Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

Oxidative Damage Induces a Vacancy G-Quadruplex That Binds Guanine Metabolites: Solution Structure of a cGMP Fill-in Vacancy G-Quadruplex in the Oxidized BLM Gene Promoter

(2022) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy

(2021) Peter A. Summers et al.   Nature Communications

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter

(2021) Stasė Bielskutė et al.   NUCLEIC ACIDS RESEARCH

Selectivity and Targeting of G‐quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics

(2021) Bo-Chen Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

G-Quadruplexes as pathogenic drivers in neurodegenerative disorders

(2021) Ernest Wang et al.   NUCLEIC ACIDS RESEARCH

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes

(2021) Jonathan Dickerhoff et al.   NUCLEIC ACIDS RESEARCH

A KRAS-responsive long non-coding RNA controls microRNA processing

(2021) Lei Shi et al.   Nature Communications

Targeting KRAS in non-small-cell lung cancer: recent progress and new approaches

(2021) M. Reck et al.   ANNALS OF ONCOLOGY

Emerging strategies to target RAS signaling in human cancer therapy

(2021) Kun Chen et al.   Journal of Hematology & Oncology

Chemical Modulation of DNA Replication along G-Quadruplex Based on Topology-Dependent Ligand Binding

(2021) Shuntaro Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical profiling of DNA G-quadruplex-interacting proteins in live cells

(2021) Xiaoyun Zhang et al.   Nature Chemistry

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

(2021) Ferdinandos Skoulidis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acquired Resistance to KRASG12C Inhibition in Cancer

(2021) Mark M. Awad et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA G-quadruplex structures: more than simple roadblocks to transcription?

(2021) Jenna Robinson et al.   NUCLEIC ACIDS RESEARCH

The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology

(2021) Jielin Chen et al.   NUCLEIC ACIDS RESEARCH

Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

(2021) Sara Lago et al.   Nature Communications

Single‐Cell Visualization of Monogenic RNA G‐quadruplex and Occupied G‐quadruplex Ratio through a Module‐Assembled Multifunctional Probes Assay (MAMPA)

(2021) Yicong Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

KRAS Inhibitors– yes but what next? Direct targeting of KRAS– vaccines, adoptive T cell therapy and beyond

(2021) Misako Nagasaka et al.   CANCER TREATMENT REVIEWS

Berberine Molecular Recognition of the Parallel MYC G-Quadruplex in Solution

(2021) Jonathan Dickerhoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution Structure of Ternary Complex of Berberine Bound to a dGMP–Fill-In Vacancy G-Quadruplex Formed in the PDGFR-β Promoter

(2021) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct genome-wide identification of G-quadruplex structures by whole-genome resequencing

(2021) Jing Tu et al.   Nature Communications

PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can be Filled-in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs

(2020) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer

(2020) Louis Buscail et al.   Nature Reviews Gastroenterology & Hepatology

Content Detection of G‐Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structures

(2020) Liu-Yi Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Structure of two G-quadruplexes in equilibrium in the KRAS promoter

(2020) Julien Marquevielle et al.   NUCLEIC ACIDS RESEARCH

High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition

(2020) Arnold Ou et al.   NUCLEIC ACIDS RESEARCH

A Thermodynamic Perspective on Potential G‐Quadruplex Structures as Silencer Elements in the MYC Promoter

(2020) Jagannath Jana et al.   CHEMISTRY-A EUROPEAN JOURNAL

Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

(2020) Guanhui Wu et al.   MOLECULES

RAS-targeted therapies: is the undruggable drugged?

(2020) Amanda R. Moore et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting KRAS(G12C): From Inhibitory Mechanism to Modulation of Antitumor Effects in Patients

(2020) Dongsung Kim et al.   CELL

Detection of genomic G-quadruplexes in living cells using a small artificial protein

(2020) Ke-wei Zheng et al.   NUCLEIC ACIDS RESEARCH

DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

(2020) Jessica J. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC

(2019) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

(2019) Jude Canon et al.   NATURE

Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures

(2018) Clement Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy

(2018) Rafael del Villar-Guerra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

(2018) Gabrielle S. Wong et al.   NATURE MEDICINE

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

(2018) Jussara Amato et al.   CHEMICAL COMMUNICATIONS

Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

(2018) Wenting Liu et al.   Nature Communications

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

(2018) David R. Calabrese et al.   Nature Communications

High-resolution three-dimensional NMR structure of theKRASproto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

(2017) Abdelaziz Kerkour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

(2017) Christine E. Kaiser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription

(2017) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Spectroscopic investigation of the interaction between G-quadruplex of KRAS promoter sequence and three isoquinoline alkaloids

(2017) Li-Na Wen et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex

(2016) Anita Kotar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interaction of KRAS G-quadruplex with natural polyphenols: A spectroscopic analysis with molecular modeling

(2016) Rudradip Pattanayak et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

A Series of β-Carboline Alkaloids from the Seeds of Peganum harmala Show G-Quadruplex Interactions

(2016) Kai-Bo Wang et al.   ORGANIC LETTERS

Refinement of the Sugar–Phosphate Backbone Torsion Beta for AMBER Force Fields Improves the Description of Z- and B-DNA

(2015) Marie Zgarbová et al.   Journal of Chemical Theory and Computation

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

(2015) João Lavrado et al.   Scientific Reports

Toward Improved Description of DNA Backbone: Revisiting Epsilon and Zeta Torsion Force Field Parameters

(2013) Marie Zgarbová et al.   Journal of Chemical Theory and Computation

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

Reference Simulations of Noncanonical Nucleic Acids with Different χ Variants of the AMBER Force Field: Quadruplex DNA, Quadruplex RNA, and Z-DNA

(2012) Miroslav Krepl et al.   Journal of Chemical Theory and Computation

Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE

(2011) Manikandan Paramasivam et al.   CHEMICAL COMMUNICATIONS

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

(2008) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH