Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1

Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway

(2022) Qian Li et al.   International Journal of Biological Sciences

Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases

(2022) Min-Ji Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

(2022) Ricardo Amorim et al.   Redox Biology

Design and characterization of a heterobifunctional degrader of KEAP1

(2022) Hao Chen et al.   Redox Biology

Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress

(2021) Mei-hui Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Steatotic hepatocytes release mature VLDL via methionine and tyrosine metabolism in a Keap1‐Nrf2 dependent manner

(2021) Akitoshi Sano et al.   HEPATOLOGY

Targeted protein degraders crowd into the clinic

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

(2021) Jieli Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and synthesis of novel mitochondria-targeted CDDO derivatives as potential anti-cancer agents

(2021) Wei Ju et al.   BIOORGANIC CHEMISTRY

Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

(2021) Juntao Yuan et al.   Redox Biology

Astaxanthin attenuates hepatic damages and mitochondrial dysfunction in nonalcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway

(2020) Liwei Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

(2020) Habib Yaribeygi et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo

(2020) Mingming Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation

(2020) Hee-Seon Park et al.   Autophagy

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation

(2019) Zechuan Zhang et al.   JOURNAL OF HEPATOLOGY

Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease

(2019) Ze Chen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis

(2018) Xiaoyu Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Time to step-up the fight against NAFLD

(2018) Xiao-Jing Zhang et al.   HEPATOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state

(2018) Hongming Su et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice

(2018) Rui Li et al.   International Journal of Biological Sciences

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling

(2018) Albert van der Vliet et al.   MOLECULAR ASPECTS OF MEDICINE

Nrf2 activator for the treatment of kidney diseases

(2018) Kengo Yamawaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Redox-Mediated Regulatory Mechanisms of Endoplasmic Reticulum Homeostasis

(2018) Ryo Ushioda et al.   Cold Spring Harbor Perspectives in Biology

Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

(2017) Meng Li et al.   GUT

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

(2017) Ian Churcher   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Stress and Inflammation in Cardiovascular Disease

(2017) Noemí García et al.   Oxidative Medicine and Cellular Longevity

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

(2016) Da Hyun Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

Role of NADPH oxidases in the redox biology of liver fibrosis

(2015) Eva Crosas-Molist et al.   Redox Biology

Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment

(2014) Yan-Yang Wang et al.   Molecular Cancer

Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

(2014) Anne Cleasby et al.   PLoS One

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE