Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-based classification predicts drug response in EGFR-mutant NSCLC

(2021) Jacqulyne P. Robichaux et al.   NATURE

EGFR activation limits the response of liver cancer to lenvatinib

(2021) Haojie Jin et al.   NATURE

Chemical profiling of DNA G-quadruplex-interacting proteins in live cells

(2021) Xiaoyun Zhang et al.   Nature Chemistry

DNA G-quadruplex structures: more than simple roadblocks to transcription?

(2021) Jenna Robinson et al.   NUCLEIC ACIDS RESEARCH

Solution Structure of Ternary Complex of Berberine Bound to a dGMP–Fill-In Vacancy G-Quadruplex Formed in the PDGFR-β Promoter

(2021) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment

(2021) Alex Friedlaender et al.   Nature Reviews Clinical Oncology

Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter

(2021) Juan-nan Chen et al.   NUCLEIC ACIDS RESEARCH

PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can be Filled-in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs

(2020) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan‐cancer analysis

(2020) Haijing Liu et al.   Cancer Communications

Structure of two G-quadruplexes in equilibrium in the KRAS promoter

(2020) Julien Marquevielle et al.   NUCLEIC ACIDS RESEARCH

A Thermodynamic Perspective on Potential G‐Quadruplex Structures as Silencer Elements in the MYC Promoter

(2020) Jagannath Jana et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine–Peptide Conjugate

(2020) Yi-de He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Landscape of G-quadruplex DNA structural regions in breast cancer

(2020) Robert Hänsel-Hertsch et al.   NATURE GENETICS

An aberrant STAT pathway is central to COVID-19

(2020) Toshifumi Matsuyama et al.   CELL DEATH AND DIFFERENTIATION

Detection of genomic G-quadruplexes in living cells using a small artificial protein

(2020) Ke-wei Zheng et al.   NUCLEIC ACIDS RESEARCH

Non-duplex G-Quadruplex DNA Structure: A Developing Story from Predicted Sequences to DNA Structure-Dependent Epigenetics and Beyond

(2020) Antara Sengupta et al.   ACCOUNTS OF CHEMICAL RESEARCH

DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

(2020) Jessica J. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC

(2019) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides

(2019) Fernaldo Richtia Winnerdy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC

(2019) Suresh S. Ramalingam et al.   NEW ENGLAND JOURNAL OF MEDICINE

G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy

(2018) Rafael del Villar-Guerra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter

(2017) Maria L. Greco et al.   NUCLEIC ACIDS RESEARCH

Quadruplex Nucleic Acids as Novel Therapeutic Targets

(2016) Stephen Neidle   JOURNAL OF MEDICINAL CHEMISTRY

A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription

(2016) Buket Onel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

(2016) Hyun-Jin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule binding

(2015) Brahim Heddi et al.   NUCLEIC ACIDS RESEARCH

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study

(2015) K. W. Lim et al.   NUCLEIC ACIDS RESEARCH

Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives

(2015) Xin-min Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha

(2013) Joachim Lupberger et al.   HEPATOLOGY

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

(2013) Vineeth Thachappilly Mukundan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale

(2013) Barira Islam et al.   NUCLEIC ACIDS RESEARCH

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β Promoter Adopts a Novel Broken-Strand Structure in K+ Solution

(2012) Yuwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Cloning of the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter and Drug Targeting of the G-Quadruplex-Forming Region To Repress PDGFR-β Expression

(2010) Yong Qin et al.   BIOCHEMISTRY