Review
Biochemistry & Molecular Biology
Sushma Subedi, Santanu Sasidharan, Niharika Nag, Prakash Saudagar, Timir Tripathi
Summary: Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are caused by misfolded protein aggregates, leading to inclusion bodies and plaques. Studies suggest that targeting common epitopes of interacting amyloid proteins could be a more effective therapeutic option. Understanding the molecular details of amyloid cross-seeding could provide insights for developing anti-amyloid therapeutics.
Article
Biophysics
Victoria T. Reichelderfer, Andres F. Chaparro Sosa, Joel L. Kaar, Daniel K. Schwartz
Summary: The interactions between lipid bilayers and insulin can either stabilize or destabilize the protein, preventing or exacerbating the formation of amyloid fibrils.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Zeyaul Islam, Mohamed H. Ali, Anton Popelka, Raghvendra Mall, Ehsan Ullah, Janarthanan Ponraj, Prasanna R. Kolatkar
Summary: Amyloid fibrillation, related to various neurological disorders, was studied by examining lysozyme fibrillation using nano-infrared spectroscopy (nanoIR). The study showed that lysozyme transformed into mainly parallel beta-sheets in its fibrillar structure, and nanoIR can complement other biophysical studies in analyzing the aggregation process for potential therapeutic design against amyloid disorders.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Engineering, Chemical
Wei Liu, Xueting Sun, Xiaoyan Dong, Yan Sun
Summary: The chiral influence of peptide inhibitors on Aβ fibrillogenesis and cytotoxicity was investigated in this study. It was found that the D-enantiomer exhibited stronger inhibition effect on Aβ self-assembly compared to the L-enantiomer, with significant differences in their reaction.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Yuying Liu, Wenhui Zhao, Yunxiang Sun
Summary: The study demonstrates that SWCNT-OH has excellent anti-amyloid properties, inhibiting the fibrillization of beta 2m(21)(-)(31) peptides and destroying pre-formed proto-fibrils.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemical Research Methods
Fatemeh Bardineshin, Seifollah Bahramikia, Reza Khodarahmi, Faranak Hadi
Summary: Mesalazine demonstrates inhibitory and destabilizing effects on human insulin fibrillation, suggesting its therapeutic potential in the treatment of insulin amyloidosis.
JOURNAL OF FLUORESCENCE
(2023)
Article
Biochemistry & Molecular Biology
Reito Nakamura, Ikumi Tomizawa, Atsushi Iwai, Tetsuo Ikeda, Kota Hirayama, Yung Wen Chiu, Takanobu Suzuki, Airi Tarutani, Tatsuo Mano, Atsushi Iwata, Tatsushi Toda, Youhei Sohma, Motomu Kanai, Yukiko Hori, Taisuke Tomita
Summary: Aggregation of alpha-synuclein into amyloid is a pathological hallmark of neurodegenerative disorders, and inhibiting this aggregation can be a potential therapeutic strategy. This study demonstrates that photo-oxygenation using a photocatalyst successfully inhibits alpha-synuclein aggregation by reducing its seeding ability. The oxidation of histidine residue in alpha-synuclein is found to be responsible for this inhibitory effect.
Article
Cell Biology
Abigail K. Elias, Mark R. Wilson, John A. Carver, Ian F. Musgrave
Summary: Clusterin plays an important role in preventing the formation of SEVI amyloid fibrils, dissociating them, and mitigating their enhancement of HIV infection in semen.
Article
Biochemistry & Molecular Biology
Syed Mohammad Zakariya, Masihuz Zaman, Faisal Nabi, Syed Moasfar Ali, Ishrat Jahan, Shahid M. Nayeem, Rizwan Hasan Khan
Summary: This study elaborated the inhibitory effect of Sunset Yellow dye on the fibril formation of Human Serum Albumin. Various techniques were used to investigate the inhibitory mechanism, and the results confirmed its effectiveness. This finding provides a potential new approach for preventing amyloidogenic diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemical Research Methods
R. Prabakaran, Puneet Rawat, Sandeep Kumar, M. Michael Gromiha
Summary: This review provides a rigorous performance analysis of nine prediction tools for protein and peptide aggregation, revealing the robustness of current prediction tools and their potential for improvement. Insights gained from this work offer critical guidance to the scientific community on the advantages and limitations of different aggregation prediction methods.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Biochemistry & Molecular Biology
Anna Sulatskaya, Anastasiia O. Kosolapova, Alexander G. Bobylev, Mikhail Belousov, Kirill S. Antonets, Maksim Sulatsky, Irina M. Kuznetsova, Konstantin K. Turoverov, Olesya Stepanenko, Anton A. Nizhnikov
Summary: Both amyloids and beta-barrel proteins have beta-sheet-rich structures, with the latter being able to form functional amyloids in vivo. These beta-barrel amyloid proteins can interact with each other and form toxic oligomers, potentially contributing to the development of amyloidoses. Rapidly growing discoveries suggest that the number and diversity of functions of amyloid-forming beta-barrel proteins are significantly greater than currently understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Bikash R. Sahoo, James C. A. Bardwell
Summary: Amyloid formation is a misfolding process associated with age-related diseases. Understanding the cellular factors that affect this process is crucial for controlling it. SERF proteins play a role in accelerating polyglutamine amyloid formation and nucleation. The biological functions of SERF proteins, particularly their nucleic acid-binding function and its relationship with their ability to accelerate amyloid formation, are still unclear.
Article
Immunology
Kyle M. Reid, Guy C. Brown
Summary: This study found that microglia release LRPAP1 when inflammatory activated or ER stressed. LRPAP1 can inhibit microglial phagocytosis, uptake of A beta, and A beta aggregation. Thus, the release of LRPAP1 may regulate microglial functions and A beta pathology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Michael C. Wilson, Qin Lu, Kaitlin R. Nachtrieb, Jackson S. Fuller, Chloe M. Skogg, Elizabeth A. Yates, Matthew D. Thum, Christopher R. So
Summary: This study demonstrates the chemical aggregation of common hydrophilic proteins into an aqueous adhesive similar to natural adhesives. By using multiple chemical denaturants, rapid gelation and further curing in artificial seawater can be achieved. The adhesive strengths of this waterborne adhesive are comparable to bioinspired adhesives that use organic solvents and hydrophobic components. This approach enables the deployment of a bioinspired adhesive at practical scales in marine environments, with sustainable production and low-cost materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Meghna Dabur, Joana A. Loureiro, Maria Carmo Pereira
Summary: Amyloidosis is a disease caused by improperly folded proteins accumulating in tissues and damaging organs. It has a significant impact on global health, but there are currently no effective treatments available. However, recent research has shown the potential of fluorine-modified therapeutic molecules and nanoparticles in regulating amyloidogenic proteins.
Review
Biochemistry & Molecular Biology
Gulam Rabbani, Ejaz Ahmad, Abrar Ahmad, Rizwan Hasan Khan
Summary: Microbial lipases are excellent biocatalysts that can catalyze various reactions in both aqueous and non-aqueous media. This review focuses on microbial lipases from different sources (psychrophiles, mesophiles, and thermophiles), highlighting the structural diversity in temperature adaptation and industrial applications. Understanding the molecular mechanisms of temperature adaptation in lipases is of great interest, as extremophilic lipases are widely used in biotransformation reactions with higher yields and unique products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Education, Scientific Disciplines
Mohammad Rehan Ajmal, Fahad Mohammad Almutairi, Arif Hussain, Mohammad Fahad Ullah, M. Ayaz Ahmad, Ali Saber Abdelhameed, Hussain Arif
Summary: In this study, the interaction between human DHX8 and four test compounds (Etoposide, Netropsin, Nogalamycin, and Novobiocin) was investigated using molecular docking and fluorescence emission spectra techniques. The results showed a strong binding preference of DHX8 for Novobiocin, and a concentration of 2.5 μM of Novobiocin was found to effectively inhibit the activity of DHX8. These findings provide valuable insights into the inhibition of DHX8 and contribute to the development of Novobiocin as a therapeutic molecule against targeted diseases.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Navodit Kumar Singh, Jaya Baranwal, Siddhartha Pati, Brajesh Barse, Rizwan Hasan Khan, Amit Kumar
Summary: The burning of plastic waste leads to air pollution due to the release of toxic gases. Developing biodegradable polymers with similar characteristics to those derived from petroleum is crucial. To mitigate the impact of these issues, we need to focus on alternative sources that can biodegrade naturally.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Gad Elsayed Mohamed Salem, Shaimaa M. Azzam, Mona A. F. Nasser, Tamer El Malah, Hanan M. Abd El-Latief, Rizwan Hasan Khan, Suchana Chavanich, Hend Mohamed Anwar
Summary: This study focuses on evaluating the anti-inflammatory and antioxidant effects of Bacterial Protease (BP) and 4,4'-(2,5-dimethoxy-1,4-phenylene) bis (1-(3-ethoxy phenyl)-1H-1,2,3-triazole) (DPET) in treating early-stage liver fibrosis induced by thioacetamide (TAA). The results showed that treatment with BP can improve the severe effects of TAA on the liver, restore tissue architecture, and have the potential to alleviate liver fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Syed Moasfar Ali, Faisal Nabi, Mohammad Furkan, Malik Hisamuddin, Sadia Malik, Syed Mohammad Zakariya, Irum Rizvi, Vladimir N. Uversky, Rizwan H. Khan
Summary: Protein misfolding and amyloid fibril formation are linked to various conformational diseases. Luteolin, a natural flavonoid, has been found to inhibit the aggregation of human insulin, indicating its potential therapeutic role in neuroinflammation. Molecular simulation and spectroscopic techniques confirmed the inhibitory effect of luteolin on the aggregation process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Syed Moasfar Ali, Faisal Nabi, Malik Hisamuddin, Irum Rizvi, Azeem Ahmad, Md Nadir Hassan, Pradipta Paul, Ali Chaari, Rizwan H. Khan
Summary: Protein misfolding in amyloidosis is linked to various pathophysiological conditions. Inhibition of toxic aggregates or disaggregation of preformed fibrils is an important strategy in preventing these diseases. Natural compounds, such as luteolin, have been shown to prevent amyloid fibril formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Suliman Khan, William C. Cho, Arif Hussain, Sadaf Azimi, Mohammad Mahdi Nejadi Babadaei, Samir Haj Bloukh, Zehra Edis, Mesha Saeed, Timo L. M. ten Hagen, Hosein Ahmadi, Mahsa Ale-Ebrahim, Laila Abdulmohsen Jaragh-Alhadad, Rizwan Hasan Khan, Mojtaba Falahati, Xiaoju Zhang, Qian Bai
Summary: In biological systems, nanoparticles (NPs) have complex interactions with proteins, including the formation of protein corona and structural changes. These interactions depend on both the physicochemical properties of NPs and the stability of protein molecules. This review discusses the direct bio-chemical and biophysical interactions between NPs and blood proteins, specifically transferrin. The study explores the effects of NP properties on protein structure, transferrin stability, and its applications in drug delivery systems for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mohd Aamir Qureshi, Mohd Amir, Rizwan Hasan Khan, Javed Musarrat, Saleem Javed
Summary: This study investigates the binding efficiency of Aflatoxin B-1 (AFB(1)) with Human Serum Albumin (HSA) using multi-spectroscopic approaches. The results reveal that AFB(1) can bind to HSA and alter its structure and conformation, providing insight into the toxic effect of this mycotoxin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Correction
Biochemistry & Molecular Biology
Moyad Shahwan, Nageeb Hassan, Akram Ashames, Mohammed Alrouji, Fahad Alhumaydhi, Waleed Al Abdulmonem, Abdullatif Bin Muhsinah, Mohammad Furkan, Rizwan Hasan Khan, Anas Shamsi, Akhtar Atiya
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Nida Naseem, Md Fahim Ahmad, Sadia Malik, Rizwan Hasan Khan, Waseem A. Siddiqui
Summary: This study demonstrates the anti-fibrillatory effect of esculin on human insulin fibrillation and validates its ability to alleviate diabetic neuropathy through behavioral tests, biochemical parameter assessment, and histopathology analysis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Nabeela Majid, Rizwan Hasan Khan
Summary: Proteins are vital for cellular functions, but variations in environmental conditions can disrupt their stability and lead to aggregation. Under normal conditions, aggregated proteins are removed by a quality control system, but diseased conditions or impaired systems can result in toxicity. Misfolding and aggregation of certain proteins are linked to diseases like Alzheimer's and Parkinson's. Current treatments are symptomatic and lack the ability to target the cause of these diseases. Therefore, more research is needed to develop drugs that address the root cause. This review provides valuable knowledge and strategies for researchers in neuroscience.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Sadia Malik, Faisal Nabi, Mohammad Khursheed Siddiqi, Aiman Masroor, Malik Hisamuddin, Tajalli Ilm Chandel, Nabeela Majid, Rizwan Hasan Khan
Summary: This study confirms the inhibitory effect of lipophilic FAEE on insulin fibrillation, which can cross the blood brain barrier and stabilize the monomeric state of insulin, thereby preventing the extension of fibrillation.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Biomaterials
Nabeela Majid, Mohammad Khursheed Siddiqi, Md. Nadir Hassan, Sadia Malik, Seema Khan, Rizwan Hasan Khan
Summary: The aggregation of soluble proteins into insoluble fibrils is a key factor in the development of amyloid-associated disorders. In this study, the anti-diabetic drug chlorpropamide was found to effectively inhibit the aggregation of human lysozyme in vitro, reducing its cytotoxicity. Additionally, chlorpropamide was found to not only inhibit fibrillation but also stabilize the protein in its native state.
BIOMATERIALS ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Nageeb Hassan, Akram Ashames, Mohammed Alrouji, Fahad Alhumaydhi, Waleed Al Abdulmonem, Abdullatif Bin Muhsinah, Mohammad Furkan, Rizwan Hasan Khan, Anas Shamsi, Akhtar Atiya
Summary: This study aimed to find a potential SphK1 inhibitor through virtual screening and identified a compound with high potential. The stability of the compound and its binding with SphK1 were evaluated through various molecular dynamics and analysis methods. The results provide a platform for the discovery and development of new anticancer therapeutics targeting SphK1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Anas Shamsi, Mohammad Furkan, Rizwan Hasan Khan, Mohd Shahnawaz Khan, Moyad Shahwan, Dharmendra Kumar Yadav
Summary: This study deciphers the binding mechanism between rutin and human transferrin, and suggests that rutin can be used for the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)