Illuminating drug action by network integration of disease genes: a case study of myocardial infarction

A comparative study of disease genes and drug targets in the human protein interactome

(2015) Jingchun Sun et al.   BMC BIOINFORMATICS

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

Enhancement of Matrix Metalloproteinase 2 and 9 Inhibitory Action of Minocycline by Aspirin: An Approach to Attenuate Outcome of Acute Myocardial Infarction in Diabetes

(2014) Lokesh K. Bhatt et al.   ARCHIVES OF MEDICAL RESEARCH

Insights from systems pharmacology into cardiovascular drug discovery and therapy

(2014) Peng Li et al.   BMC Systems Biology

Identification of Drug-Induced Myocardial Infarction-Related Protein Targets through the Prediction of Drug–Target Interactions and Analysis of Biological Processes

(2014) Sergey M. Ivanov et al.   CHEMICAL RESEARCH IN TOXICOLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Is Sodium Valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case-control study

(2014) Alex Dregan et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Inferring drug-disease associations from integration of chemical, genomic and phenotype data using network propagation

(2013) Yu-Fen Huang et al.   BMC Medical Genomics

Phenotype–Genotype Integrator (PheGenI): synthesizing genome-wide association study (GWAS) data with existing genomic resources

(2013) Erin M Ramos et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Integrative approaches for finding modular structure in biological networks

(2013) Koyel Mitra et al.   NATURE REVIEWS GENETICS

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

(2013) Peter Csermely et al.   PHARMACOLOGY & THERAPEUTICS

Prediction of Adverse Cardiovascular Events of Noncardiovascular Drugs through Drug-Target Interaction Networks

(2012) Francisco J. Azuaje et al.   CTS-Clinical and Translational Science

Antifungal Miconazole Induces Cardiotoxicity Via Inhibition of APE/Ref-1-Related Pathway in Rat Neonatal Cardiomyocytes

(2012) Kyung-Jong Won et al.   TOXICOLOGICAL SCIENCES

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

(2012) Feixiong Cheng et al.   PLoS Computational Biology

Predicting adverse side effects of drugs

(2011) Liang-Chin Huang et al.   BMC GENOMICS

Therapeutic Potential of Ginseng in the Management of Cardiovascular Disorders

(2011) Morris Karmazyn et al.   DRUGS

Ginseng protects rodent hearts from acute myocardial ischemia–reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism

(2011) Hua Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

(2011) Lucas Brouwers et al.   PLoS One

Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs

(2011) Francisco J. Azuaje et al.   Scientific Reports

Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework

(2010) Y. Yamanishi et al.   BIOINFORMATICS

Mitochondrial aldehyde dehydrogenase and cardiac diseases

(2010) Che-Hong Chen et al.   CARDIOVASCULAR RESEARCH

A case oftorsades de pointesinduced by severe QT prolongation after an overdose of eperisone and triazolam in a patient receiving nifedipine

(2010) Takeshi Yamagiwa et al.   CLINICAL TOXICOLOGY

Plasticity of GABAergic Mechanisms Within the Nucleus of the Solitary Tract in Hypertension

(2010) Weirong Zhang et al.   HYPERTENSION

Risk of Acute Myocardial Infarction, Stroke, Heart Failure, and Death in Elderly Medicare Patients Treated With Rosiglitazone or Pioglitazone

(2010) David J. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study

(2010) Jonas Bjerring Olesen et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Increased Mortality and Cardiovascular Morbidity Associated With Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure

(2009) Gunnar H. Gislason et al.   ARCHIVES OF INTERNAL MEDICINE

GS2: an efficiently computable measure of GO-based similarity of gene sets

(2009) T. Ruths et al.   BIOINFORMATICS

Phenopedia and Genopedia: disease-centered and gene-centered views of the evolving knowledge of human genetic associations

(2009) W. Yu et al.   BIOINFORMATICS

Cardiovascular Effects of Noncardiovascular Drugs

(2009) Satish R. Raj et al.   CIRCULATION

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Acetaminophen Is Cardioprotective Against H2O2-Induced Injury In Vivo

(2008) Kathryn M. Jaques-Robinson et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

On Modularity Clustering

(2008) U. Brandes et al.   IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING

Proarrhythmic Potential of Antimicrobial Agents

(2008) J. Simkó et al.   INFECTION

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT

Quantitative function for community detection

(2008) Zhenping Li et al.   PHYSICAL REVIEW E

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE