Challenges and Opportunities for Clinical Cytogenetics in the 21st Century

Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

(2023) Ivana Ban et al.   BIOPHYSICAL JOURNAL

Loss of epigenetic information as a cause of mammalian aging

(2023) Jae-Hyun Yang et al.   CELL

Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells

(2023) Xiaoran Li et al.   ONCOGENE

Frequent copy number variants in a cohort of Mexican-Mestizo individuals

(2023) Silvia Sánchez et al.   Molecular Cytogenetics

Physiological mechanisms of stress-induced evolution

(2022) Elizabeth A. Mojica et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

(2022) Andrew R Lynch et al.   eLife

Distinct and Common Features of Numerical and Structural Chromosomal Instability across Different Cancer Types

(2022) Xiaoxiao Zhang et al.   Cancers

GraphChrom: A Novel Graph-Based Framework for Cancer Classification Using Chromosomal Rearrangement Endpoints

(2022) Golrokh Mirzaei   Cancers

CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy

(2022) Mario Amendola et al.   Stem Cells Translational Medicine

Editorial: Somatic genomic mosaicism & human disease

(2022) Ivan Y. Iourov et al.   Frontiers in Genetics

Chromosomal Heteromorphisms and Cancer Susceptibility Revisited

(2022) Thomas Liehr   Cells

Human genetic diversity alters off-target outcomes of therapeutic gene editing

(2022) Samuele Cancellieri et al.   NATURE GENETICS

Spatial biology of cancer evolution

(2022) Zaira Seferbekova et al.   NATURE REVIEWS GENETICS

Two-phased evolution: Genome chaos-mediated information creation and maintenance

(2021) Julie Heng et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

About classical molecular genetics, cytogenetic and molecular cytogenetic data not considered by Genome Reference Consortium and thus not included in genome browsers like UCSC, Ensembl or NCBI

(2021) Thomas Liehr   Molecular Cytogenetics

Telomere Architecture Correlates with Aggressiveness in Multiple Myeloma

(2021) Aline Rangel-Pozzo et al.   Cancers

Chromosome Instability, Aging and Brain Diseases

(2021) Ivan Y. Iourov et al.   Cells

The Importance of Henry H. Heng's Genome Architecture Theory

(2021) Rafe Furst   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Therapy Induced Genome Chaos: A Novel Mechanism of Rapid Cancer Drug Resistance

(2021) Jing Christine Ye et al.   Frontiers in Cell and Developmental Biology

Karyotype coding: The creation and maintenance of system information for complexity and biodiversity

(2021) Julie Heng et al.   BIOSYSTEMS

Large‐scale topological disruption of chromosome territories 9 and 22 is associated with nonresponse to treatment in CML

(2021) Eunice Fabian‐Morales et al.   INTERNATIONAL JOURNAL OF CANCER

Chromoanagenesis: a piece of the macroevolution scenario

(2020) Franck Pellestor et al.   Molecular Cytogenetics

Origins and Consequences of Chromosomal Instability: From Cellular Adaptation to Genome Chaos-Mediated System Survival

(2020) Christine J. Ye et al.   Genes

Genome chaos: Creating new genomic information essential for cancer macroevolution

(2020) Julie Heng et al.   SEMINARS IN CANCER BIOLOGY

Nonclonal Chromosome Aberrations and Genome Chaos in Somatic and Germ Cells from Patients and Survivors of Hodgkin Lymphoma

(2019) Sara Frias et al.   Genes

From Human Cytogenetics to Human Chromosomics

(2019) Thomas Liehr   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Micronuclei and Genome Chaos: Changing the System Inheritance

(2019) Christine J. Ye et al.   Genes

Nonclonal chromosomal alterations and poor survival in cytopenic patients without hematological malignancies

(2019) Osamu Imataki et al.   Molecular Cytogenetics

What Is Karyotype Coding and Why Is Genomic Topology Important for Cancer and Evolution?

(2019) Christine J. Ye et al.   Frontiers in Genetics

The variome concept: focus on CNVariome

(2019) Ivan Y. Iourov et al.   Molecular Cytogenetics

A Postgenomic Perspective on Molecular Cytogenetics

(2018) Henry H. Heng et al.   CURRENT GENOMICS

Detecting Chromosome Condensation Defects in Gulf War Illness Patients

(2018) Guo Liu et al.   CURRENT GENOMICS

Structural variation in the 3D genome

(2018) Malte Spielmann et al.   NATURE REVIEWS GENETICS

The Dualistic Origin of Human Tumors

(2018) Jinsong Liu   SEMINARS IN CANCER BIOLOGY

Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems

(2018) Christine J. Ye et al.   Molecular Cytogenetics

Genomic chaos in peripheral blood lymphocytes of Hodgkin's lymphoma patients one year after ABVD chemotherapy/radiotherapy

(2018) Sandra Ramos et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Nonclonal Chromosomal Aberrations in Childhood Leukemia Survivors

(2018) Tong Foh Chin et al.   Fetal and Pediatric Pathology

Transient and stable vector transfection: Pitfalls, off-target effects, artifacts

(2017) Aleksei A. Stepanenko et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Tracking the Evolution of Non–Small-Cell Lung Cancer

(2017) Mariam Jamal-Hanjani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

(2017) Teresa Davoli et al.   SCIENCE

New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response

(2017) Nelson Rangel et al.   Genes

The Role of Chromosomal Instability in Cancer and Therapeutic Responses

(2017) Natalia Vargas-Rondón et al.   Cancers

Revealing hidden complexities of genomic rearrangements generated with Cas9

(2017) Katharina Boroviak et al.   Scientific Reports

Chromosome abnormalities at onset of complete remission are associated with worse outcome in patients with acute myeloid leukemia and an abnormal karyotype at diagnosis: CALGB 8461 (Alliance)

(2016) C. Niederwieser et al.   HAEMATOLOGICA

High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing

(2016) Jeffrey R. Moffitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why it is crucial to analyze non clonal chromosome aberrations or NCCAs?

(2016) Henry H. Q. Heng et al.   Molecular Cytogenetics

Chromosome abnormalities at onset of complete remission are associated with worse outcome in patients with acute myeloid leukemia and an abnormal karyotype at diagnosis: CALGB 8461 (Alliance)

(2016) C. Niederwieser et al.   HAEMATOLOGICA

Linking genomic reorganization to tumor initiation via the giant cell cycle

(2016) N Niu et al.   Oncogenesis

Genome chaos: Survival strategy during crisis

(2014) Guo Liu et al.   CELL CYCLE

Stress, genomic adaptation, and the evolutionary trade-off

(2014) Steven D. Horne et al.   Frontiers in Genetics

Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution

(2013) Henry H. Heng et al.   CANCER AND METASTASIS REVIEWS

Punctuated Evolution of Prostate Cancer Genomes

(2013) Sylvan C. Baca et al.   CELL

Karyotype Heterogeneity and Unclassified Chromosomal Abnormalities

(2013) H.H.Q. Heng et al.   CYTOGENETIC AND GENOME RESEARCH

Trisomy 21 Mosaicism: We May All Have a Touch of Down Syndrome

(2013) M.A. Hultén et al.   CYTOGENETIC AND GENOME RESEARCH

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology

(2013) Steven D. Horne et al.   Systems Biology in Reproductive Medicine

Single Cell Genomics of the Brain: Focus on Neuronal Diversity and Neuropsychiatric Diseases

(2012) Ivan Y Iourov et al.   CURRENT GENOMICS

Formation of solid tumors by a single multinucleated cancer cell

(2011) Zhang Weihua et al.   CANCER

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Decoding the genome beyond sequencing: The new phase of genomic research

(2011) Henry H.Q. Heng et al.   GENOMICS

Diverse system stresses: common mechanisms of chromosome fragmentation

(2011) J B Stevens et al.   Cell Death & Disease

SEX REDUCES GENETIC VARIATION: A MULTIDISCIPLINARY REVIEW

(2010) Root Gorelick et al.   EVOLUTION

Higher-order Genome Organization in Human Disease

(2010) T. Misteli   Cold Spring Harbor Perspectives in Biology

Chromosome Territories

(2010) T. Cremer et al.   Cold Spring Harbor Perspectives in Biology

The genome-centric concept: resynthesis of evolutionary theory

(2009) Henry H. Q. Heng   BIOESSAYS

The Evolution of Meiosis From Mitosis

(2009) A. S. Wilkins et al.   GENETICS

Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer

(2009) Christine J. Ye et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of nuclear organization in cancer

(2009) Elliott Lever et al.   JOURNAL OF PATHOLOGY

The Conflict Between Complex Systems and Reductionism

(2008) Henry H. Q. Heng   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chromosome heteromorphisms: an impact on infertility

(2008) Feride Iffet Sahin et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Chromosomal mosaicism goes global

(2008) Ivan Y Iourov et al.   Molecular Cytogenetics