IKK  Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei

(2012) Patrícia O. Prada et al.   DIABETES

Hypothalamic Astrocytes in Obesity

(2012) Cristina García-Cáceres et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice

(2011) Ludger Scheja et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel cross-talk within the IKK family controls innate immunity

(2011) Kristopher Clark et al.   BIOCHEMICAL JOURNAL

Altered hypothalamic function in diet-induced obesity

(2011) L A Velloso et al.   INTERNATIONAL JOURNAL OF OBESITY

Sixteen years and counting: an update on leptin in energy balance

(2011) Laurent Gautron et al.   JOURNAL OF CLINICAL INVESTIGATION

CNS leptin and insulin action in the control of energy homeostasis

(2010) Bengt F. Belgardt et al.   Annals of the New York Academy of Sciences

Outstanding Scientific Achievement Award Lecture 2010: Deconstructing Leptin: From Signals to Circuits

(2010) M. G. Myers   DIABETES

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

(2010) Rita Moreno et al.   NUCLEIC ACIDS RESEARCH

IKKε modulates RSV-induced NF-κB-dependent gene transcription

(2010) Xiaoyong Bao et al.   VIROLOGY

The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling

(2009) Gregory J. Morton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice

(2009) Patricia O. Prada et al.   DIABETES

Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

(2009) Hui Geng et al.   EMBO REPORTS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism

The IKK-related kinases: from innate immunity to oncogenesis

(2008) Jean-François Clément et al.   CELL RESEARCH

Monitoring FoxO1 Localization in Chemically Identified Neurons

(2008) M. Fukuda et al.   JOURNAL OF NEUROSCIENCE