A Law of Redundancy Compounds the Problem of Cancer and Precision Medicine

Breast cancer heterogeneity and its implication in personalized precision therapy

(2023) Liantao Guo et al.   Experimental Hematology & Oncology

Challenges and Opportunities for Clinical Cytogenetics in the 21st Century

(2023) Eric Heng et al.   Genes

Precision and personalized medicine: What their current definition says and silences about the model of health they promote. Implication for the development of personalized health

(2023) Cyrille Delpierre et al.   Frontiers in Sociology

The Origin of Life: What Is the Question?

(2022) Christophe Malaterre et al.   ASTROBIOLOGY

Breast Cancer Genomics: Primary and Most Common Metastases

(2022) Caroline Bennett et al.   Cancers

Precision medicine in 2030—seven ways to transform healthcare

(2021) Joshua C. Denny et al.   CELL

The Illusions of the Modern Synthesis

(2021) Denis Noble   Biosemiotics

Decoding ‘Unnecessary Complexity’: A Law of Complexity and a Concept of Hidden Variation Behind “Missing Heritability” in Precision Medicine

(2021) Rama S. Singh   JOURNAL OF MOLECULAR EVOLUTION

Karyotype coding: The creation and maintenance of system information for complexity and biodiversity

(2021) Julie Heng et al.   BIOSYSTEMS

Mutational load and the functional fraction of the human genome

(2020) Benjamin Galeota-Sprung et al.   Genome Biology and Evolution

How to link genomics to physiology through epigenomics

(2020) Denis Noble et al.   Epigenomics

Over a century of cancer research: Inconvenient truths and promising leads

(2020) Carlos Sonnenschein et al.   PLOS BIOLOGY

Genes and genomes and unnecessary complexity in precision medicine

(2020) Rama S. Singh et al.   npj Genomic Medicine

Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression

(2020) Melissa Emamalipour et al.   Frontiers in Cell and Developmental Biology

Systems Biology Approaches to Understanding the Human Immune System

(2020) Bhavjinder K. Dhillon et al.   Frontiers in Immunology

Strategies of the War on Cancer: To Kill or to Neutralize?

(2019) Anatoly V. Lichtenstein   Frontiers in Oncology

Translating cancer genomics into precision medicine with artificial intelligence: applications, challenges and future perspectives

(2019) Jia Xu et al.   HUMAN GENETICS

Developmental Systems Drift and the Drivers of Sex Chromosome Evolution

(2019) Caroline M S Cauret et al.   MOLECULAR BIOLOGY AND EVOLUTION

Heterophylly: Phenotypic Plasticity of Leaf Shape in Aquatic and Amphibious Plants

(2019) Gaojie Li et al.   Plants-Basel

Nothing in cancer makes sense except…

(2018) Mel Greaves   BMC BIOLOGY

A Physicist’s Quest in Biology: Max Delbrück and “Complementarity”

(2017) Bernard S. Strauss   GENETICS

An Upper Limit on the Functional Fraction of the Human Genome

(2017) Dan Graur   Genome Biology and Evolution

Differences between germline and somatic mutation rates in humans and mice

(2017) Brandon Milholland et al.   Nature Communications

A Physicist’s Quest in Biology: Max Delbrück and “Complementarity”

(2017) Bernard S. Strauss   GENETICS

Mutation and Human Exceptionalism: Our Future Genetic Load

(2016) M. Lynch   GENETICS

The Expanding Landscape of Moonlighting Proteins in Yeasts

(2016) Carlos Gancedo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The role of p53 in cancer drug resistance and targeted chemotherapy

(2016) Karin Hientz et al.   Oncotarget

Developmental Drift and the Role of Wnt Signaling in Aging

(2016) Jan Gruber et al.   Cancers

Somatic mutation in single human neurons tracks developmental and transcriptional history

(2015) M. A. Lodato et al.   SCIENCE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Theoretical models of the influence of genomic architecture on the dynamics of speciation

(2014) Samuel M. Flaxman et al.   MOLECULAR ECOLOGY

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

Rethinking the war on cancer

(2013) Douglas Hanahan   LANCET

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Evolutionary layering and the limits to cellular perfection

(2012) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenes in Cell Survival and Cell Death

(2012) J. Shortt et al.   Cold Spring Harbor Perspectives in Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

What fraction of the human genome is functional?

(2011) C. P. Ponting et al.   GENOME RESEARCH

Defining Life

(2010) Steven A. Benner   ASTROBIOLOGY

The molecular pathology of breast cancer progression

(2010) Alessandro Bombonati et al.   JOURNAL OF PATHOLOGY

Rate, molecular spectrum, and consequences of human mutation

(2010) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of the mutation rate

(2010) Michael Lynch   TRENDS IN GENETICS

Metastasis mechanisms

(2009) Thomas R. Geiger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Evolution of genome architecture

(2008) Eugene V. Koonin   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY